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All Journal CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Insan Farmasi Indonesia Indonesian Journal of Chemical Science
Efriyana Oksal
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Physics Social Sciences

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FORMULASI DAN UJI EFEKTIVITAS SEDIAAN GEL EKSTRAK DAUN BAJAKAH KALALAWIT (Uncaria gambir Roxb.) TERHADAP PROSES PENYEMBUHAN LUKA BAKAR PADA MENCIT PUTIH Ayuchecaria, Noverda; Yohanes Edy Gunawan; Efriyana Oksal; Shesanthi Citrariana
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1635

Abstract

Burns are tissue loss caused by contact with heat sources. Burns will not only cause skin damage, but also affect the entire body system. Bajakah kalalawit contains polyphenolic compounds. This research aims to design a gel preparation formulation that is effective in the healing process of burn wounds in white mice. The preparation was also tested for its physicochemical characteristics including organoleptic test, homogeneity test, pH test, spreadability and stickiness test and irritation test. The results showed that all formulas were homogeneous and no organoleptic changes occurred after 14 days. The pH range of Bajakah gel is 6.16 – 7.46 which meets the skin's pH requirements. The diameter range of spreading power is between 5-7 cm. The adhesion power of formulas 2 and 3 meets the requirements (<4 seconds). The four formulas did not show irritation in the irritation test. The conclusion of this research is that Bajakah kalalawite extract gel with the composition of Formulas 2 and 3 meets the requirements for physical quality characteristic tests including organoleptic, homogeneity, pH, spreadability, adhesive power and irritation test. The diameter of the burn wound showed that there was a significant difference in treatment compared to the negative control group (p<5%).
Teknik Pengelolaan Sanitasi Lingkungan untuk Meningkatkan Kesadaran Kesehatan Masyarakat Pereiz, Zimon Pereiz; Chuchita; Efriyana Oksal; Joy Angel Aria Suma; Febrianto Afli; Waluyo Nuswantoro
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2024): Desember
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v7i2.2525

Abstract

Abstrak. Lingkungan hidup yang baik dan sehat sangat penting untuk kelangsungan hidup warga masyarakat. Sanitasi merupakan salah satu upaya untuk menjaga lingkungan dan kesehatan masyarakat dengan mengawasi faktor lingkungan hidup. Kegiatan sosialisasi teknik pengelolaan sanitasi lingkungan bagi warga masyarakat di Kelurahan Habaring Hurung telah dilaksanakan dengan baik. Kegiatan ini dilakukan melalui kerjasama dengan mitra yaitu kelompok warga masyarakat, kepala kelurahan dan staf Kelurahan Habaring Hurung, Kecamatan Bukit Batu, Kota Palangka Raya, Kalimantan Tengah. Kegiatan ini berlangsung dalam empat tahapan kegiatan, yaitu tahap survey lokasi, pengumpulan materi kegiatan, pelaksanaan kegiatan pengelolaan sanitasi lingkungan dan diakhiri dengan indikator keberhasilan. Berdasarkan hasil kegiatan, dapat disimpulkan bahwa kegiatan pengabdian masyarakat ini dapat menambah wawasan dan kemampuan tentang bagaimana melakukan teknik pengelolaan sanitasi lingkungan. Hal tersebut dapat kita lihat dari hasil kuisioner melalui pre-test dan post-test yang telah diisi oleh peserta kegiatan, dimana rata-rata peserta sebelum mengikuti kegiatan ini menjawab kurang mengetahui tentang teknik pengelolaan sanitasi lingkungan. Namun melalui informasi atau konten materi yang telah disampaikan, masyarakat menjadi mengerti dan memahaminya. Abstract. A good and healthy environment is very important for the survival of the community. Sanitation is one of the efforts to maintain the environment and public health by monitoring environmental factors. The socialization activity of environmental sanitation management techniques for residents in Habaring Hurung Village has been carried out well. This activity was carried out through collaboration with partners, namely community groups, village heads and staff of Habaring Hurung Village, Bukit Batu District, Palangka Raya City, Central Kalimantan. This activity took place in four stages of activity, namely the location survey stage, collection of activity materials, implementation of environmental sanitation management activities and ending with success indicators. Based on the results of the activity, it can be concluded that this community service activity can increase insight and ability on how to carry out environmental sanitation management techniques. This can be seen from the results of the questionnaire through the pre-test and post-test that have been filled out by the participants of the activity, where the average participant before participating in this activity answered that they did not know much about environmental sanitation management techniques. However, through the information or content of the material that has been delivered, the community understands and comprehends it.
Interaction Study of BCN OH ( Bicyclononyn ) and Pertuzumab in the Development of ADC ( Antibody Drug Conjugation ) Through Virtual Screening Alwia, Nisa; Aden Dhana Rizkita1; Tris Ella Julita Gulo; Nisa Sri Wahyuni; Risma Eka Putri Selay; Ayu Andini Rizki Lestari Rohman; Efriyana Oksal; Kumam Pinky Chanu; Asaduzzaman; Taufik Muhammad Faqih5
Indonesian Journal of Chemical Science Vol. 13 No. 2 (2024): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ADC (Antibody Drug Conjugation) is a complex molecule consisting of antibodies designed as a targeted therapy to treat disease, or a biologically active cytotoxic drug. Docking simulations of the pertuzumab antibody with the BCN OH ligand were carried out to see the interactions and stable conjugates between the antibody and the ligand as a form of ADC development using three software, consisting of Discovery Studio, pymol and pyrex. The pymol application is used for the preparation of pertuzumab, namely removing residues and water and is used to combine the ligand with the antibody, while the use of Pyrex Autodocx Vina is to determine the conformation of the ligand in binding with the macromolecule. Discovery studio is used to realize the bond between the linker and antibody and see the interactions that occur. This research aims to determine the interaction of pertuzumab with BCN OH as a starting point for selecting a suitable ligand for the ADC product so that later the ADC will be more stable until the target of the simulations carried out is obtained by the results of interactions that occur between pertuzumab and the BCN OH molecule. After being realized in two dimensions, it can be seen that there are amino acid compounds that bind to BCN OH on side B:103, there is lysine, side B:40 proline, side B:38 Arginine, side B:85 Threonine, and on side B:415 there is Air molecules. In the docking process, the presence of lysine bonds is an important factor in looking at the interaction of compounds with their macromolecules, considering that lysine is one of the residues that will bind to the functional groups on the linker to produce ADC products.
Edukasi Kesehatan dan Pelatihan Pengolahan Teh Celup Bawang Dayak sebagai Upaya Peningkatan Kesehatan Herbal Berbasis Lokal Ahmad Irawan; Pereiz, Zimon; Hendrik Segah; Chuchita; Efriyana Oksal; Aji Pamungkas
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 2 (2025): Desember
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v8i2.3202

