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Antidiabetic Effectiveness Test of Ethanol Extract of Brown Leaves (Theobroma Cacao L.) Against Mice (Mus Musculus) Gunawan, Muhammad; Safriana; Tanjung, Siti Aisyah; Andilala
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.775

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. DM sufferers are increasing from year to year, accompanied by increasing costs of therapy, therefore, as an alternative to controlling blood glucose levels, use natural ingredients such as cocoa leaves. The aim of this research was to determine the effectiveness of ethanol extract of cocoa leaves (Theobroma cacao L.) in reducing blood glucose levels in mice that had been induced by Aloxan. The research method used was experimental research. The research stages were sample collection, sample identification, making simpilicia, examining the characteristics of simpilicia, making extracts using maceration using 96% ethanol solvent, and testing the antidiabetic effect of EEDC in mice induced by alloxan at a dose of 175 mg/kg. bb intraperitoneally. Diabetic mice were divided into 5 groups, each group consisting of 5 mice that were given the test material 50 mg/KgBB of ethanol extract of brown leaves; 100 mg/KgBB; and 200 mg/KgBB, Metformin 65 mg/KgBB, and CMC 0.5%. Next, blood glucose levels were measured on days 3, 6, 9, 12, and 15, the percentage reduction in blood glucose levels was calculated, then the data was analyzed using the One-Way ANOVA method and Duncan's test, to see real differences between treatments. The research results showed that simplicia, the ethanol extract of brown leaves contains flavonoids, alkaloids, tannins, steroids/triterpenoids, saponins and glycosides. Cocoa leaf ethanol extract has effectiveness in lowering glucose levels, at the 5th and 6th hours it shows good effectiveness at a dose of 200 mg/KgBW of (72.16 ± 0.1.51)% and (82.80 ± 0.73 )%, not significantly different from metfromin 65 mg/KgBB of (74.45 ± 1.51)% and (83.29 ± 1.01).

Formulation and Effectiveness of Herbal Hair Dye from Ethanol Extract of Banyan Bark (Ficus benjamina L) Safitri, Dewi; Tanjung, Siti Aisyah; Fitriani, Enny; Fatimah, Cut
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17656

The banyan plant (Ficus benjamina Linn.) is one of the plants that has benefit as a traditional medicine. Almost all parts of the plant have efficacy as a source of medicine and furniture or decoration. However, banyan bark is often considered waste. Based on the results of phytochemical screening that has been carried out, banyan bark contains chemical compounds tannins, saponins, flavonoids, alkaloids and glycosides. Flavonoids are a group of flavanols derived from benzene compounds that can be used as basic compounds of natural dyes. Therefore, the aim of this research is to try to make herbal hair dye using banyan bark (Ficus benjamina Linn.) as a natural dyeing ingredient. The research method used is experimental with 80% ethanol solvent. The formulation of herbal hair dye consists of extract of banyan bark (Ficus benjamina Linn), Piragalol, Xanthan gum, Methyl parabens, and BHT with concentration of 4%, 6% and 8%, respectively. Tests on the preparations made include organoleptic tests, homogeneity tests, viscosity tests, pH tests, stability tests, irritation tests, color stability tests produced, color stability tests against washing, color stability tests against sunlight and preference tests. The formulation of herbal hair dyes uses ethanol extract of banyan bark which can give color to gray hair with concentrations of ethanol extract of banyan bark 4%, 6% and 8%, Pyroganol 1%, Xanthan gum 1%, Methyl paraben and BHT. Banyan bark ethanol extract (Ficus benjamina Linn.) can be used in herbal hair dye by producing a blonde to dark brown color in gray hair. The best dye is obtained from the formula with concentration of 8% which consists of ethanol extract of banyan bark (EKBB) which produces a dark brown color, the pH of the preparation in the range of 5.8 – 6.1, the viscosity in the range of 2800 – 4800 cps, and the preparation is stable in several washes and exposure to direct sunlight and does not cause irritation reactions to the skin.

Uji Most Probable Number (MPN) Bakteri Coliform Pada Jamu Yang Beredar di Pasaran Kusumastuti, Yulia; Tanjung, Siti Aisyah; Fatimah, Cut; Ayi, Alicia
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6140

