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All Journal Indonesian Journal of Medicine Majalah Kedokteran Andalas Asian Australasian Neuro and Health Science Journal (AANHS-J) Folia Medica Indonesiana
Ilyas, Muhana Fawwazy
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Profile of Cognitive Impairement in Patients with Brain Tumors in Dr. Moewardi Hospital, Surakarta Hapsari, Maria Yosita Ayu; Ilyas, Muhana Fawwazy; Ristinawati, Ira; Stepvia, Stepvia; Novika, Revi Gama Hatta
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.798 KB) | DOI: 10.26911/theijmed.2022.7.2.532

Abstract

Background: Brain tumor is a disease that is difficult to treat and causes high morbidity and morta¬lity. One of the clinical manifestations of brain tumors is cognitive impairment which is the most common neurological problem. The aim of this study is to determine the profile of cognitive impairment in patients with brain tumors.Subjects and Method: The design of this study was a retrospective cross-sectional using secondary data from the Neurology Polyclinic of RSUD Dr. Moewardi in January 2021-March 2022. The subject was diagnosed with a brain tumor based on anamnesis, physical examination, and neuroimaging. Cognitive impairment was inferred through the MoCA-Ina test. The analysis used was univariate descriptive analysis, independent T test, Mann-Whitney test, and Pearson correlation test.Results: There were 29 subjects with a mean MoCA-Ina score (17.97). Primary brain tumors (79.3%), more than metastatic tumors. The majority of patients were diagnosed with meningioma (55.2%). This study showed that there were differences in abstraction scores (p=0.015) and total MoCA-Ina scores (p=0.042) between patients with tumors located in the temporal lobe and non- temporal lobe; differences in abstraction scores (p=0.034) and orientation scores (p=0.042) between patients with supratentorial and infratentorial tumors; and differences in memory scores (p=0.028) between patients with and without radiation history. In addition, this study also found an association between the number of lobes affected by brain tumors with attention score (p=0.027; r=-0.409), abstraction score (p=0.004; r=-0.524), orientation score (p=0.021; r=-0.426), and the total score of MoCA-Ina (p=0.018, r=-0.435).Conclusion: There is an association between brain tumors and cognitive impairment which is concluded through the MoCA-Ina test. The clinical manifestations of cognitive impairment in the patient are in accordance with the neuroanatomical function of the brain affected by the lesion.Keywords: Cognitive, Tumor, MoCA-InaCorrespondence: Maria Yosita Ayu Hapsari. Department of Neurology, Faculty of Medicine, Universitas Sebelas Maret/ Moewardi Hospital, Indonesia. Email: ayositahapsari@gmail.com. Phone: 0813 3155 5412.Indonesian Journal of Medicine (2022), 07(02): 242-250https://doi.org/10.26911/theijmed.2022.07.02.12
Perception of online learning with anxiety and stress level among medical students Dewanti, Nanda Derista Ayu; Nugroho, I Gusti Bagus Indro; Lestari, Anik; Yuliadi, Istar; Ilyas, Muhana Fawwazy; Triniputri, Winastari Yarhanim
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p600-608.2023

