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The Effect of Temperature on Physicochemical Properties of Moringa Leaf Ethanolic Extract (Moringa oleifera L.) Patch and Anti-Inflamatory Test Ermawati, Dian Eka; Hidayati, Astri; Untari, Meta Kartika
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13527

Moringa leaf extract contains flavonoids confirmed as anti-inflammatory at 200 mg/Kg b.w. The patch was chosen for topical anti-inflammatory preparation because it is continuous for an extended treatment period. Previous research has developed a patch formula using a polymer combination of polyvinyl alcohol (PVA) and alpha-cellulose (1: 2) that meets the requirements for good patch preparation. However, the effect of temperature resistance on physicochemical properties and anti-inflammatory activity needs to be confirmed. Moringa leaves were macerated in 96% ethanol and dispersed into a patch matrix of PVA and alpha-cellulose. Patches were treated at various storage temperatures, namely 4°C, 25°C, and 40°C each for 8 hours for six cycles. Mice were divided into three groups: blank patch, brand patch product, and moringa leaf patch. Mice were given 0.05 mL of carrageenan suspension intraplanar on the sole of the left foot, and the edema volume was measured using a plethysmometer. Statistical analysis uses One-Way ANOVA and T-test. The results showed that temperature affected the pH, thickness, and weight properties but did not affect the moisture, folding endurance, and organoleptic properties. The average edema volume of mice in the brand product group was not significantly different from the moringa leaf patch group, with a significance value of 0.066 (p > 0.05). The Moringa leaf ethanolic extract patch confirmed it can reduce the volume of mouse foot edema by 5 hours.

PENGEMBANGAN PRODUK TEH HERBAL BERBAHAN DASAR TOGA BERSAMA KWT BAGAS WARAS Susanto, Nindita Clourisa Amaris; Rohmani, Sholichah; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyah; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika
JCES (Journal of Character Education Society) Vol 6, No 4 (2023): Oktober
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jces.v6i4.16741

Abstrak: Kelompok Wanita Tani (KWT) Bagas Waras merupakan kelompok produktif yang berfokus pada Tanaman Obat Keluarga (TOGA) dari pembibitan hingga pengolahan pasca panen. Kelompok Wanita Tani (KWT) Bagas Waras telah mengembangkan TOGA menjadi beberapa produk olahan makanan seperti keripik dan kue kering dan produksi dalam bentuk simplisia kering. KWT membutuhkan produk inovasi lain yang dapat mendukung dalam pengembangan pemnfaatan TOGA. Tim pengabdian memberikan transfer ilmu dalam pembuatan teh herbal untuk menjadi salah satu produk inovasi yang dapat dikembangkan oleh ibu-ibu di KWT Bagas Waras. Pelaksanaan pengabdian dilakukan dengan melibatkan ibu-ibu anggota KWT Bagas Waras sebanyak 25 orang melalui beberapa tahapan yaitu persiapan, pelatihan dan evaluasi. Kegiatan pengabdian kepada masyarakat ini diharapkan dapat mengenalkan teh herbal dengan campuran beberapa jenis TOGA dan dilakukan pengemasan dalam bentuk teh celup. Kegiatan pengabdian kepada masyarakat yaitu pelatihan pembuatan teh herbal telah terlaksana dengan baik. Kegiatan mendapatkan respon yang baik dari KWT Bagas Waras dan peserta antusias. Hasil kegiatan diperoleh 3 varian produk teh herbal dengan bahan dasar TOGA.Abstract: Bagas Waras Women Farmers Group (KWT) is a productive group that focuses on Family Medicinal Plants (TOGA) from nursery to post-harvest processing. Bagas Waras Women Farmers Group (KWT) has developed TOGA into several processed food products such as chips and pastries and production in the form of dry simplisia. KWT needs other innovative products that can support the development of TOGA utilization. The service team provided knowledge transfer in making herbal tea. The implementation of the service was carried out by involving 25 women members of KWT Bagas Waras through several stages, namely preparation, training and evaluation.. This community service activity is expected to introduce herbal tea with a mixture of several types of TOGA and packaging in the form of tea bags. Community service activities, namely training in making herbal tea, have been carried out well. The activity received a good response from KWT Bagas Waras and enthusiastic participants.