Herbal Medicine is one of the traditional medicines used since the time of the ancestors until now with ingredients that have not been standardized. jamu has a myriad of benefits for the human body, one of which can maintain body health, prevent disease, maintain fitness and beauty. jamu has two types circulating in the market, namely jamu gendong and jamu kemasan. Processing of jamu gendong which is still done in a simple way with makeshift tools is very likely to cause bacterial contamination. Rich biological resources, especially medicinal plants, can be found in Indonesia. According to research, 90% of Asia's medicinal plants are estimated to be found in Indonesia, with 25% of them-about 7,500 plant species-having been proven effective. In the process of making herbal medicine, it is very important to look at its hygienity, this is because herbal medicine is very easily contaminated by bacteria such as Coliform bacteria, which are indicators of bacterial contamination in general. in this test carried out by the MPN method, the authors are interested in examining the Coliform bacteria mpn test on herbal medicine circulating in the sudirejo village, Medan city. This test sample was carried out using a simple random method on jamu gendong and jamu packaging located in sudirejo Medan. in testing bacterial contamination using Most Probable Number (MPN) with a 3:3:3 tube series with Lactose Broth (BGLB) media and a complete test using Eosin Methylen Blue Agar (EMBA) media, performing gram dye painting and observing microscopic colonies. The results in this study showed that all samples of jamu gendong and packaged jamu (K3) found in the Sudirejo Medan area were contaminated with Coliform bacteria, while the sample of packaged jamu (K6) was not contaminated with Coliform bacteria.

Testing the Antihyperurisemic Effectiveness of the Ethanol Extract of Henna Leaf (Lawsonia Mermis L.) on Induced Male Mice (Mus Musculus) with Chicken Liver and Potassium Bromate Muhammad Gunawan; Tanjung, Siti Aisyah; Safriana, Safriana; Fitriani, Enny
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.1126

Hyperuricemia is a condition that is marked by an increase in blood pressure in the blood that exceeds the normal level, ie above 7.0 mg/dl in the patient and above 6.0 mg/dl in women. It is generally intended to address hyperuricemia in the use of synthesized drugs that can give rise to the effect of retinal pain, vomiting, diarrhea, damage to the liver, nephritis in the brain and hypertheritivity. By therefore developing alternative treatments using plant medicine as well as parsley nails (Lawson mermis L.). This research is aimed at identifying extracurricular nephew nails (EEDPK) against decreasing levels of pregnancy in males who are induced by liver cancer and galleria. This research uses experimental methods with gathering and processing materials, identification of growth, making implicit, making extracts, determining water levels, preparing animal trials, and testing EEDPK effects. Animals used 24 eggs were divided into 6 groups of tests, group divisions included normal groups, induction, comparison, and EEDPK in 3 doses of 150 mg/kg body weight, 300 mg/kg body weight, and EEDPK 600 mg/kg body weight version 25 with 95% confidence level. The results of the EEDPK water level assessment were 3.33%. The results of the efficacy of hyperuricides will be shown that EEDPK provides the effect of the most effective extracts as antihyperuricemia is 300 mg/kgBB compared to other groups of extract.

Formulasi Hair Tonic Ekstrak Etanol Kulit Buah Pepaya (Carica Papaya L.) dan Uji Efektivitas Pertumbuhan Rambut pada Marmut Jantan (Cavia porcellus) Candani, Mella; Gunawan, Muhammad; Tanjung, Siti Aisyah; Bagas, Muhammad
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6198

Hair for humans has an important role, in addition to protecting the skin from adverse environments, hair also plays an important role in a person's appearance. Losing a lot of hair due to hair loss can cause a lack of self-confidence, disappointment, and frustration, so it must be addressed immediately so as not to worsen the condition that can cause baldness. This study aims to determine whether there is a content of secondary metabolite compounds in fresh herbal medicine, herbal medicine powder and ethanol extract of papaya fruit skin; ethanol extract of papaya fruit skin (Carica papaya L.) can be formulated in the form of hair tonic preparations; whether the difference in concentration of ethanol extract of papaya fruit skin (Carica papaya L.) provides different activities in triggering hair growth in guinea pigs. This research method uses a quantitative approach and is experimental with independent variables, namely papaya fruit skin, herbal medicine, and ethanol extract of papaya fruit skin with concentrations of 10%, 20%, 30%. Research stages: phytochemical screening of fresh papaya fruit peel, powdered simplicia and ethanol extract, hair tonic formulation containing ethanol extract of papaya fruit peel 10%, 20% and 30%, hair tonic evaluation includes: organoleptic, viscosity, stability, pH, irritation, and preference test. And hair growth activity test on male guinea pigs. The results showed that the ethanol extract of papaya fruit peel contains alkaloids, flavonoids, saponins, steroids, and glycosides, can be formulated into hair tonic (EEKP) that meets physical quality requirements. Hair tonic EEKP 30% is the best because it has high hair growth activity, which is an average of 16.375 mm where this EEKP 30% hair tonic has almost the same hair growth activity as the positive control, which is an average of 16.782 mm.

Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Sawo (Manilkara Zapota L.) dan Uji Efektivitas Sebagai Pelembab Kulit Hamna, Aulia; Safriana, Safriana; Fatimah, Cut; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6444

The skin is the largest organ of the body that is often exposed to the environment so it is prone to dryness and health problems. Skin moisturizing cosmetic preparations often contain synthetic chemicals so that their use often causes side effects, in the form of skin disorders so that it is necessary to find alternative natural ingredients that can provide safer skin moisture, for example ripe sapodilla fruit skin, which has been empirically proven to moisturize the skin. This study aims to test the chemical content, formulate ethanol extract of ripe sapodilla fruit skin in the form of a cream, and evaluate the effectiveness and safety of the cream as a skin moisturizer. The method used in this study is an experimental method with a quantitative approach, starting with the manufacture of simplicia and its characteristics test, manufacture of ethanol extract of ripe sapodilla fruit skin, phytochemical screening test, making cream preparations with ethanol extract concentrations of ripe sapodilla fruit skin 5%, 10%, and 15% followed by physical quality tests including organoleptic and stability tests, homogeneity tests, emulsion type tests, pH tests, spreadability tests, adhesion tests, irritation tests on volunteers, preference tests, and effectiveness tests of the preparation as a skin moisturizer. The results of the study showed that phytochemical screening of fresh ripe sapodilla fruit skin, crude drugs, and its ethanol extract showed the presence of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. Ethanol extract of ripe sapodilla fruit skin can be formulated into a skin moisturizer cream preparation with stable color, aroma, and shape within 4 weeks, the pH of the preparation is in accordance with the skin pH of 4.5-6.5, does not irritate and has effectiveness as a skin moisturizer, increases water content in the skin by 40.04 ± 3.47%. and reduces oil content by 24.46 ± 2.20%.

Formulasi Sediaan Masker Gel Ekstrak Etanol dari Daun Kembang Sepatu (Hibiscus Rosa-Sinensis L.) Sebagai Pelembab Kulit Sari, Secillia May; Tanjung, Siti Aisyah; Gunawan, Muhammad; Safriana, Safriana
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 01 (2024): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i01.6503

Skin often dries out due to evaporation and loss of moisture due to dry air, hot weather, aging, skin diseases, etc., so that the skin surface becomes scaly and wrinkled. Moisturizers consist of ingredients that can form and change the texture of dry and rough skin and reduce water evaporation from the skin. The purpose of this study was to analyze the formulation of a gel mask preparation of ethanol extract from hibiscus leaves (Hibiscus Rosa-Sinensis L.) as a skin moisturizer. This study was conducted using an experimental method using hibiscus leaves (Hibiscus rosa-sinensis L.) as a test material obtained by maceration using 80% ethanol solvent which had previously been tested for phytochemical screening and characterization of simplicia. The stages of this study include: making hibiscus leaf extract, making gel mask preparations, organoleptic tests, homogeneity tests, stability tests, viscosity tests, pH tests, spreadability tests, drying time tests, irritation tests, preference tests and skin moisturizer effectiveness tests. Phytochemical screening results showed that hibiscus leaves contain alkaloids, flavonoids, tannins, saponins, steroids and glycosides. Preparations with concentrations of 5%, 10%, 15% produced a homogeneous and stable gel mask from the first day to the 4th week, the pH of the preparation ranged from 6.30-6.56, the viscosity test produced 4.116-5.067, the spreadability test 6.2-6.7 cm, the dry time preparation test 20-22 minutes, the irritation test on volunteers showed no irritation and itching, the preference test value produced by the panelists liked the preparation from a concentration of 15% in terms of color, aroma and shape, and the effectiveness test as a skin moisturizer for water content taken from the highest concentration of 15% obtained an average result of 32.97 ± 2.93%, and for a decrease in oil content obtained 36.71 ± 6.89%.

INOVASI SEDIAAN SABUN PADAT TRANSPARAN DENGAN EKSTRAK ETANOL BUAH RIMBANG (Solanum torvum Swartz) SEBAGAI ANTISEPTIK Aulia, Syafitri; Safriana; Andilala; Tanjung, Siti Aisyah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 2 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i2.8098

Di pasaran banyak beredar sabun antiseptik mengandung antibakteri sintetis, namun sering menimbulkan efek samping, maka perlu dibuat sabun mengandung antiseptik alami contohnya buah rimbang yang mengandung senyawa metabolit sekunder dan mempunyai aktivitas antibakteri. Tujuan dari penelitian ini adalah untuk membuat formulasi sabun padat transparan sebagai antiseptik dari ekstrak etanol buah rimbang. Formulasi sabun padat transparan tanpa bahan uji (Blanko) dan ekstrak etanol buah rimbang konsentrasi 1,5%, 2% dan 2,5% dilakukan uji evaluasi mutu pada sediaan. Kemudian dilakukan uji efektivitas pada ekstrak etanol buah rimbang dan sediaan sabun padat transparan. Hasil uji skrining fitokimia pada simplisia dan ekstrak etanol buah rimbang memenuhi syarat mutu fisik pada senyawa metabolit sekunder. Hasil aktivitas antibakteri konsentrasi 2,5% diameter hambatan terhadap Staphylococcus aureus 19,47 ± 0,85 menunjukkan diameter hambatan sangat kuat. Angka lempeng total terhadap spesimen cuci tangan sukarelawan, EEBR 1,5% telah terjadi pengurangan koloni bakteri sebesar 73,32%, EEBR 2,5% diperoleh pengurangan bakteri paling besar yaitu 98,51%, hampir sama dengan sabun padat yang beredar di pasaran yaitu 98,75%. Dari penelitian ini dapat disimpulkan bahwa sediaan sabun padat transparan ekstrak etanol buah rimbang sebagai antiseptik memenuhi syarat dalam pembuatan sabun mandi.

