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Apoptotic Index Fails to Predict Chemoresponse in Breast Cancer Siregar, Kamal Basri
Sumatera Medical Journal Vol. 2 No. 2 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

The responsiveness of neoadjuvant chemotherapy in Triple Negative Breast Cancer (TNBC) needs determination to prevent overtreatment with chemoresistance regimen. A total of 60 consented patients from Haji Adam Malik and Bunda Thamrin Hospital were included in this cohort prospectie study. Patients with heart, kidney, liver disease, history of surgery, chemotherapy, or hormonal therapy were excluded. Apoptotic indexes were taken from all subjects before and after neoadjuvant chemotherapy. After 3 cycles of neoadjuvant chemotherapy, 31 subjects (51.7%) did not show clinical response while 29 subjects (48.3%) had clinical response. There was no significant difference of apoptotic index before and after neoadjuvant chemotherapy (5.47+1.38 vs 5.52+1.08 pg/mL). There was also no significant relationship between apoptosis index and clinical response (p=0.993). This study showed that apoptotic index fails to be neoadjuvant chemotherapy response predictor in triple negative breast cancer. Further research with larger samples is needed to confirm this result

Improved basic life support skills and patient transportation at ambulance drivers in Medan Tuntung and Medan Sunggal area to improve patient safety Yetty Machrina; Siregar, Kamal Basri; Nuraiza Meutia; Gema Nazri Yanni; Yunita Sari Pane
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

The technique of providing basic and quick life support (BHD) and transportation to patients with cardiac and pulmonary arrest can save a patient's life. An ambulance driver as one of the ambulance personnel should be equipped with the two forms of skills above. The aim of community service is to increase the capacity of ambulance drivers in terms of providing basic life support skills and patient transportation to improve patient safety. This training was held in September 2019, at the H. Adam Malik General Hospital Training Center Installation Medan, with 24 participants. The training is carried out with 2 methods, namely exposure to BHD theory and BHD skills training. The knowledge and skills of participants before and after the training were assessed. Pre and post assessment results were analyzed using paired t-test with a significance level of p <0.05 Ambulance drivers in the Medan Tuntung and Medan Sunggal area are mostly over 30 years old, with most working as ambulance drivers for more than 5 years. The most recent level of education is high school graduation or equivalent. The results of statistical analysis using paired t-test, obtained a significant difference in the knowledge of ambulance drivers about basic life support theory before and after training (p = 0.000). Likewise, ambulance driver skills in providing basic life support for adult patients, infants and children were significantly different before and after training (p = 0.000). Training in basic life support skills and patient transportation can increase the capacity of ambulance drivers in providing basic life support..

Profil ekspresi HER2 dan Ki67 pada berbagai kelompok usia penderita kanker payudara di RSUP H. Adam Malik Medan Santer dr; Kamal Basri Siregar; Suyatno dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 3 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introductions : Breast cancer is commonly found in old age. Many genes had been reported to be involved in the carcinogenesis of breast carcinoma, such as p53, Ki67, cathepsin D, and HER2. Some studies reported that HER2 overexpression associated with age. Ki67 levels are associated with poor disease free survival.The aim of this study was to determine the level of overexpression of HER2 and Ki67 in the various age groups of breast cancer patients in H. Adam Malik Hospital Medan.Methods: This study was a descriptive cross sectional study, by examining Ki67 by immunohistochemistry in 40 paraffin blocks of breast cancer patients who had diagnosed in HER2 by immunohistochemistry examination. Specific cut off point of Ki67 was 14%.Results: 40 female samples had been studied. The majority of respondents are 35-50 years age group (45%). HER2 (+) were 12 samples and HER2 (-) were 28 samples. HER2 (+) was found in the 51-65 year age group of 6 sample (50%). Over expression of Ki67 were found in 28 samples and low expression in 12 samples. Over expression of Ki67 in the age group >65 years were 3 samples (100%).Conclusion: Over expression of HER2 and Ki67 found more in older age groups, based on the number of samples in each age group.Keywords: age; HER2 expression; Ki67 expression

