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All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Biosaintifika: Journal of Biology & Biology Education
Yusniasari, Putri Antika
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Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Public Health Social Sciences

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In Silico Study of Cladosporol and Its Acyl Derivatives as Anti-Breast Cancer Against Alpha-Estrogen Receptor Herdiansyah, Mochammad Aqilah; Ansori, Arif Nur Muhammad; Kharisma, Viol Dhea; Alifiansyah, Mochamad Radika Tory; Anggraini, Dhea; Priyono, Qiara Amelia Putri; Yusniasari, Putri Antika; Fetty, Amelia Julia Tria; Zainul, Rahadian; Rebezov, Maksim; Kolesnik, Evgeniy; Maksimiuk, Nikolai
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.949

Abstract

Breast cancer is a chronic health problem that causes 690,000 deaths worldwide. The development of secondary metabolite compounds from natural preparations through an in silico approach is needed as a predictive tool to prevent breast cancer, one of them is cladosporol from Cladosporium spp. This study aims to utilize an in silico approach to predict the potential of cladosporol against alpha-estrogen receptors. The alpha-estrogen receptor with code 6CBZ was selected based on group function as pharmacophore in ligand-receptor interaction. The methods used in this study are by using an in silico approach with Molegro Virtual Docker (MVD) Ver 5.5 for the docking process and CABS-flex 2.0 for identifying the stability of the complexes. ADMET properties analysis was also performed to know the pharmacokinetics attributes of cladosporol. Based on research conducted, stated that cladosporol octanoate has the lowest rerank score with a -84.3593 value and the RMSD value is 1.195 Å so it’s valid for molecular docking. Exploration of cladosporol for anti-breast cancer from Cladosporium spp fungi can be a novelty for the development of future pharmaceutical research. Thus, the development of anti-cancer drugs for early prevention can be carried out to reduce the number of breast cancer cases worldwide.
Pemanfaatan Teh dan Rempah-rempah Khas Indonesia dalam Pemeliharaan Kesehatan Warga di Sumba Timur Menghadapi Pandemi Covid-19: Tea and Indonesian Spices for Improving Health for People in East Sumba for Facing Pandemic COVID-19 Sulistyowaty, Melanny Ika; Purwanto, Djoko Agus; Agil, Mangestuti; Ekowati, Juni; Isadiartuti, Dewi; Hendradi, Esti; Purwitasari, Neny; Yusniasari, Putri Antika
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i4.7043

Abstract

The coronavirus (SARS-CoV-2) has infected nearly 4 million people worldwide. This virus was first identified in Wuhan, China, in December 2019. Every day positive cases of Covid-19 are increasing in the world. Experts are still trying to find a vaccine to prevent this virus, one of which is by increasing the body's resistance (immunity). The use of family medicinal plants (TOGA) or tea, a drink that we usually drink every day is believed to increase one's body immunity. The content of natural chemicals in tea such as EGCG and curcumin found in the rhizomes have antioxidant activity and is clinically proven to increase a person's immunity.
Co-Authors Adi Sofyan Ansori, Muhammad Alifiansyah, Mochamad Radika Tory Anggraini, Dhea Dewi Isadiartuti Djoko Agus Purwanto Esti Hendradi Fetty, Amelia Julia Tria Herdiansyah, Mochammad Aqilah Juni Ekowati Kharisma, Viol Dhea Kolesnik, Evgeniy Maksimiuk, Nikolai Mangestuti Agil Melanny Ika Sulistyowaty Priyono, Qiara Amelia Putri Purwitasari, Neny Rahadian Zainul Rebezov, Maksim