Abstract

Kegiatan pengabdian kepada masyarakat ini dilaksanakan di Kelurahan Habaring Hurung, Kecamatan Bukit Batu, Kota Palangka Raya, dengan fokus pada peningkatan pengetahuan serta keterampilan masyarakat dalam memanfaatkan bawang dayak (Eleutherine palmifolia) sebagai teh celup herbal untuk membantu menurunkan kadar gula darah. Pelaksanaan program menggunakan pendekatan partisipatif yang mencakup sosialisasi, diskusi interaktif, demonstrasi, praktik langsung, serta evaluasi melalui pre-test dan post-test. Sebanyak 50 orang berpartisipasi, terdiri atas ibu rumah tangga, kader PKK, tokoh masyarakat, remaja, hingga warga lanjut usia yang berisiko diabetes. Hasil kegiatan memperlihatkan peningkatan yang sangat signifikan: pemahaman masyarakat meningkat dari 11,2% pada pre-test menjadi 97,2% pada post-test. Selain itu, keterampilan peserta dalam mengolah bawang dayak menjadi teh celup higienis juga semakin baik, sehingga mereka mampu menerapkan teknik pengolahan dengan benar. Dampak program ini tidak hanya meningkatkan kesadaran masyarakat terhadap pentingnya pemanfaatan tanaman obat lokal, tetapi juga membuka peluang usaha mikro berbasis herbal yang bernilai ekonomi. Dengan demikian, kegiatan ini dapat dijadikan contoh model pemberdayaan masyarakat yang berkelanjutan, yang mendukung ketahanan kesehatan sekaligus perekonomian rumah tangga berbasis kearifan lokal.
Co-Authors Aden Dhana Rizkita1 Ahmad Irawan Aji Pamungkas Alwia, Nisa Asaduzzaman Ayu Andini Rizki Lestari Rohman Ayuchecaria, Noverda Chuchita Citrariana, Shesanthi Febrianto Afli Hendrik Segah Joy Angel Aria Suma Kumam Pinky Chanu Risma Eka Putri Selay Taufik Muhammad Faqih5 Tris Ella Julita Gulo Wahyuni, Nisa Sri Waluyo Nuswantoro Yohanes Edy Gunawan Zimon Pereiz