Article Per Year (5 Year)
p-Index From 2021 - 2026
1.203
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Obstetrics & Gynecology Science Devotion: Journal of Research and Community Service Indonesian Journal of Cancer Malahayati International Journal of Nursing and Health Science
Razali, Renardy Reza
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
The Relationship Between Body Mass Index And Anemia An Pregnancy At The Muara Fajar Rumbai Community Health Center, Pekanbaru City Razali, Renardy Reza; Noviardi, Noviardi; Afdanil, Fitra
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.702

Abstract

Introduction: Anemia during pregnancy is a health problem that can be detrimental to the mother and baby, such as premature birth, low birth weight, and even death in the mother. Inappropriate nutritional intake can cause health problems such as malnutrition which can increase risks in pregnancy such as low birth weight, premature birth, and anemia.Method: This study is a cross-sectional study of pregnancy in the first and third trimesters recorded at the Muara Fajar Rumbai Community Health Center, Pekanbaru was conducted in February 2024.Results: This study was conducted with a total research sample of 106 pregnant women. Bivariate analysis showed the relationship between the incidence of anemia and gestational age showed a p-value <0.05. The relationship between BMI and the incidence of anemia in pregnant women was found to be a p-value of 0.001, which indicates that there is a relationship between BMI and the incidence of anemia in pregnant women in the Muara Fajar Community Health Center working area, Pekanbaru City. The variables age, BMI, level of knowledge, and income are the dominant variables in causing the incidence of anemia in pregnancy.Conclusion: Maternal nutritional status as assessed by BMI influences the incidence of anemia in pregnant women, especially in the third trimester.Hubungan Antara Indeks Massa Tubuh dan Anemia Pada Kehamilan di Puskesmas Muara Fajar, Kota PekanbaruAbstrakPendahuluan: Anemia selama kehamilan merupakan masalah kesehatan yang dapat merugikan ibu dan bayi seperti kelahiran prematur, berat badan lahir rendah, hingga menyebabkan kematian pada ibu. Asupan gizi yang tidak sesuai dapat menyebabkan masalah kesehatan seperi malnutrition yang dapat meningkatkan risiko pada kehamilan seperti berat bayi lahir rendah kelahiran prematur dan anemia.Metode: Penelitian ini merupakan penelitian cross sectional pada ibu hamil trismester I dan III yang terdata di Puskesmas Muara Fajar Rumbai Kota Pekanbaru yang dilakukan pada bulan Februari 2024.Hasil: Penelitian ini dilakukan dengan total sampel penelitian berjumlah 106 orang ibu hamil. Analisis bivariate menunjukkan hubungan antara kejadian anemia dan usia kehamilan menunjukkan p-value < 0,05. Hubungan antara IMT dan kejadian anemia pada ibu hamil diperoleh p-value 0.001 yang menunjukkan bahwa terdapat hubungan IMT dengan kejadian anemia pada ibu hamil di wilayah Kerja Puskesmas Muara Fajar Kota Pekanbaru. Variabel usia, IMT, tingkat pengetahuan, dan penghasilan menjadi variabel yang dominan dalam mengakibatkan kejadian anemia pada kehamilan.Kesimpulan: Status gizi ibu yang dinilai dari IMT memengaruhi kejadian anemia pada ibu hamil terutama pada trimester ke-III.Kata kunci: Kehamilan, Status Gizi, Indeks Massa Tubuh, Anemia 
The risk of malignancy index (RMI) in diagnosis of ovarian malignancy: A case report Sembiring, Daniel Anugrahta; Razali, Renardy Reza
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 1 (2025): Volume 8 Number 1
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i1.664