Formulation and Effectiveness of Herbal Hair Dye from Ethanol Extract of Banyan Bark (Ficus benjamina L) Safitri, Dewi; Tanjung, Siti Aisyah; Fitriani, Enny; Fatimah, Cut
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.17656

The banyan plant (Ficus benjamina Linn.) is one of the plants that has benefit as a traditional medicine. Almost all parts of the plant have efficacy as a source of medicine and furniture or decoration. However, banyan bark is often considered waste. Based on the results of phytochemical screening that has been carried out, banyan bark contains chemical compounds tannins, saponins, flavonoids, alkaloids and glycosides. Flavonoids are a group of flavanols derived from benzene compounds that can be used as basic compounds of natural dyes. Therefore, the aim of this research is to try to make herbal hair dye using banyan bark (Ficus benjamina Linn.) as a natural dyeing ingredient. The research method used is experimental with 80% ethanol solvent. The formulation of herbal hair dye consists of extract of banyan bark (Ficus benjamina Linn), Piragalol, Xanthan gum, Methyl parabens, and BHT with concentration of 4%, 6% and 8%, respectively. Tests on the preparations made include organoleptic tests, homogeneity tests, viscosity tests, pH tests, stability tests, irritation tests, color stability tests produced, color stability tests against washing, color stability tests against sunlight and preference tests. The formulation of herbal hair dyes uses ethanol extract of banyan bark which can give color to gray hair with concentrations of ethanol extract of banyan bark 4%, 6% and 8%, Pyroganol 1%, Xanthan gum 1%, Methyl paraben and BHT. Banyan bark ethanol extract (Ficus benjamina Linn.) can be used in herbal hair dye by producing a blonde to dark brown color in gray hair. The best dye is obtained from the formula with concentration of 8% which consists of ethanol extract of banyan bark (EKBB) which produces a dark brown color, the pH of the preparation in the range of 5.8 – 6.1, the viscosity in the range of 2800 – 4800 cps, and the preparation is stable in several washes and exposure to direct sunlight and does not cause irritation reactions to the skin.

Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Daun Rimbang (Solanum Torvum Swartz) terhadap Bakteri Propionibacterium Acnes Nurjannah, Sofia; Kusumastuti, Melati Yulia; Safriana, Safriana; Tanjung, Siti Aisyah
AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584) Vol 5 No 2 (2025): Al-Mikraj, Jurnal Studi Islam dan Humaniora
Publisher : Pascasarjana Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/almikraj.v5i2.6849

The skin is the outermost part of the body that limits it from the human environment. Damage to the skin glands can cause skin disorders, one of which is acne. The bacteria that cause acne are Propionibacterium acnes bacteria. Antibiotics are needed to inhibit bacterial growth, but improper use can cause side effects. The purpose of this study was to explore the antibacterial activity of the ethanol extract gel preparation of rimbang leaves (solanum torvum swartz) against propionibacterium acnes bacteria. This research method is with an experimental quantitative approach. The stages of the study include screening of powdered simplicia and ethanol extract, Formulation of gel preparations without test materials and ethanol extract of rimbang leaves (EEDR) 10%, 20%, 30%, Evaluation tests of the preparations include: organoleptic, homogeneity, stability, adhesion, spreadability, viscosity, pH, irritation, and preference. Then the antibacterial activity test uses the well method. The results showed that the screening results on powdered simplicia and ethanol extract met the physical quality requirements of secondary metabolite compounds. The results of the antibacterial activity of EEDR 30% bacterial inhibition diameter of 14.33 ± 8.72. EEDR 20% produced a bacterial inhibition diameter of 12 ± 11.4. EEDR 10% produced a bacterial inhibition diameter of 10.67 ± 8.70. While the blank produced a bacterial inhibition diameter of 6.33 ± 3.26. From this study it can be concluded that the preparation of ethanol extract gel of rimbang leaves has inhibitory activity against Propionibacterium acnes bacteria.

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