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All Journal Al-MIKRAJ: Jurnal studi Islam dan Humaniora Molekul: Jurnal Ilmiah Kimia
Nurjannah, Sofia
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Social Sciences

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LC-MS Based Metabolite Profiling of Ethanol Extract From the Sungkai (Peronema canescens Jack) and In Silico Prediction of Antidiabetic Activity With α-Glucosidase Latief, Madyawati; Arum, Dewi; Nurjannah, Sofia; Tarigan, Indra Lasmana; Khatib, Alfi; Yusnaidar, Yusnaidar
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.8806

Abstract

Sungkai (Peronema canescens Jack) is a medicinal plant in the Verbenaceae family that is known to have antidiabetic activity. The secondary metabolite content found in sungkai leaves is in the form of alkaloids, flavonoids, triterpenoids, steroids, phenolics, and saponins. This research aimed to identify the biological activity of compounds in sungkai plants as antidiabetic agents using α-glucosidase inhibitors in silico. Sungkai leaf extract with ethanol solvent was identified using a Liquid Chromatography Mass Spectrometer (LC-MS/MS). There are 15 compounds resulting from LC-MS/MS analysis which will then predict antidiabetic activity using molecular docking. Molecular docking was carried out using AutoDock Tools software and visualized with Discovery Studio. The highest scoring result obtained from the molecular docking test was the compound C13H23N6S with a free bond energy result of -7.31 and an inhibition constant value of 4.41 μM, which binds three hydrogen bonds in GLU 78, ALA 75, and GLU 198. Keywords: In sillico, metabolite profilling, Peronema canescens
Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Rimbang (Solanum Torvum Swartz) terhadap Bakteri Propionibacterium Acnes Nurjannah, Sofia; Kusumastuti, Melati Yulia; Safriana, Safriana; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 2 (2025): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i2.6849

Abstract

The skin is the outermost part of the body that limits it from the human environment. Damage to the skin glands can cause skin disorders, one of which is acne. The bacteria that cause acne are Propionibacterium acnes bacteria. Antibiotics are needed to inhibit bacterial growth, but improper use can cause side effects. The purpose of this study was to explore the antibacterial activity of the ethanol extract gel preparation of rimbang leaves (solanum torvum swartz) against propionibacterium acnes bacteria. This research method is with an experimental quantitative approach. The stages of the study include screening of powdered simplicia and ethanol extract, Formulation of gel preparations without test materials and ethanol extract of rimbang leaves (EEDR) 10%, 20%, 30%, Evaluation tests of the preparations include: organoleptic, homogeneity, stability, adhesion, spreadability, viscosity, pH, irritation, and preference. Then the antibacterial activity test uses the well method. The results showed that the screening results on powdered simplicia and ethanol extract met the physical quality requirements of secondary metabolite compounds. The results of the antibacterial activity of EEDR 30% bacterial inhibition diameter of 14.33 ± 8.72. EEDR 20% produced a bacterial inhibition diameter of 12 ± 11.4. EEDR 10% produced a bacterial inhibition diameter of 10.67 ± 8.70. While the blank produced a bacterial inhibition diameter of 6.33 ± 3.26. From this study it can be concluded that the preparation of ethanol extract gel of rimbang leaves has inhibitory activity against Propionibacterium acnes bacteria.
Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Rimbang (Solanum Torvum Swartz) terhadap Bakteri Propionibacterium Acnes: Antibacterial Activity Test of Ethanol Extract Gel Preparation of Rimbang Leaves (Solanum Torvum Swartz) against Propionibacterium Acnes Bacteria Nurjannah, Sofia; Kusumastuti, Melati Yulia; Safriana, Safriana; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 2 (2025): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i2.6849

Abstract

The skin is the outermost part of the body that limits it from the human environment. Damage to the skin glands can cause skin disorders, one of which is acne. The bacteria that cause acne are Propionibacterium acnes bacteria. Antibiotics are needed to inhibit bacterial growth, but improper use can cause side effects. The purpose of this study was to explore the antibacterial activity of the ethanol extract gel preparation of rimbang leaves (solanum torvum swartz) against propionibacterium acnes bacteria. This research method is with an experimental quantitative approach. The stages of the study include screening of powdered simplicia and ethanol extract, Formulation of gel preparations without test materials and ethanol extract of rimbang leaves (EEDR) 10%, 20%, 30%, Evaluation tests of the preparations include: organoleptic, homogeneity, stability, adhesion, spreadability, viscosity, pH, irritation, and preference. Then the antibacterial activity test uses the well method. The results showed that the screening results on powdered simplicia and ethanol extract met the physical quality requirements of secondary metabolite compounds. The results of the antibacterial activity of EEDR 30% bacterial inhibition diameter of 14.33 ± 8.72. EEDR 20% produced a bacterial inhibition diameter of 12 ± 11.4. EEDR 10% produced a bacterial inhibition diameter of 10.67 ± 8.70. While the blank produced a bacterial inhibition diameter of 6.33 ± 3.26. From this study it can be concluded that the preparation of ethanol extract gel of rimbang leaves has inhibitory activity against Propionibacterium acnes bacteria.
Co-Authors Alfi Khatib, Alfi Arum, Dewi Indra Lasmana Tarigan Kusumastuti, Melati Yulia Madyawati Latief Safriana Safriana Tanjung, Siti Aisyah Yusnaidar, Yusnaidar