Abstract

Objective: This study aimed to find out the association between the perception of online learning and anxiety as well as stress levels among medical students. Methods: This is an observational analytic study with a cross-sectional approach. The sample was comprised of 213 undergraduate medical studentsept at Medical Faculty Universitas Sebelas Maret (UNS) and data were collected using total sampling. The study was conducted using the Taylor Manifest Anxiety Scale (TMAS), Perceived Stress Scale (PSS), and perception of online learning questionnaires. Data were analyzed using Chi-square, Cramer’s V, and Kendall tau b test. Results: This study shows a significant correlation between the perception of online learning and anxiety (p=0.049) as well as stress level (p=0.007). Sex also has an association with anxiety (p=0.010) and stress level (p=0.004). Furthermore, female has higher anxiety and stress levels compared to male. Conclusions: Perception of online learning is related to the anxiety and stress level among medical students.
Differences in Aerobic Capacity and Running Speed Across Various Somatotype Structures and Body Fat Compositions among Professional Football Athletes in Indonesia Ghozali, Dhoni Akbar; Ridhallah, Muhammad Syauqi; Shabrina, Syania; Nurhani, Ahmad Isnaini Shidqi; Hastami, Yunia; Rahayu, Dwi; Aryoseto, Lukman; Handayani, Selfi; Munawaroh, Siti; Wiyono, Nanang; Riyanto, Agus Sugeng; Budiono, Enrico Ananda; Rahma, Annisa Aghnia; Ilyas, Muhana Fawwazy
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study emphasizes the significance of understanding professional football players' various somatotype structures and body fat compositions as an important contribution to the area of sports science. This study lays the groundwork for future research to better understand the intricate interactions between somatotype structures, body composition, and athletic performance. 2. Since a one-size-fits-all approach may not be successful, this study advocates for tailored evaluations of training regimens to cater to athletes' unique requirements and skills, which may lead to higher overall performance. Abstract This study investigated the effects of somatotype structures and body fat composition on professional football athletes' aerobic capacities and running speed. This study used an analytical observational design with a cross-sectional approach. The subjects comprised 27 professional football athletes from Bhayangkara Football Club, located in Bekasi, Indonesia. This study measured several variables, i.e., players' age, playing position, somatotype structures assessed using the Somatotype Rating Form and Heath-Carter Somatochart, body fat composition measured using Brozek and Siri formulas, aerobic capacities determined by the maximum rate of oxygen (VO2 max) through the Yo-Yo Intermittent Recovery Test Level 2, and running speed over a 30 m distance. The data were presented as mean ± standard deviation (SD), frequency (n), and percentage. The Shapiro-Wilk was used to determine the normality of the data distribution. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by the post-hoc least significant difference (LSD) test, the Kruskal-Wallis test followed by the post-hoc Mann-Whitney test, as well as the independent t-test, the Mann-Whitney test, and Pearson's or Spearman's correlation tests. A value of p<0.05 was considered statistically significant. The athletes exhibited a predominant somatotype structure of mesomorph-endomorph (88.9%). Notable associations were found between mesomorphy rating and running speed (r=-0.548; p=0.003), body fat composition and aerobic capacity (r=-0.448; p=0.019), as well as age and aerobic capacity (r=-0.515; p=0.006). Notably, differences in aerobic capacity were observed among various age groups (p=0.031). There were also differences in body fat composition (p=0.003) and running speed (p=0.036) between two distinct somatotype structures. These findings underscore the importance of considering individualized training and conditioning programs that account for athletes' unique body compositions and ages.
Effect of L-Citrulline on Creatine Kinase MM (CK-MM) Isoenzymes in Mice: An In Vivo Study Focusing on Immunohistochemistry Analysis Ghozali, Dhoni Akbar; Rahma, Annisa Aghnia; Hanifa, Shafira Nur; Ilyas, Muhana Fawwazy
Folia Medica Indonesiana Vol. 60, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study elucidates the effect of L-citrulline supplementation on creatine kinase MM (CK-MM) expression post-eccentric exercise, offering novel insights into its potential role in mitigating muscle damage. 2. The findings demonstrate that L-citrulline administration significantly reduces CK-MM expression levels in skeletal muscle tissue, suggesting its therapeutic potential in enhancing muscle recovery and performance following exercise-induced damage. 3. This study contributes valuable insights into the multifaceted benefits of L-citrulline supplementation for supporting overall muscle health and performance by identifying its protective effects under different mechanisms, including improved blood flow, antioxidant activity, enhanced mitochondrial function, and promotion of muscle protein synthesis.   Abstract Eccentric exercise often induces muscle injuries in athletes, resulting in impaired performance and prolonged recovery time. Creatine kinase MM (CK-MM) is a biomarker for assessing muscle damage, with elevated levels indicating injury. L-citrulline, an amino acid, has shown promise in enhancing performance and reducing recovery time. However, its specific effect on CK-MM remains unclear. This study utilized immunohistochemistry analysis to investigate the effect of L-citrulline supplementation on CK-MM expression post-eccentric exercise in male BALB/c mice. This in vivo study was conducted with a post-test-only design. A total of 25 mice were divided into two control groups (normal/C1 and negative/C2) and three treatment groups (T1, T2, and T3), each containing five mice. The T1, T2, and T3 groups were daily administered 250, 500, and 1,000 mg/kg bw of L-citrulline for seven days, respectively. All mice, except the C1 group, performed a downhill running procedure. The CK-MM expression in skeletal muscle tissue post-eccentric exercise was assessed using immunohistochemistry analysis. The statistical analysis included the Shapiro-Wilk test for data distribution and the Kruskal-Wallis and Mann-Whitney post-hoc tests for significant differences (p<0.05). The results showed that CK-MM expression in the C2 group (91.00±2.24%) was significantly higher (p=0.008) than that of the C1 group (70.00±10.0%). Subsequently, the T1 (68.00±9.08%, p=0.008), T2 (72.00±7.58%, p=0.008), and T3 (67.00±9.75%, p=0.008) groups exhibited significantly lower expressions than the C2 group. These results were consistent with the role of CK-MM as a marker for muscle damage, and they indicated that L-citrulline might have a protective effect against muscle damage post-eccentric exercise. However, no significant differences were observed among the C1, T1, T2, and T3 groups. In conclusion, L-citrulline supplementation demonstrates promise in attenuating muscle damage following eccentric exercise, as evidenced by reduced CK-MM expression levels. These findings highlight the potential therapeutic role of L-citrulline in enhancing muscle recovery and performance.
Circulating MicroRNA as a Non-Invasive Prognostic Biomarker in Traumatic Brain Injury: A Narrative Review of Current Evidence and Translational Considerations for Resource-Limited Settings Yefri, Rezka Fadillah; Ilyas, Muhana Fawwazy; Wardhana, Aji Wahyu; Kurniawan, Azhar Farisyabdi; Prasetya, Mustaqim; Arham, Abrar
Asian Australasian Neuro and Health Science Journal (AANHS-J) Vol. 8 No. 01 (2026): AANHS Journal
Publisher : Talenta Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/aanhs-j.v8i01.25356