The Effect of Temperature on Physicochemical Properties of Moringa Leaf Ethanolic Extract (Moringa oleifera L.) Patch and Anti-Inflamatory Test Ermawati, Dian Eka; Hidayati, Astri; Untari, Meta Kartika
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13527

Moringa leaf extract contains flavonoids confirmed as anti-inflammatory at 200 mg/Kg b.w. The patch was chosen for topical anti-inflammatory preparation because it is continuous for an extended treatment period. Previous research has developed a patch formula using a polymer combination of polyvinyl alcohol (PVA) and alpha-cellulose (1: 2) that meets the requirements for good patch preparation. However, the effect of temperature resistance on physicochemical properties and anti-inflammatory activity needs to be confirmed. Moringa leaves were macerated in 96% ethanol and dispersed into a patch matrix of PVA and alpha-cellulose. Patches were treated at various storage temperatures, namely 4°C, 25°C, and 40°C each for 8 hours for six cycles. Mice were divided into three groups: blank patch, brand patch product, and moringa leaf patch. Mice were given 0.05 mL of carrageenan suspension intraplanar on the sole of the left foot, and the edema volume was measured using a plethysmometer. Statistical analysis uses One-Way ANOVA and T-test. The results showed that temperature affected the pH, thickness, and weight properties but did not affect the moisture, folding endurance, and organoleptic properties. The average edema volume of mice in the brand product group was not significantly different from the moringa leaf patch group, with a significance value of 0.066 (p > 0.05). The Moringa leaf ethanolic extract patch confirmed it can reduce the volume of mouse foot edema by 5 hours.

Pelatihan Pembuatan Lulur Tradisional Berbahan Dasar TOGA di Kelompok Wanita Tani (KWT) Bagas Waras Boyolali: Training on Making Traditional Scrubs Based on TOGA at KWT Bagas Waras Boyolali Darojati, Ulfa Afrinurfadhilah; Rohmani, Sholichah; Sasongko, Heru; Susanto, Nindita Clourisa Amaris; Zulpadly, M. Fiqri; Utami, Diyah Tri; Meitasari, Annisa Diyan; Untari, Meta Kartika; Ermawati, Dian Eka; Artanti, Anif Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 9 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i9.8562

The Bagas Waras Women's Farmers Group (KWT) is one of the women's groups that cultivates a lot of TOGA in Banyuanyar Village, Boyolali. Their seriousness in cultivating TOGA is proven by the establishment of Omah TOGA, which has become an educational tourism destination. KWT members also have high enthusiasm for developing TOGA's potential and have produced many processed food products from TOGA. KWT Bagas Waras needs innovations in TOGA products, namely traditional cosmetic products. The service team provides scientific insight through training on developing traditional cosmetic products, namely body scrubs made from various types of TOGA. This activity involves 40 KWT members who will participate in a series of stages: preparation, training, practice, and evaluation. This training activity can increase the scientific insight of KWT members and help them develop traditional body scrubs made from TOGA and good packaging methods. This training has gone well, with all participants very enthusiastically listening to material related to traditional cosmetics and demonstrating how to make body scrubs. The results obtained are traditional body scrubs with various variants originating from TOGA.

Physicochemical Characterization, Cytotoxic Activity, and Caspase-9 Expression of Nanogold-Parijoto (Medinilla Speciosa Reinw .Ex, Bl ) in Hela Cell Lines Artanti, Anif Nur; Rohmani, Sholichah; Prihapsara, Fea; Utami, Diyah Tri; Amaris Susanto, Nindita Clourisa; Zulphadly, M.Fiqri; Meitasari, Annisa Diyan; Darojati, Ulfa Afrinurfadhilah; Untari, Meta Kartika; Sasongko, Heru; Ermawati, Dian Eka
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp175-185

Parijoto (Medinilla speciosa, Reinw. ex. Bl.), a tropical plant native to Southeast Asia, contains flavonoids, tannins, and saponins, which have the potential as an anticancer. Gold nanoparticle-based drug formulations are applied to increase the anticancer effectiveness of herbal medicines. The compounds in the stalk of parijoto have the potential to be bioreductor in the biosynthesis of gold nanoparticles. This study aims to determine the physicochemical characterization, cytotoxic activity, and expression of protein caspase-9 after treatment with nanogold parijoto (AuNPs-PR) on HeLa cell. The nanogold biosynthesis process was done by reacting 1 mM HAuCl4 with parijoto aqueous extract (EP). Physicochemical characterization measure of particle size, Polydisperse Index (PdI), and zeta potential of AuNPs-PR was carried out using a particle size analyzer. The cytotoxic effect and viability cell of AuNPs- PR were carried out using the MTT assay. The expression of caspase-9 was observed by immunocytochemistry assay. Physicochemical characterization of AuNPs-PR shows that the particle size value is 160.8 nm with PdI and zeta potential values of 0.430 and -4.56 mV respectively. In the MTT assay, both AuNPs-PR and EP demonstrated a reduction in the viability of Hela cells after 24 h in a dose-dependent manner, yielding IC50 values of 3.28 μg/mL and 19.22 μg/mL, respectively. AuNPs-PR and EP showed low cytotoxic activity against Vero normal cells, with IC50 values of over 500 μM. Further, the immunocytochemistry assay indicated that there was upregulation of caspase-9 by their expression. These results indicate that AuNPs-PR could effectively induce apoptosis in HeLa cells by upregulating caspase-9.Keywords: caspase-9, HeLa cells, MTT, nanogold, parijoto.

