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All Journal Martabe : Jurnal Pengabdian Kepada Masyarakat JURNAL PENELITIAN PERAWAT PROFESIONAL Biological Environment and Pollution Jurnal Farmasetis IMPACT: Journal of Community Service
Mokhamad mahroji
Universitas Bina Bangsa
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Energy Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Biological Environment and Pollution

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Cellular mechanisms of microplastic and nanoparticle exposure and its relationship with metabolic diseases: Literature review Syarifah, Ismi Farah; Hasby, Rizal Maulana; Taupiqurrohman, Opik; Mahroji, Mokhamad
Biological Environment and Pollution Vol. 5 No. 1 (2025)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v5i1.880

Abstract

Microplastics (MP) and nanoparticles (PS-NPs) are emerging environmental contaminants of significant concern due to their adverse effects on human health. This study systematically reviews the impact of these pollutants on cellular mechanisms, with a specific focus on their association with metabolic diseases. Data were collected from various scientific publications relevant to the research topic. Research findings indicate that exposure to microplastics (MP) can result in a reduction in triglyceride and total cholesterol levels, while also disrupting insulin signaling pathways, thereby contributing to insulin resistance. Additional studies have demonstrated that exposure to nanoparticles (PS-NPs) in pregnant mice may increase the risk of metabolic disorders in their offspring. Moreover, PS-NP exposure has been shown to exacerbate type 2 diabetes by inhibiting the AKT/GSK3β pathway. Collectively, exposure to microplastics and nanoparticles has the potential to aggravate metabolic disorders and increase the risk of metabolic diseases, including diabetes, obesity, and cardiovascular conditions. These findings offer valuable insights into the potential health risks associated with environmental exposure to microplastics and nanoparticles and underscore the critical importance of addressing microplastic pollution to human health.
Co-Authors ADI SETIADI Ahmad Alwi Hidayatullah Alwi Hidayatullah, Ahmad Alwy Shihab Arif Hidayat Arif Hidayat Farah Syarifah, Ismi Fatimah, Andini Nur Febsi, Yania Gigin Ginanjar Ismi Farah Syarifah Kurnia, Nia Marlina Nova Tri Handriyanto Rizal Maulana Hasby, Rizal Maulana Setiawan, Yahmin Shihab, Alwy Solihah, Maratu Syarifah, Ismi Farah Taupiqurrohman, Opik Vidya Ayuningtyas Wuri Handayani