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All Journal Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Medicamento
Dewi, Amaria
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Uji Toksisitas Ekstrak Etanol Temu Blenyeh (Curcuma purpurascens Blume) terhadap Ikan Zebra (Danio rerio) Dewi, Amaria; Pramiastuti, Oktariani; Nurhidayati, Lailiana Garna
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9483

Abstract

Toxicity testing is an initial step to evaluate the bioactivity of compounds that may exhibit toxic effects. In this study, zebrafish (Danio rerio) were used as the test animals. The rhizome of Curcuma purpurascens Blume is known to contain flavonoids, alkaloids, and tannins that potentially have toxic effects. The rhizome extract was standardized according to quality control tests. This study aimed to identify the toxic effects of the rhizome extract of Curcuma purpurascens and to determine its LC50 value. The toxicity test method used was acute toxicity testing in zebrafish, observing the mortality rate over a 96-hour period. Each aquarium contained 7 zebrafish, and the tested extract concentrations were 1000, 500, 250, 125, and 62.5 ppm. Mortality data were analyzed using the probit method with SPSS software to obtain the LC50 value, which represents the concentration that statistically causes 50% mortality of the test population within 24 hours. The results showed that the rhizome extract of Curcuma purpurascens exhibited toxic effects with an LC50 value of 83.7 ppm. This LC50 value falls within the toxic category based on toxicity test parameters. These findings indicate that the bioactive compounds in the rhizome extract, such as flavonoids, alkaloids, and tannins, which act as stomach poisons, cell proliferation inhibitors, and apoptosis inducers, can be toxic to normal human cells but may be useful in cancer treatment.
Edukasi Penggunaan Vitamin Neurotropik Bagi Guru KBIT Fatimatuz Zahro Pramiastuti, Oktariani; Istriningsih, Endang; Murti, Fiqih Kartika; Wulandari, Prihastini Setyo; Firsty, Girly Risma; Nurfauziah, Afina; Alquraisi, Rima Harsa Atqiya; Dewi, Amaria; Pramesti, Indah; Nisa, Khafidatun
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 1 (2025)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v6i1.5241

Abstract

Kerusakan saraf atau neuropati dapat disebabkan oleh berbagai faktor, termasuk penuaan, diabetes, cedera, dan defisiensi vitamin neurotropik seperti vitamin B1, B6, dan B12. Penanganan neuropati sangat penting dilakukan supaya tidak terjadi komplikasi. Untuk meningkatkan kualitas hidup penderita neuropati, edukasi kesehatan mengenai penyakit ini sangatlah penting. Pasien dan keluarga perlu diberikan pemahaman yang memadai tentang penyakit neuropati, mulai dari definisi hingga tata laksana yang tepat. Oleh sebab itu, dilakukan edukasi tentang penggunaan vitamin neurotropik kepada guru KBIT Fatimatuz Zahro. Pemberian edukasi dilakukan secara langsung menggunakan media power point dan pamflet. Kemudian dilakukan evaluasi untuk mengetahui tingkat pengetahuan peserta menggunakan metode pre dan post test. Hasil kegiatan yang telah dilakukan dapat meningkatkan pengetahuan guru KBIT Fatimatuz Zahro mengenai cara penggunaan vitamin neurotropik dengan persentase peningkatan pemahaman mencapai 79,63%. Hal ini dilihat dari hasil perolehan rata-rata nilai post test yang lebih tinggi dibandingkan rata-rata nilai pre test. Hasil analisis paired sample t-test menunjukkan signifikansi yang diperoleh sebesar 0,000 yang artinya tidak ada perbedaan yang signifikan antara hasil pre test dan post test.
Co-Authors Alquraisi, Rima Harsa Atqiya Fiqih Kartika Murti, Fiqih Kartika Firsty, Girly Risma Istriningsih, Endang Nisa, Khafidatun Nurfauziah, Afina Nurhidayati, Lailiana Garna Pramesti, Indah Pramiastuti, Oktariani Wulandari, Prihastini Setyo