Studi Rasionalitas Penggunaan Obat dengan 10 Penyakit Terbanyak di Puskesmas X Karanganyar Untari, Meta Kartika; Putri, Hapsari Duanda; Qutratu'ain, Syahla; Ermawati, Dian Eka
Jurnal Farmasi Klinik dan Sains Vol 5, No 1 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i1.1702

Definisi Penggunaan Obat Rasional (POR) menurut Organisasi Kesehatan Dunia (WHO) adalah bila pasien mendapatkan pengobatan sesuai dengan kebutuhannya, mendapatkkan obat sesuai dosis serta mendapatkannya dalam periode yang sesuai dengan biaya sesuai jangkauan pasien ataupun masyarkat lain. Terdapat indikator yang digunakan dalam menentukan keberhasilan obat yang rasional berdasarkan Kementerian Kesehatan salah satunya indikator peresepan dan kriteria pengobatan. Untuk menilai rasionalitas antidiabetes digunakan ketepatan indikasi, dosis, durasi, dan frekuensi pemberian dengan menggunakan Pedoman PERKENI. Selain itu, penelitian ini juga bertujuan untuk mengetahui persentase penggunaan antibiotik dan injeksi untuk diagnosis tertentu, serta jumlah rata-rata item obat per resep pasien berdasarkan standar Kementerian Kesehatan RI. Dengan mengumpulkan data sekunder dari rekam medis pasien yang dirawat antara bulan Maret dan Mei 2023, didapatkan bahwa penggunaan antibiotik sudah sesuai standar Kemenkes RI; untuk infeksi saluran pernapasan akut non-pneumonia 18,30%, diare non-spesifik 7,69%, penggunaan injeksi untuk myalgia adalah 0%, dan jumlah rata-rata item obat per lembar resep adalah 2,24%. Sedangkan ketepatan penggunaan obat antidiabetes oral pada pasien diabetes melitus tipe 2 adalah 100% rasional untuk indikasi dan frekuensi pemberian, 79,57% rasional untuk dosis, dan 64,52% rasional untuk ketepatan obat.

Evaluation of Virgin Coconut Oil Concentration Variations in Emulgel Formulations of Garlic (Allium sativum L.) Extract as an Antibacterial Hand Sanitizer Rohmani, Sholichah; Fitria, Krismona Rizky Nur; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Aratanti, Anif Nur; Untari, Meta Kartika
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

One of the effective ways to stay healthy is maintaining cleanliness, including hand hygiene. Various diseases can be easily transmitted through the hands. However, modern developments have changed the habit of handwashing with water to using hand antiseptics. Hand sanitizer is an alternative to overcome this problem. Unfortunately, some hand sanitizer gels on the market still contain alcohol as an antibacterial ingredient. It is necessary to innovate in making hand sanitizers using non-alcoholic ingredients as antibacterials, for example, natural ingredients like garlic. Garlic contains allicin that functions as an antibacterial. Meanwhile, VCO contains high lauric acid with antibiotic properties that function as antiviral, antibacterial, and antiprotozoal. It also contains capric acid, with antiviral and antibacterial functions. This study aims to examine the effect of concentration variation of VCO on the physical stability of garlic extract emulgel preparation and antibacterial effectiveness against the growth of Staphylococcus aureus. The concentration variation of VCO in this study was 3%, 5%, and 7% for 3 types of formulas. The results showed that the concentration variation of VCO in emulgel preparations gave differences in the physical properties of the gel, including pH, viscosity, adhesive strength, and spreadability. It can be concluded that the higher the VCO concentration, the higher the pH, viscosity, and adhesive power, and the lower the spreadability and antibacterial inhibition power against Staphylococcus aureus. The best result from the evaluation of physicochemical properties and antibacterial tests was Formula 1, although it was still in the weak inhibitory power category.

Characterization and In Vivo Evaluation of Durian Peel Extract Nanoliposome Transdermal Patch on Wound Healing Susanto, Nindita Clourisa Amaris; Putri, Milkazia Elda; Utami, Dayinta Tyas; Ermawati, Dian Eka; Sasongko , Heru; Rohmani , Sholichah; Artanti, Anif Nur; Utami, Dyah Tri; Zulpadly Mh, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari , Annisa Diyan; Untari, Meta Kartika; Izza, Alfina
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.48779

Wounds are a form of continuity damage due to loss of tissue, structure and anatomical function of the skin caused by heat trauma or sharp object scratches. The prevalence of wound injury patients in Indonesia is 9.2%. One of the natural ingredients that is effective in inhibiting the growth of infectious organisms is durian, especially in its skin. In this study, durian peel was formulated in liposome dosage form and applied to patch preparations. The purpose of this study was to assess the effectiveness of durian skin extract liposomes (Durio zibethinus Murr.) on wound healing in white rats. The results of this study are that the patches produced can provide a therapeutic effect on the healing of incision wounds in wistar strain male white rats (Rattus norvegicus L.) with a healing percentage on day 7 of 72.5% which is characterized by the absence of edema, bleeding, growth of fur in mice, the appearance of scabs and wound closure.

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