Clinicopathological Profile Of Her2 Positive (Non-Luminal) Breast Cancer Subtype At Haji Adam Malik General Hospital From 2020-2021 Natanael, Yosua; Siregar, Denny Rifsal; Siregar, Kamal Basri; Rohmawati, Lili
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 1 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i1.37533

Background: Breast cancer is one of the cancers with the highest prevalence in Indonesia. According to GLOBOCAN data for 2020, the number of breast cancer cases reached 68,858 (16.6%) cases out of a total of 396,914 new cancer cases in Indonesia. There are many factors that can trigger cancer with different clinical manifestations and subtypes from one event to another, so researchers are interested in researching the profile of breast cancer patients with the HER2 subtype at H. Adam Malik General Hospital in 2020-2021.Objective: In the present study, we aim to determine the clinicopathological profile of Her2 positive (non-luminal) breast cancer subtype patients at Haji Adam Malik General Hospital from 2020-2021.Methods: The method used in this study is descriptive quantitative with total sampling technique. The data samples was obtained from medical records of breast cancer patient with her2 positive (non-luminal) subtype which was then sorted according to the availability of characteristic needed for this study. Results: majority of breast cancer patients with her2 positive (non-luminal) subtype at H Adam Malik General Hospital in 2020-2021 was within the age group of > 50 years, with all married status. the BMI of the majority of patients (68.6%) was normal weight, all respondent admit there was no family history diagnosed with cancer (100%), majority tumor size (52,9%) is >5 cm, with most patients having cancer metastasized to 1-3 lymph nodes (54,9%), distant metastases only in 39,2% of the total sample observed, majority (35,3%) histopathological degree is in grade 1 and grade 3 , the histopathological classification of the majority (86,3%) was IDC type. Conclusion: Overall there is diversity of frequencies within the observed clinicopathological characteristics.

Assessment of Quality of Life in Advanced-Stage Lung Cancer Patients Using EORTC QLQ-C30 Questionnaire Ariantika, Ariantika; Lubis, Rahayu; Asfriyati, Asfriyati; Ashar, Taufik; Nurmaini, Nurmaini; Soeroso, Noni Novisari; Siregar, Kamal Basri; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.228-235

Introduction: Quality of life (QoL) is a multidomain concept that assesses a person through health status, functional status, and symptoms. The patient's QoL is greatly reduced due to the course of disease, severity of symptoms, and side effects of chemotherapy treatment. This study aimed to assess the QoL in advanced lung cancer patients using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30). Methods: This descriptive and observational study was conducted at the Pulmonary Polyclinic, Prof. Dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (USU) Hospital from February to July 2024, with a cross-sectional design using patient medical records and EORTC QLQ-C30 questionnaire. The EORTC QLQ-C30 questionnaire was analyzed with a score formula and categorized as good, moderate, and bad. The sample was 100 lung cancer patients using a purposive sampling technique according to the criteria. Results: The results showed that almost all QoL was in the moderate category (80%). The general health status was mostly in the moderate category (61.66%), the functional status was mostly in the good category (75.35%), and the symptoms were in the moderate category (35.65%). In the functional scale, the role domain had the lowest mean, 69.99 ± 29.43. In the symptoms scale, the pain domain had the highest mean, 52.66 ± 29.43. Conclusion: The overall QoL of lung cancer patients was in the moderate category, lower than the healthy population. It needs to be improved, especially in the role domain, by providing supportive-expressive group therapy.