Abstract

Background: Ovarian cancer is among the deadliest gynecological cancers, with nearly 70% of cases identified at an advanced stage. It is the fourth most common cause of cancer-related deaths in women. While early detection significantly improves ovarian cancer outcomes, the disease often presents no symptoms in its early stages, resulting in delayed diagnosis and worsened prognosis. Achieving an accurate initial diagnosis in women with ovarian cancer is essential for ensuring early, correct treatment and reducing the risk of overtreatment. Clinically, various methods are available to assess ovarian malignancy risk, including the Risk of Malignancy Index (RMI). Purpose: To demonstrate the use of the RMI score to differentiate between benign and malignant ovarian tumors. Method: The case of Mrs. LKS, a 34-year-old woman who had experienced abdominal distension and related symptoms for one year, was analyzed in detail. The patient underwent multiple diagnostic evaluations, including a physical exam, ultrasound, abdominal CT scan, and histopathological analysis. The RMI, a well-established malignancy risk assessment tool, was employed. The initial evaluation of ovarian malignancy risk primarily considered ultrasound results, menopausal status, and serum CA-125 levels, with an RMI score above 200 indicating a high risk of ovarian cancer. Surgical procedures performed included a total hysterectomy, omentectomy, appendectomy, and ascitic fluid drainage. Results: The patient’s main issue was a gradually worsening abdominal distension over the past year, accompanied by lower abdominal pain, nausea, and significant weight loss. Physical examination and imaging revealed a heterogeneous cystic mass in the abdomen, suggesting a malignant ovarian cyst, along with the presence of ascites. The RMI score exceeded 200, indicating a high risk of ovarian malignancy. The patient underwent a laparotomy, which included a total hysterectomy, omentectomy, and appendectomy, leading to a postoperative diagnosis of stage III B ovarian cancer. Despite the intervention, the prognosis remained poor (dubia ad malam) due to the advanced stage at diagnosis. Conclusion: The RMI calculation serves as a valuable and reliable method for guiding diagnostic, management, and treatment decisions for patients with benign and malignant ovarian masses.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Diagnostic Accuracy of CA-125 Levels for Ovarian Tumor Patients with Suspected Malignancy Pangaribuan, Machyuddin Tumpak Marojahan; Razali, Renardy Reza; Darmawi, Darmawi
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1159

Abstract

Background: Ovarian cancer is a deadly gynecological cancer that appears in ovarian tissue. To detect earlier stages of ovarian cancer and prevent unnecessary surgery, an examination and screening strategy with higher sensitivity and specificity levels are needed. The CA-125 examination is available at Arifin Achmad Hospital and has often been performed on ovarian tumor patients with suspected malignancy. Currently, the accuracy of the CA-125 examination still raises debate in diagnosing malignant ovarian tumors. This study aims to determine the diagnostic accuracy of CA-125 levels in diagnosing ovarian cancer in ovarian tumor patients with suspected malignancy at Arifin Achmad Hospital. Method: This research is an analytical diagnostic test study with a cross-sectional approach, using secondary data recorded from medical records from 2019 to 2022 on ovarian tumor patients with suspected malignancy at Arifin Achmad Regional Hospital.Results: The diagnostic accuracy of CA-125 levels in ovarian cancer is 94.5%, the optimal cut-off value is 36.5 IU/ml, the sensitivity is 86.1%, the specificity is 90.1%, the positive predictive value is 89.4%, the negative predictive value 86.9%. The results of the study showed that there was a significant age difference between benign ovarian tumors and ovarian cancer. The most common histopathological feature of benign ovarian tumors is serous cystadenoma. The most common histopathological feature of malignant ovarian tumors is serous adenocarcinoma. There is a significant relationship between CA-125 levels and ovarian tumors.Conclusion: The identification of CA-125 levels in diagnosing ovarian cancer in ovarian tumor patients with suspected malignancy was a promising test with high diagnostic accuracy level
Case Analysis of Cesarean Scar Pregnancy (CSP) in G3P2A0H2 Gravid at 16-17 Weeks with A History of Two Previous Cesarean Sections Alhudri, M. Ardaris; Ardiani, Vani; Razali, Renardy Reza
Devotion : Journal of Research and Community Service Vol. 7 No. 2 (2026): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v7i2.25635

