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All Journal Pharmaciana: Jurnal Kefarmasian Bioscientist : Jurnal Ilmiah Biologi
Azhar, Afra Wafiqah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Social Sciences

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Aktivitas Antibakteri Ekstrak Daun Mangrove (Rhizophora mucronata) pada Bakteri Helicobacter pylori Penyebab Tukak Lambung Pertiwi, Reza; S, Salprima Yudha; Wibowo, Risky Hadi; Notriawan, Doni; Nasution, Riski Padilah; Azhar, Afra Wafiqah
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.9957

Abstract

Mangrove (Rhizophora mucronata) is a plant that can be used as an antibacterial because it contains several secondary metabolite compounds such as saponins and flavonoids which can inhibit bacterial growth. This research aims to determinehe antibacterial activity of mangrove leaves (Rhizophora mucronata) in inhibiting the growth of Helicobacter pylori bacteria. This research is an in vitro study using the agar dilution method for 2-5 days. The treatment groups consisted of negative, positive (co-trimoxazole), ethanol extract of mangrove leaves (Rhizophora mucronata) with concentrations of6.25%, 12.5%, 25% and 50%. The treatment was carried out by adding the Helicobacter pylori suspension to a petri dish containing agar media. Observations were made to see whether bacteria grew in the media. The data is then analyzed and broken down from the results of calculating the diameter of the inhibition zone. The test results showed that the ethanol extract of mangrove leaves (Rhizophora mucronata) had antibacterial activity in the weak category in inhibiting the growth of Helicobacter pylori bacteria. This antibacterial activity can be caused because mangrove leaves (Rhizophora mucronata) contain secondary metabolite compounds with an antibacterial mechanism of action, so this is in line with the results of this study.
Assessment of the subchronic toxicity of ethanol extract of Merdeka-leaves (Chromolaena odorata L.) on SGOT, SGPT, and histological alterations in the kidneys and liver of male rats Pertiwi, Reza; Azhar, Afra Wafiqah; Dominica, Dwi; Yudha, Salprima; Rahmawati, Reza; Putri, Yona Harianti
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30278

Abstract

The Merdeka plant (Chromolaena odorata L.) is known for its various pharmacological benefits, including gastroprotection, antibacterial, antihyperglycemic effects, and wound healing promotion. To ensure safe use in the community, it is important to evaluate its potential toxicity. This study examined the effects of ethanol extract of Merdeka leaf (C. odorata) on liver function by measuring the levels of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvate transaminase (SGPT) in male rats (Rattus norvegicus). Twenty-five male Wistar rats were split into five groups: three treatment groups that received ethanol extract at doses of 150 mg/kg BW, 300 mg/kg BW, and 600 mg/kg BW, a negative control group that received 0.5% Na CMC, and a normal control group that received no treatment. For 28 days, the extract was taken orally every day. Following surgery, liver and kidney tissues were removed for histology on day 29, and blood samples were obtained via the aorta. The findings demonstrated that rats administered 600 mg/kg BW of ethanol extract had significantly greater SGOT and SGPT levels than controls (p < 0.05), suggesting that high dose of Merdeka leaf extract may have an impact on kidney and liver functions.
Co-Authors Dominica, Dwi Nasution, Riski Padilah Notriawan, Doni Putri, Yona Harianti Rahmawati, Reza Reza Pertiwi SALPRIMA YUDHA S Wibowo, Risky Hadi