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All Journal Jurnal Ilmu Kefarmasian Indonesia Indonesian Health Journal
Syarif, Hardiyanti
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi Dan Uji Efektivitas Antijamur Sediaan Medicated Shampoo Fraksi Etil Asetat Kunyit (Curcuma Domestica) Terhadap Jamur Malassezia Furfur Penyebab Ketombe Awaliah, Irma Nurul; Adri, Tenri Ayu; Syarif, Hardiyanti; Nadjamuddin, Mirfaidah
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 3 No. 2 (2024): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v3i2.228

Abstract

Penelitian ini dilakukan untuk mengetahui apakah fraksi etil asetat kunyit (Curcuma domestica) dapat di formulasikan menjadi sediaan shampo yang stabil secara fisik dan kimia,, untuk mengetahui apakah sediaan shampo fraksi etil asetat kunyit (Curcuma domestica) dapat menghambat pertumbuhan jamur Malassezia furfur dan untuk mengetahui pada konsentrasi berapakah formulasi sediaan fraksi etil asetat kunyit (Curcuma domestica) memiliki efektivitas antijamur yang optimal. Jenis penelitian ini eksperimental laboratorium menggunakan metode ekstraksi dengan pelarut etanol 96% dan fraksinasi dengan pelarut etil asetat, N-heksan, dan air. Penelitian ini menggunakan tiga konsentrasi yang berbeda yaitu, 15%, 20% dan 25% serta dua kontrol pendukung yaitu kontrol (-) sebagai sediaan shampo tanpa zat aktif dan kontrol (+) yaitu shampo ketomed ketokonazole. Uji organoleptik, uji pH, uji daya sebar, uji viskositas, uji tinggi busa dan uji efektivitas antijamur, dimana baik sebelum maupun setelah cyclingramram test memperlihatkan tidak ada perbedaan bermakna (p>0,05), sehingga disimpulkan bahwa fraksi etil asetat kunyit dapat diformulasikan menjadi sediaan shampo yang stabil secara fisik dan kimia, sediaan shampo antiketombe memiliki efektivitas terhadap pertumbuhan Malassezia furfur dan pada konsentrasi sediaan shampo yang efektif menghambat pertumbuhan Malassezia furfur yaitu 25% dengan kategori sangat kuat.
Ethanolic extract of Parkia speciosa Hassk leaves innovation of gastroretentive tablet: standardization and optimization Nurfitriyana, Nurfitriyana; Fitriya, Fitriya; Fithri, Najma Annuria; Putri, Dwi Kurnia; Lestari, Siti Marwah; Waluyo, Dyah Ayuwati; Syarif, Hardiyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1461

Abstract

Parkia speciosa ethanol leaves extract contains flavonoid, tannin, and terpen as ulcus peptic remedy. These compounds exhibit limited activity in the stomach due to the short gastric residence time following oral administration. The formulation of gastroretentive tablets can overcome this limitation. This research aims to control the prolonged release of drugs in the stomach to increase bioavailability and characterize the ethanol leaves extract. Extraction was carried out by maceration using ethanol, followed by standardization based on specific and non-specific parameters extract. Gastroretentive tablet was formulated with combination of HPMC-K4M and chitosan using factorial design 22. Effects of compositional factors and their interactions on gastroretentive tablet was observed on hardness, friability, floating lag/duration time, swelling index, and mucoadhesive time. Results standardization extract showed that extract met the required criteria for both specific parameters (organoleptic properties and phytochemical screening) and non-specific parameters (moisture content, loss on drying, water/ethanol-soluble extract content). Based on with DX®10 analysis, the optimum formulation was achieved with 20.25% of HPMC-K4M and 10.26% of chitosan. The analysis of the optimum formulation characteristics was as follows: friability (0.22%), hardness (29.53 N), mucoadhesive time (22.86 hours), floating lag/duration time (27.54 minutes; 12 hours), and swelling index (312.82%). Result revealed that gastroretentive tablets formulated with ethanol extract of Parkia speciosa leaves improve gastric residence duration and promote better bioavailability.
Co-Authors Adri, Tenri Ayu Awaliah, Irma Nurul Dwi Kurnia Putri Dyah Ayuwati Waluyo Fitriya, Fitriya Nadjamuddin, Mirfaidah Najma Annuria Fithri, Najma Annuria Nurfitriyana Nurfitriyana Siti Marwah Lestari