Abstract

Background: Traumatic brain injury (TBI) is a leading cause of neurological morbidity and mortality worldwide, with a disproportionate burden in low- and middle-income countries, including Indonesia. Prognostic assessment continues to rely on clinical scales such as the Glasgow Coma Scale (GCS) and on computed tomography, both of which have limited availability or variable performance in resource-constrained settings. Circulating microRNAs (miRNAs) are small non-coding RNAs notable for their stability in blood and quantifiability using widely available reverse transcription quantitative polymerase chain reaction (RT-qPCR) techniques, and they have emerged as candidate prognostic biomarkers after TBI. Objectives: This narrative review synthesizes current evidence on circulating miRNAs as non-invasive prognostic biomarkers in TBI and examines translational and implementation considerations within the Indonesian and broader low-resource neurosurgical context. Methods: A structured literature search was conducted in PubMed, Scopus, Google Scholar, and Cochrane for English-language human studies published between 2015 and 2024, using the keywords “microRNA”, “traumatic brain injury”, “prognosis”, and “biomarker”. After PRISMA-based screening, 32 studies were retained for narrative synthesis and complemented by foundational methodological references and high-quality reviews. Results: miR-21, miR-146a, miR-155, and miR-124, together with additional candidates such as miR-16, miR-92a, miR-93, miR-191, miR-499, miR-206 and miR-549a-3p, recurrently appeared across studies as associated with injury severity and neurological outcome measured by GCS, Glasgow Outcome Scale (GOS), or its Extended version (GOSE). Multi-miRNA panels generally outperformed individual miRNAs, and models integrating miRNAs with clinical variables reported higher discriminative performance than conventional single protein biomarkers alone. Across studies, the early post-injury window of approximately 24 to 72 hours appeared most informative for prognostication. Major barriers to translation include pre-analytical variability, the absence of consensus normalization strategies, and heterogeneity in analytical platforms and reporting. Conclusions: Circulating miRNAs represent a mechanistically grounded and logistically feasible candidate biomarker class for non-invasive TBI prognostication. Clinical translation will require multicenter validation, consensus pre-analytical and analytical standards, and phased implementation pathways adapted to local infrastructure. In Indonesia, leveraging the molecular diagnostic capacity expanded during the COVID-19 response could accelerate feasibility testing and early-phase clinical validation.
Co-Authors Anik Lestari Arham, Abrar Aryoseto, Lukman Budiono, Enrico Ananda Dewanti, Nanda Derista Ayu Dhoni Akbar Ghozali Hanifa, Shafira Nur Hapsari, Maria Yosita Ayu Hastami, Yunia Istar Yuliadi Kurniawan, Azhar Farisyabdi Luluk Fajria Maulida Maulina, Rufidah Nanang Wiyono Novika, Revi Gama Hatta Nugroho, I Gusti Bagus Indro Nurhani, Ahmad Isnaini Shidqi Nurwijayanti Prasetya, Mustaqim Rahma, Annisa Aghnia Ridhallah, Muhammad Syauqi Ristinawati, Ira Riyanto, Agus Sugeng Sari, Atriany Nilam Selfi Handayani Shabrina, Syania Siti Munawaroh Siti Nurhidayati Stepvia, Stepvia Triniputri, Winastari Yarhanim Wahidah, Nurul Jannatul Wardhana, Aji Wahyu Yefri, Rezka Fadillah