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FORMULASI SABUN CAIR ANTISEPTIK SARI AIR KULIT BUAH PISANG AMBON (MUSA PARADISIACA VAR SEPIENTUM L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Ramadani, Muhammad; Gunawan, Muhammad; Fitriani, Enny; Kusumastuti, Melati Yulia
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1770

Cleanliness of the skin, hands and body is a state of being free of dirt, dust and microorganisms that can cause infection. The existence of these microorganisms can be overcome by using soap containing chemical compounds that have antibacterial activity. In the market there are many circulating antiseptic soaps containing synthetic antibacterials, but they often cause side effects, so it is necessary to make soaps containing natural antibacterials, for example, Ambon banana peel contains polyphenolic compounds and saponins have antibacterial activity. The study conducted a phytochemical screening of Ambon banana peels, made liquid soap containing water extract of Ambon banana peels as a cleanser and antibacterial and carried out antibacterial activity tests. Research stages: phytochemical screening of Ambon banana peel and water extract, liquid soap formulation containing 10%, 20% and 30% Ambon banana peel water extract (SKPA), evaluation of liquid soap including: stability, foam height, pH, irritation and preference test . Antibacterial activity test against Staphylococcus aureus, Escherichia coli and bacteria from volunteer hand washing water specimens. The results showed that the water extract from Ambon banana peel contains alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides, which can be formulated into liquid soap (SKPA) fulfilling the physical quality requirements. SKPA 30% liquid soap is the best because it is very liked by researchers, has strong antibacterial activity, diameter of inhibition against Staphylococcus aureus (17.23 ± 0.66) mm, and Escherichia coli (15.83 ± 0.66) mm. The total plate number for volunteer hand washing specimens, 10% SKPA resulted in a reduction of bacterial colonies of 49.78%, 30% SKPA obtained the greatest reduction in bacteria, namely 82.79, almost the same as Dettol liquid soap. What is circulating in the market is 83.02%.

Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.

Perbandingan Aktivitas Antibakteri Dekokta dan Infusa Daun Iler (Plectranthus Amboinicus (Lour.) Spreng.) terhadap Bakteri Staphylococcus Aureus dan Escherichia Coli Siregar, Rizki Marwiyah; Kusumastuti, Melati Yulia; Gunawan, Muhammad
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6142

Infectious diseases are one of the most common types of diseases suffered by people in developing countries including Indonesia. Bacteria are one of the main causes of infectious diseases and to treat bacterial infections can be done by administering antibacterial drugs. The purpose of this study was to determine the antibacterial activity of decoction and infusion from iler leaves (Plectranthus amboinicus (Lour.) Spreng.) Against Staphylococcus aureus and Escherichia coli bacteria. This research method uses quantitative and experimental nature by making infusion and decoction from iler leaves (Plectranthus amboinicus (Lour.) Spreng.) Against Staphylococcus aureus and Escherichia coli bacteria. This research was conducted from June to August 2024. The results of the study through phytochemical screening tests showed the same group of chemical compounds in the simplicia, decoction and infusion of iler leaves containing secondary metabolite compounds including flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Then the antibacterial activity of iler leaves against Staphylococcus aureus and Escherichia coli bacteria with various concentrations of 10%, 20% and 30% in decoction and infusion gave the strongest results at a concentration of 30%, namely in decoction with a concentration of 30% with an average inhibition zone of 12 mm, and infusion of 15.3 mm. While the antibacterial activity of Escherichia coli in decoction with a concentration of 30% with an average inhibition zone of 10.8 mm and in infusion with a concentration of 30% with an average inhibition zone of 11.9 mm. So, the test results show that infusion has higher antibacterial activity than decoction. And in the inhibition test on both bacteria, it inhibits Staphylococcus aureus bacteria faster than Escherichia coli.

Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Rimbang (Solanum Torvum Swartz) terhadap Bakteri Propionibacterium Acnes Nurjannah, Sofia; Kusumastuti, Melati Yulia; Safriana, Safriana; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 2 (2025): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i2.6849

The skin is the outermost part of the body that limits it from the human environment. Damage to the skin glands can cause skin disorders, one of which is acne. The bacteria that cause acne are Propionibacterium acnes bacteria. Antibiotics are needed to inhibit bacterial growth, but improper use can cause side effects. The purpose of this study was to explore the antibacterial activity of the ethanol extract gel preparation of rimbang leaves (solanum torvum swartz) against propionibacterium acnes bacteria. This research method is with an experimental quantitative approach. The stages of the study include screening of powdered simplicia and ethanol extract, Formulation of gel preparations without test materials and ethanol extract of rimbang leaves (EEDR) 10%, 20%, 30%, Evaluation tests of the preparations include: organoleptic, homogeneity, stability, adhesion, spreadability, viscosity, pH, irritation, and preference. Then the antibacterial activity test uses the well method. The results showed that the screening results on powdered simplicia and ethanol extract met the physical quality requirements of secondary metabolite compounds. The results of the antibacterial activity of EEDR 30% bacterial inhibition diameter of 14.33 ± 8.72. EEDR 20% produced a bacterial inhibition diameter of 12 ± 11.4. EEDR 10% produced a bacterial inhibition diameter of 10.67 ± 8.70. While the blank produced a bacterial inhibition diameter of 6.33 ± 3.26. From this study it can be concluded that the preparation of ethanol extract gel of rimbang leaves has inhibitory activity against Propionibacterium acnes bacteria.

