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All Journal Jurnal Kedokteran Ibnu Nafis Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Veronica, Raja Merlinda
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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GANGGUAN SISTEM ORGAN PADA PASIEN DENGAN EXPANDED DENGUE SYNDROME: ORGAN SYSTEM DISORDERS IN PATIENTS WITH EXPANDED DENGUE SYNDROME Veronica, Raja Merlinda; Agustiawan; Zulfikar, Deza Harati; Kaonang, Mahardika Putri; Syahadatina
Jurnal Kedokteran Ibnu Nafis Vol. 13 No. 2 (2024): Desember 2024
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v13i2.682

Abstract

Dengue merupakan salah satu penyakit yang ditularkan oleh nyamuk Aedes dan penyebab utama penyakit virus yang ditularkan melalui arthropoda. Infeksi dengue dapat bermanifestasi sebagai demam dengue, demam berdarah dengue, dan syok dengue. Expanded dengue syndrome (EDS) merupakan terminologi yang dikembangkan dalam pedoman WHO tahun 2012. Manifestasi yang tidak biasa ini seringkali dikaitkan dengan koinfeksi, komorbiditas, atau komplikasi syok yang berkepanjangan dan dapat dikaitkan dengan EDS. Manifestasi yang tidak biasa mungkin tidak dilaporkan atau tidak dikenali atau tidak terkait dengan demam berdarah. Namun, penilaian klinis yang tepat harus dilakukan untuk penatalaksanaan yang tepat, dan pemeriksaan kausal harus dilakukan. Pasien pada umumnya mengalami manifestasi gastrointestinal, jantung dan neurologis yang seringkali berakibat fatal. Pengetahuan tentang EDS membantu menegakkan diagnosis dan memberikan pengobatan yang tepat untuk demam berdarah dengan manifestasi yang tidak biasa.
Multidrug-Resistant Organisms Infection on Mortality of Burn Patients at Public Hospital X in Jakarta: A Retrospective Study Veronica, Raja Merlinda; Kumalawati, July; Rumende, Cleopas Martin; Nainggolan, Leonard; Simadibrata, Marcellus; Shatri, Hamzah; Yunir, Em; Wardhana, Aditya; Nelwan, Erni Juwita; Rustam, Musfardi
Kesmas Vol. 19, No. 5
Publisher : UI Scholars Hub

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Abstract

Susceptibility to infection and increasing antibiotic resistance put burn patients at risk of developing infections caused by multidrug-resistant organisms (MDRO). This condition can progress to sepsis, increasing morbidity and mortality. This retrospective cohort study employed the medical record data of patients treated at Public Hospital X in Jakarta, Indonesia, from January 2020 to June 2022. Of 160 subjects, most were aged <60 years (82.5%) and had comorbidities (16.88%). The most common cause of burns was fire (86.25%). The use of medical devices was 90.63%, with a 14-day median length of stay. The most common gram-negative MDRO pathogens were K. pneumoniae (29.91%), Enterobacter sp (22.32%), and Acinetobacter (20.54%); 45% of patients infected with MDRO died. The bivariate analysis found an increased risk of death due to MDRO infection in burn patients (RR 1.103; 95%CI 1.004-1.211, p-value = 0.046). After adjusting for role variables (age, comorbidities, total body surface area, use of medical devices, length of stay) and from multivariate analysis, the confounding variables for MDRO infection and mortality were length of stay and age. MDRO infection increases the mortality rate in burn patients. Mortality in burn patients due to MDRO infection is greater than non-MDRO.
Co-Authors Aditya Wardhana Agustiawan Cleopas Martin Rumende E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Em Yunir, Em Erni Juwita Nelwan, Erni Juwita Kaonang, Mahardika Putri Kumalawati, July Leonard Nainggolan Marcellus Simadibrata Rustam, Musfardi Syahadatina Zulfikar, Deza Harati