Cancer-Related Visits to the Emergency Department: Trends and Patient Characteristics at Adam Malik General Hospital Medan Basri Siregar, Kamal; Rahayu, Yolanda; Suganda, Yongki; Andrea, Aze
Sumatera Medical Journal Vol. 6 No. 3 (2023): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v6i3.12830

Background: The prevalence of cancer cases globally is increasing rapidly, especially in emergency department (ED) visits. Usually, cancer patients come for acute signs and symptoms of a still undiagnosed malignancy, management of treatment-related side effects, co-morbidities, and palliative care. Objective: To identify the demographic characteristics of cancer patients, reasons for ED visits, and associated factors of oncologic patients. Methods: A prospective cross-sectional study was conducted from July 2022 - June 2023 at the ED of H. Adam Malik Hospital Medan with 392 oncologic patients. Data were collected using the Integrated System Application of Hospital (STARS) database. Results: The percentage of women (69%) was two times higher than men (31%), with 82% being 18- 64 years old. Breast was the most common location of malignancy for 21.4%, followed by gastrointestinal malignancy for 20.1%. The most common reason for ED visits was pain, followed by gastrointestinal symptoms. The ratio of patients who were discharged and hospitalized was 50:50, while the mortality rate was none. Conclusion: The most common primary diagnosis was breast malignancy in women and gastrointestinal malignancy in men. The majority of ED visits were for the management of treatment-related side effects and palliative care.

Improved basic life support skills and patient transportation at ambulance drivers in Medan Tuntung and Medan Sunggal area to improve patient safety Yetty Machrina; Siregar, Kamal Basri; Nuraiza Meutia; Gema Nazri Yanni; Yunita Sari Pane
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2019): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

The technique of providing basic and quick life support (BHD) and transportation to patients with cardiac and pulmonary arrest can save a patient's life. An ambulance driver as one of the ambulance personnel should be equipped with the two forms of skills above. The aim of community service is to increase the capacity of ambulance drivers in terms of providing basic life support skills and patient transportation to improve patient safety. This training was held in September 2019, at the H. Adam Malik General Hospital Training Center Installation Medan, with 24 participants. The training is carried out with 2 methods, namely exposure to BHD theory and BHD skills training. The knowledge and skills of participants before and after the training were assessed. Pre and post assessment results were analyzed using paired t-test with a significance level of p <0.05 Ambulance drivers in the Medan Tuntung and Medan Sunggal area are mostly over 30 years old, with most working as ambulance drivers for more than 5 years. The most recent level of education is high school graduation or equivalent. The results of statistical analysis using paired t-test, obtained a significant difference in the knowledge of ambulance drivers about basic life support theory before and after training (p = 0.000). Likewise, ambulance driver skills in providing basic life support for adult patients, infants and children were significantly different before and after training (p = 0.000). Training in basic life support skills and patient transportation can increase the capacity of ambulance drivers in providing basic life support..

Frequency Distribution of Oncology Patients Who Come to Emergency Department at H. Adam Malik Hospital, Medan Basri Siregar, Kamal; Manik, David Restu; Hakim, Luqmanul; Gultom, Habib Solihin; Naqib bin Md Ghazali, Muhammad
Sumatera Medical Journal Vol. 7 No. 3 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i3.13698

Background: A multidisciplinary approach is needed to comprehensively evaluate cancer patient’s condition and understanding patient demographic characteristics can improve health care by adapting to each patient's needs. Objective: The aim of this study was to explore about frequency distribution of oncolohy patients. Methods: This research is a descriptive observational study with a cross-sectional study design conducted at the Haji Adam Malik General Hospital in Medan on oncology patients who met the inclusion criteria. Data with a numerical measuring scale will be presented in mean+standard deviation (SD) and data with a categorical measuring scale will be presented in frequencies and percentages. Results: The results showed that majority of patients were in 46–59 year age group as much as 32 patients (37.2%) and 58 patients (67.4%) were female. The highest level of education was found in 26 patients (30.2%) as bachelor, and 45 patients (52.3%) lived in Medan City. Most patients came to be treated at the surgical installation as many as 50 patients (25.6%). Conclusion: The research results found that majority of patients are in the age group 46-59 years, female, bachelor, domicile in Medan and are treated in surgical installation.

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