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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Praeparandi : Jurnal Farmasi dan Sains
Sari, Rizka Noviana
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

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UJI AKTIVITAS ANTIBAKTERI TABLET HISAP KOMBINASI EKSTRAK DAUN SIRIH HIJAU (Piper betle L.) DAN RIMPANG JAHE (Zingiber officinale) TERHADAP BAKTERI Staphylococcus aureus Haryati, Ety; Sari, Rizka Noviana; Nurpatmawati, Nurpatmawati; Zakiyah, Fitri
Praeparandi : Jurnal Farmasi dan Sains Vol 6 No 2 (2023): Praeparandi : Jurnal Farmasi dan Sains
Publisher : Praeparandi : Jurnal Farmasi dan Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.445 KB) | DOI: 10.58365/ojs.v6i2.205

Abstract

Tanaman sirih hijau (Piper betle L.) dan rimpang jahe (Zingiber officinale) memiliki kandungan tanin, saponin dan flavonoid yang berfungsi sebagai antibakteri. Mempertimbangkan kemudahan dalam pemakaian maka ekstrak daun sirih hijau (Piper betle L.) dan jahe (Zingiber officinale) dibuat sediaan tablet hisap yang lebih praktis. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri tablet hisap kombinasi ekstrak daun sirih hijau (Piper betle L.) dan rimpang jahe (Zingiber officinale) terhadap bakteri Staphylococcus aureus. Metode penelitian ini adalah eksperimental. Tablet hisap dibuat dengan formula X1 perbandingan ekstrak daun sirih hijau dan rimpang jahe 2:2, formula X2 dengan perbandingan 3:1 dan formula X3 dengan perbandingan 1:3. Kontrol positif yang digunakan kloramfenikol 50 μg dan kontrol negatif yang digunakan tablet hisap tanpa ekstrak daun sirih hijau dan rimpang jahe. Aktivitas antibakteri menggunakan metode difusi sumuran dengan mengukur zona bening pada media agar padat. Hasil zona bening dianalisis menggunakan One Way ANOVA dan Post Hoc. Hasil penelitian menunjukkan bahwa zona bening yang dihasilkan untuk masingmasing formula yaitu X1 (10mm), formula X2 (8,09 mm), formula X3 (16,02 mm), kontronegatif (3,22 mm) dan kontrol positif (16,27 mm). Berdasarkan hasil analisis data didapatkan bahwa tablet hisap kombinasi esktrak daun sirih hijau (Piper betleL.) dan rimpang jahe (Zingiber officinale) mempunyai aktivitas antibakteri terhadap bakteri Staphylococcus aureus dengan formula X3 yang memiliki aktivitas antibakteri paling besar dengan nilai sig (0,517 > 0,05).
Optimasi Formula Sediaan Minyak Telon Bayi Tree Tea Oil (Melaleuca alternifolia Cheel) dengan Variasi VCO dan Olive Oil dengan Metode Simplex Lattice Design Adityas, Hanung Puspita; Wulansari, Eka; Sari, Rizka Noviana
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p118-127

Abstract

One of the plants that can be used as a natural medicine is the tea tree plant (Melaleuca alternifolia Cheel) which is generally known as the tea tree. The tea tree plant contains essential oils which are useful as antimicrobial and anti-inflammatory. Another plant that can be used as a natural ingredient is the fennel plant (Foeniculum vulgare Mill) which contains essential oils which are useful as antimicrobials. In order to develop the preparation, a telon oil preparation was formulated. The use of additional ingredients in the formulation of telon oil preparations, namely VCO and Olive Oil as vegetable oils which function as solvents for essential oils, can certainly affect the physical properties of telon oil preparations, so a method is needed to find an optimum formula that meets the good physical properties of the preparation. This research aims to determine the optimum formula composition of telon oil preparations with variations of VCO and Olive Oil using the Simplex Lattice Design method by looking at the results of evaluation tests of the physical properties of telon oil preparations which include organoleptic tests, homogeneity tests, pH tests, specific gravity tests, viscosity tests and displaced volume test. The results of organoleptic tests, homogeneity, pH, specific gravity, viscosity and transferred volume have met the requirements. Analysis using SLD showed that the optimal preparation formula for baby telon tree tea oil (Melaleuca alternifolia Cheel) was obtained with a VCO and Olive Oil composition of 78.4% and 19.6% with a specific gravity response value of 0.906 gr/ml, viscosity 36.84 cp and volume transferred 57.33 ml. In the hedonic testing of baby telon oil preparations, tree tea oil (Melaleuca alternifolia Cheel) with variations of VCO and olive oil from the optimum formula in terms of color was preferred more by the panelists.
Co-Authors Adityas, Hanung Puspita Haryati, Ety NURPATMAWATI, NURPATMAWATI Wulansari, Eka Zakiyah, Fitri