Abstract

Cesarean Scar Pregnancy (CSP) is a rare but serious form of ectopic pregnancy with an increasing incidence corresponding to rising cesarean delivery rates. It carries significant risks of massive hemorrhage and uterine rupture. This case report presents a 33-year-old woman (G3P2A0H2) at 16–17 weeks of gestation with two prior cesarean sections, who presented with vaginal spotting. Transvaginal ultrasound revealed a 6.08 × 6.03 cm complex mass in the lower uterine segment consistent with CSP. Initial management with a single-dose methotrexate (50 mg/BSA) regimen was unsuccessful, as bleeding persisted and the mass enlarged to 6.9 × 5.9 cm on follow-up ultrasound. Surgical intervention via CSP resection laparotomy with hysterorrhaphy and Pomeroy bilateral tubectomy was subsequently performed, with an estimated blood loss of approximately 800 cc. The patient recovered well postoperatively, and histopathological examination confirmed the presence of trophoblastic tissue. This case underscores the diagnostic challenges and management complexities associated with advanced CSP. Medical therapy with methotrexate may be ineffective in later gestational stages, necessitating timely surgical intervention to prevent life-threatening complications. Counseling on permanent contraception is essential due to the high recurrence risk. This report highlights the importance of early clinical suspicion, accurate imaging, and multidisciplinary management to optimize outcomes for CSP, particularly in patients with multiple prior cesarean deliveries.
OSCS (One Step Conservative Surgery) vs MOSCUS (Modified One Step Conservative Uterine Surgery) for Placenta Accreta Spectrum (PAS) Surgery, Which One Is More Preferred? A Literature Review Anakita, Cantika; Simanjuntak, Arya Marganda; S., Donel; Noviardi, Noviardi; Razali, Renardy Reza
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.898

Abstract

Introduction: Placenta Accreta Spectrum (PAS) is a severe obstetric complication causing hemorrhage, maternal morbidity, and mortality. Two widely adopted approaches to treatment are OSCS and MOSCUS. This literature review compares OSCS and MOSCUS to provide evidence-based insights for optimizing PAS treatment.Objective: This study aims to compare the preferred conservative uterine surgical approaches in the management of Placenta Accreta Spectrum (PAS).Methods: A literature review was undertaken following the scale assessment of narrative review articles (SANRA). We utilized various databases to evaluate current evidence for OSCS and MOSCUS in treating PAS. Relevant articles were reviewed to perform a comparative analysis between OSCS and MOSCUS in order to address the objective.Result: The key difference between OSCS and MOSCUS lies in bleeding control by optimal uterine reconstruction with transverse b-lynch suture and selective vascular ligation. While OSCS is ideal for simpler cases due to its efficiency and practicality, MOSCUS is better suited for complex PAS cases, offering reduced complications and improved outcomes.Conclusion: MOSCUS may be preferable to OSCS in terms of technique with optimal uterine reconstruction by adding several techniques to potentially preserve the uterus. More comparative research between the two required to evaluate the results prospectively. AbstrakPendahuluan: Placenta Accreta Spectrum (PAS) merupakan komplikasi obstetri berat yang menyebabkan perdarahan, morbiditas dan mortalitas ibu. Dua pendekatan yang banyak diadopsi adalah OSCS dan MOSCUS. Tinjauan literatur ini membandingkan OSCS dan MOSCUS untuk memberikan wawasan berbasis bukti untuk mengoptimalkan tatalaksana PASTujuan: Penelitian ini bertujuan untuk membandingkan pilihan tindakan bedah uterus konservatif yang lebih disukai dalam penatalaksanaan Placenta Accreta Spectrum (PAS).Metode: Metode yang digunakan dalam penelitian ini adalah tinjauan literatur yang mengikuti penilaian kualitas SANRA. Kami menggunakan berbagai basis data untuk mengevaluasi bukti terkini OSCS dan MOSCUS dalam tatalaksana PAS. Artikel didiskusikan untuk membuat tinjauan yang komprehensif dan membuat analisis komparatif antara OSCS dan MOSCUS untuk menjawab tujuan penelitian.Hasil: Perbedaan antara OSCS dan MOSCUS bergantung pada kontrol perdarahan dengan rekonstruksi uterus yang optimal dengan jahitan b-lynch melintang dan ligasi pembuluh darah selektif. OSCS ideal untuk kasus-kasus yangKesimpulan: MOSCUS dapat menjadi pilihan dibandingkan dengan OSCS dalam hal teknik dengan rekonstruksi rahim yang optimal dengan menambahkan beberapa teknik yang berpotensi mempertahankan rahim. Penelitian komparatif lebih lanjut antara keduanya diperlukan untuk mengevaluasi hasilnya secara prospektif. 
Co-Authors Alhudri, M. Ardaris Anakita, Cantika Ardiani, Vani Darmawi . Fitra Afdanil Lalu Muhammad Irham Nathania, Auren Noviardi Noviardi, Noviardi Pangaribuan, Machyuddin Tumpak Marojahan S, Donel S., Donel Sembiring, Daniel Anugrahta Simanjuntak, Arya Marganda Suhandri, Wiwin Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Zahra, Leina Putri