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All Journal Jurnal Kedokteran Hewan Indonesian Health Journal CERATA
Adri, Tenri Ayu
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi Dan Uji Efektivitas Antijamur Sediaan Medicated Shampoo Fraksi Etil Asetat Kunyit (Curcuma Domestica) Terhadap Jamur Malassezia Furfur Penyebab Ketombe Awaliah, Irma Nurul; Adri, Tenri Ayu; Syarif, Hardiyanti; Nadjamuddin, Mirfaidah
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 3 No. 2 (2024): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v3i2.228

Abstract

Penelitian ini dilakukan untuk mengetahui apakah fraksi etil asetat kunyit (Curcuma domestica) dapat di formulasikan menjadi sediaan shampo yang stabil secara fisik dan kimia,, untuk mengetahui apakah sediaan shampo fraksi etil asetat kunyit (Curcuma domestica) dapat menghambat pertumbuhan jamur Malassezia furfur dan untuk mengetahui pada konsentrasi berapakah formulasi sediaan fraksi etil asetat kunyit (Curcuma domestica) memiliki efektivitas antijamur yang optimal. Jenis penelitian ini eksperimental laboratorium menggunakan metode ekstraksi dengan pelarut etanol 96% dan fraksinasi dengan pelarut etil asetat, N-heksan, dan air. Penelitian ini menggunakan tiga konsentrasi yang berbeda yaitu, 15%, 20% dan 25% serta dua kontrol pendukung yaitu kontrol (-) sebagai sediaan shampo tanpa zat aktif dan kontrol (+) yaitu shampo ketomed ketokonazole. Uji organoleptik, uji pH, uji daya sebar, uji viskositas, uji tinggi busa dan uji efektivitas antijamur, dimana baik sebelum maupun setelah cyclingramram test memperlihatkan tidak ada perbedaan bermakna (p>0,05), sehingga disimpulkan bahwa fraksi etil asetat kunyit dapat diformulasikan menjadi sediaan shampo yang stabil secara fisik dan kimia, sediaan shampo antiketombe memiliki efektivitas terhadap pertumbuhan Malassezia furfur dan pada konsentrasi sediaan shampo yang efektif menghambat pertumbuhan Malassezia furfur yaitu 25% dengan kategori sangat kuat.
The Comparison and Test of Antioxidant Activity of Ethanol Extracts of Pangi Leaves and Seeds (Pangium Edule Reinw.) Using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Method Suleman, Abdul Wahid; Sari, Nurmala; Safaruddin, Safaruddin; Adri, Tenri Ayu; Siradjuddin, Mutmainnah; Prihandari, Ayu
CERATA Jurnal Ilmu Farmasi Vol 15 No 2 (2024): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v15i2.988

Abstract

The leaves and seeds of pangi (Pangium edule Reinw.) contain alkaloids, flavonoids, saponins, and tannins, which acts as antioxidants. Antioxidants are needed to protect the body and inhibit the negative impact of free radicals due to the oxidation reactions that occur. Antioxidants are compounds that inhibit oxidation reactions by binding free radicals and molecules. This research aims to determine the comparison of the antioxidants activity of pangi (Pangium edule Reinw.) leaves and seeds using the DPPH (1,1,-Diphenyl-2-Picrylhydrazyl) method. Reactive research method, experimentally, namely by carrying out serial dilutions of concentrations of 10, 20, 30, 40 and 50 ppm in each test solution, then adding the DPPH solution and measuring the antioxidants activity with a UV-Vis Spectrophotometer. After that, the IC50 (Inhibitor Concentration 50) value and the AAI (Antioxidant Activity Index) value are calculated, and the data were analyzed using ANOVA. The results of calculating the IC50 and AAI values are that the IC50 value of the pangi leaf ethanol extract is 49.6061 ppm (AAI=1.007), while the IC50 value of ethanol extract of pangi seeds is 50.2027 (AAI=0.9959). From the results of research and data analysis, it can be concluded that the ethanol extract of pangi leaves has higher antioxidant activity compared to the ethanol extract of pangi seeds.
SUBACUTE TOXICITY TEST OF BEACH CABBAGE [Scaevola taccada (Gaertn.) Roxb.] LEAF EXTRACT ON HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEYS OF WHITE RATS Widati, Aritzah Dwi; Adri, Tenri Ayu; Kabo, Peter; Djabir, Yulia Yusrini
Jurnal Kedokteran Hewan Vol 16, No 2 (2022): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i2.19310

Abstract

The purpose of this study was to evaluate the toxic effects of beach cabbage leaves [Scaevola taccada (Gaertn.) Roxb.]by observing the histopathological changes in the livers and kidneys of male white rats. This study used 20 white rats which were divided into 4 groups: 1 control group and 3 groups receiving treatments in the form of Scaevola taccada leaf ethanolic extract (STLEE) in graded doses (200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW). Toxicity test was performed by administering STLEE for 14 days. The results of daily observations showed that the experimental animals experienced diarrhea. Meanwhile, histopathological observations showed the occurrences of hydropic degeneration, fat degeneration, necrotic liver cells, and dilatation of Bowman's capsule in the animals kidney cells. It was concluded that STLEE at a dose of 200 mg/kg BW is safe to use, but is toxic at a dose of 600 mg/kg BW, both to the livers and kidneys.
Co-Authors Abdul Wahid Suleman Awaliah, Irma Nurul Djabir, Yulia Yusrini Nadjamuddin, Mirfaidah Nurmala Sari Peter Kabo Prihandari, Ayu RR. Ella Evrita Hestiandari Siradjuddin, Mutmainnah Syarif, Hardiyanti Widati, Aritzah Dwi