Perbandingan Aktivitas Antibakteri Dekokta dan Infusa Daun Iler (Plectranthus Amboinicus (Lour.) Spreng.) terhadap Bakteri Staphylococcus Aureus dan Escherichia Coli Siregar, Rizki Marwiyah; Kusumastuti, Melati Yulia; Gunawan, Muhammad
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6142

Infectious diseases are one of the most common types of diseases suffered by people in developing countries including Indonesia. Bacteria are one of the main causes of infectious diseases and to treat bacterial infections can be done by administering antibacterial drugs. The purpose of this study was to determine the antibacterial activity of decoction and infusion from iler leaves (Plectranthus amboinicus (Lour.) Spreng.) Against Staphylococcus aureus and Escherichia coli bacteria. This research method uses quantitative and experimental nature by making infusion and decoction from iler leaves (Plectranthus amboinicus (Lour.) Spreng.) Against Staphylococcus aureus and Escherichia coli bacteria. This research was conducted from June to August 2024. The results of the study through phytochemical screening tests showed the same group of chemical compounds in the simplicia, decoction and infusion of iler leaves containing secondary metabolite compounds including flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Then the antibacterial activity of iler leaves against Staphylococcus aureus and Escherichia coli bacteria with various concentrations of 10%, 20% and 30% in decoction and infusion gave the strongest results at a concentration of 30%, namely in decoction with a concentration of 30% with an average inhibition zone of 12 mm, and infusion of 15.3 mm. While the antibacterial activity of Escherichia coli in decoction with a concentration of 30% with an average inhibition zone of 10.8 mm and in infusion with a concentration of 30% with an average inhibition zone of 11.9 mm. So, the test results show that infusion has higher antibacterial activity than decoction. And in the inhibition test on both bacteria, it inhibits Staphylococcus aureus bacteria faster than Escherichia coli.

Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Rimbang (Solanum Torvum Swartz) terhadap Bakteri Propionibacterium Acnes: Antibacterial Activity Test of Ethanol Extract Gel Preparation of Rimbang Leaves (Solanum Torvum Swartz) against Propionibacterium Acnes Bacteria Nurjannah, Sofia; Kusumastuti, Melati Yulia; Safriana, Safriana; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora Vol. 5 No. 2 (2025): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i2.6849

The skin is the outermost part of the body that limits it from the human environment. Damage to the skin glands can cause skin disorders, one of which is acne. The bacteria that cause acne are Propionibacterium acnes bacteria. Antibiotics are needed to inhibit bacterial growth, but improper use can cause side effects. The purpose of this study was to explore the antibacterial activity of the ethanol extract gel preparation of rimbang leaves (solanum torvum swartz) against propionibacterium acnes bacteria. This research method is with an experimental quantitative approach. The stages of the study include screening of powdered simplicia and ethanol extract, Formulation of gel preparations without test materials and ethanol extract of rimbang leaves (EEDR) 10%, 20%, 30%, Evaluation tests of the preparations include: organoleptic, homogeneity, stability, adhesion, spreadability, viscosity, pH, irritation, and preference. Then the antibacterial activity test uses the well method. The results showed that the screening results on powdered simplicia and ethanol extract met the physical quality requirements of secondary metabolite compounds. The results of the antibacterial activity of EEDR 30% bacterial inhibition diameter of 14.33 ± 8.72. EEDR 20% produced a bacterial inhibition diameter of 12 ± 11.4. EEDR 10% produced a bacterial inhibition diameter of 10.67 ± 8.70. While the blank produced a bacterial inhibition diameter of 6.33 ± 3.26. From this study it can be concluded that the preparation of ethanol extract gel of rimbang leaves has inhibitory activity against Propionibacterium acnes bacteria.

Controlled release kinetics of furosemide from chitosan matrix tablets with hydroxypropyl methylcellulose phthalate coated Samran, Samran; Suprianto, Suprianto; Sumardi, Sumardi; Ritonga, Ahmad Hafizullah; Kusumastuti, Melati Yulia
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28097

Sustained-release dosage forms were critical in drug delivery, ensuring controlled and prolonged release for optimal therapeutic outcomes. Chitosan (CH) has become pivotal in sustained-release tablet formulation due to its biocompatibility and mucoadhesive properties. This study aims to explore the release kinetics of furosemide (FS) from CH matrix tablets in a concurrent medium. The formulation involves a core tablet and coated tablet, with CH matrix as a binder and Hydroxypropyl Methyl Cellulose Phthalate (HPMCP) as a film-coated for the core tablet, and both are made using the wet granulation method. Assessment parameters include tablet hardness, disintegration, and FS release profiles across various media, analyzed using spectrophotometric methods to comprehend drug release kinetics with multiple models such as zero-order, first-order, Higuchi, and Korsmeyer-Peppas employed. In the press-coated tablet comprising core tablet CH as matrix uncoated with 20 mg CH per tablet core, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h, which displayed first-order release kinetics within 2-6 h and 6-16 h in concurrent media of pH 5.8 and 7.4. Notably, a zero-order release pattern emerged in the pH 1.2 medium within 0-2 h. Press-coated tablets incorporating CH matrix with HPCMP coated (CH-HPCMP), also containing 20 mg CH per tablet, exhibited diverse drug release kinetics. These tablets showed Korsmeyer-Peppas, zero-order, and first-order kinetics in pH 1.2, 5.8, and 7.4, respectively. The study suggests that a Press-coated tablet incorporating CH-HPMCP is suitable as the candidate for sustained-release formulations. The observed versatility in release kinetics across varying pH environments underscores the potential adaptability of these formulations in addressing diverse therapeutic needs.

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