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All Journal Pharmaciana: Jurnal Kefarmasian JKPK (Jurnal Kimia dan Pendidikan Kimia)
Hanuriansyah, Yavi
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Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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The effect of syrup simplex concentration on the physicochemical stability of Gembili’s inulin (Dioscorea esculenta (Lour.) Burkill) nanosilver colloid Ermawati, Dian Eka; Hanuriansyah, Yavi
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26569

Abstract

Gembili tuber's inulin is a successful bioreductor agent that forms a nanosilver with a size of 481.4 nm and is stable for 30 days at 4 °C storage. That nanosilver has immunomodulatory activity and is proven safe from the results of acute toxicity tests at a dose of 4 mg/kgBB. However, a drug delivery system is needed to be developed as a supplement product. The syrup was chosen because it is free of alcohol, has a better taste, measured dose, and stability of the active substance compared to elixir, solution, and suspension. Simplex syrup as a syrup base affects stability because it has the potential to form crystals during storage. This research aims to determine the effect of simplex syrup concentration on the stability of nanosilver syrup. The research was conducted with the biosynthesis process using gembili's inulin, nanosilver characteristic, modified syrup formula, and stability test. Nanosilver syrup was prepared by modifying the simplex syrup concentration of 20%, 40%, and 60%. Nanosilver was added at 4 mg/KB b.w, then tested the physicochemical; stability, including organoleptic, pH, and viscosity, before and after storage with temperature variations of 4 °C and 40 °C for six cycles. The best formula then analysis of sugar reduction content and FT-IR. Data analysis using SPSS 21.0 Windows with One-way ANOVA test, Post Hoc, and Paired T-Test. The results showed that the concentration of simplex syrup affected consistency, pH, and viscosity. The simplex syrup concentration of 60% met the requirement with a medium thick consistency, pH 5.25±0.03, a viscosity of 92±2.6 cps, reducing sugar content was 20.59% ±0.002, and the FTIR profile showed that it still contained nanosilver which was indicated by the presence of Ag-N groups compared to silver nitrate solution.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Ermawati, Dian Eka; Hanuriansyah, Yavi; Susanto, Nindita Clourisa Amaris; Rochmani, Sholichah; Utami, Diyah Tri; Zulpadly, M. Fiqri; Sasongko, Heru; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Untari, Meta Kartika
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Co-Authors Darojati, Ulfa Afrinurfadhilah ERMAWATI, DIAN EKA Heru Sasongko Meitasari, Annisa Diyan Rochmani, Sholichah Susanto, Nindita Clourisa Amaris untari, meta kartika Utami, Diyah Tri Zulpadly, M. Fiqri