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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Farmasi Klinik dan Sains Sahabat Sosial: Jurnal Pengabdian Masyarakat Usadha Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Sains dan Kesehatan Journal of Chemistry Sciences and Education Indenesian Journal of Tropical Biology Indenesian Journal of Tropical Biology
Nurhidayati, Lailiana Garna
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Promosi Kesehatan dan Pendampingan Tentang Flouride Dalam Upaya Mencegah Terjadinya Karies Gigi Anak Sallo, Andi Kamal M.; Asnur, Syamfitriani; Musaidah, Musaidah; Mardiah, Ainun; Nurhidayati, Lailiana Garna; Rejeki, Desi Sri
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2024): Sahabat Sosial: Jurnal Pengabdian Masyarakat (September)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v2i4.485

Abstract

Parents, especially mothers, have an important role in maintaining the health of their family members. The role of parents is very much needed in guiding, providing understanding, reminding, and providing facilities to children and their family members so that they can maintain their dental and oral hygiene. In efforts to care for teeth and mouth, the amount of information obtained by mothers will affect the efforts of the family's dental and oral health. Mothers will be better at teaching how to brush their teeth, arranging the correct snack patterns and various other efforts in maintaining the dental and oral hygiene of their family members, so that knowledge about dental and oral health will be better. The purpose of community service activities is that promotion about fluoride will increase mothers' knowledge in efforts to prevent dental caries and improve the level of dental and oral health in children. The service method with Health Promotion and Guidance About Fluoride in Efforts to Prevent Dental Caries in Children about fluoride as a promotional media to increase mothers' understanding of fluoride knowledge. The results of the Community Service activities are that knowledge about fluoride and the skills of how to brush teeth properly and correctly owned by mothers, improve the dental and oral health of their family members so that it will prevent the risk of dental caries, especially in their children. The conclusion of this activity is that there is an effort to prevent tooth decay by guiding children to always maintain the cleanliness of their teeth and mouth by brushing their teeth properly, correctly and regularly and using toothpaste containing fluoride.
Perbandingan Metode Ekstraksi terhadap Kadar Flavonoid Total Ekstrak Etanol Daun Kersen (Muntingia Calabura L.) Alfiraza, Ery Nourika; Nurhidayati, Lailiana Garna; Fahamsya, Arifina; Wahyuningtias, Arum
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5136

Abstract

Flavonoid compounds, triterpenes, tannins, polyphenols, and saponins can be found in cherry leaves (Muntingia calabura L.). Flavonoids are proven to be able to reduce free radicals, and thus can act as an antioxidant. The use of extraction methods can affect the content of flavonoid compounds contained in the extract . Thus, to extract flavonoids from plant leaves, it is necessary to optimize the right extraction method. Objective of this study was to compare the effect of using three different extraction methods, namely maceration, reflux, and sonication, on the total flavonoid content of cherry leaf ethanol extract. Cherry leaves were extracted with ethanol (1:10), using three different extraction methods, namely maceration, reflux, and sonication. The viscous extract obtained was then measured for total flavonoid content using UV-VIS spectrophotometry at 431 nm, using a standard solution of quercetin as a comparison. Total flavonoid content of ethanol extract of cherry leaf extracted by maceration, reflux, and sonication method respectively were 73.98 ± 0.06 mgQE/g; 60.55 ± 0.05 mgQE/g; and 92.53 ± 0.12 mgQE/g. Conclusion of this study was The extraction process influences the overall flavonoid concentration of cherry leaf ethanol extract.
Uji Toksisitas Ekstrak Etanol Temu Blenyeh (Curcuma purpurascens Blume) terhadap Ikan Zebra (Danio rerio) Dewi, Amaria; Pramiastuti, Oktariani; Nurhidayati, Lailiana Garna
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9483

Abstract

Toxicity testing is an initial step to evaluate the bioactivity of compounds that may exhibit toxic effects. In this study, zebrafish (Danio rerio) were used as the test animals. The rhizome of Curcuma purpurascens Blume is known to contain flavonoids, alkaloids, and tannins that potentially have toxic effects. The rhizome extract was standardized according to quality control tests. This study aimed to identify the toxic effects of the rhizome extract of Curcuma purpurascens and to determine its LC50 value. The toxicity test method used was acute toxicity testing in zebrafish, observing the mortality rate over a 96-hour period. Each aquarium contained 7 zebrafish, and the tested extract concentrations were 1000, 500, 250, 125, and 62.5 ppm. Mortality data were analyzed using the probit method with SPSS software to obtain the LC50 value, which represents the concentration that statistically causes 50% mortality of the test population within 24 hours. The results showed that the rhizome extract of Curcuma purpurascens exhibited toxic effects with an LC50 value of 83.7 ppm. This LC50 value falls within the toxic category based on toxicity test parameters. These findings indicate that the bioactive compounds in the rhizome extract, such as flavonoids, alkaloids, and tannins, which act as stomach poisons, cell proliferation inhibitors, and apoptosis inducers, can be toxic to normal human cells but may be useful in cancer treatment.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Dan Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Staphylococcus Aureus Anindya, Yuarinda Melly; Rejeki, Desi Sri; Nurhidayati, Lailiana Garna; Fakhrunnisa, Farida
Journal of Chemistry Sciences and Education Vol 1 No 02 (2024): Journal of Chemistry Sciences and Education
Publisher : PT. Pubsains Nur Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69606/jcse.v1i02.163

Abstract

Wuluh starfruit (Averrhoa bilimbi L.) and green betel (Piper betle L.) leaves are medicinal plants that have antibacterial properties. Medicinal plants can be used as alternative medicine to obtain new compounds as antibacterial. The chemical compounds in wuluh starfruit leaves that have antibacterial properties are flavonoids, saponins and tannins, while green betel leaves have flavonoids, saponins, tannins and essential oils. The study aimed to determine the antibacterial activity of a combination of wuluh starfruit and green betel leaves extract against the growth of Staphylococcus aureus. The experimental research used a diffusion method by disc paper based on the diameter of the inhibition zone or the clear area formed around the paper disc. The extracts were obtained by maceration method using 96% ethanol solvent. The values of the inhibition zone in four concentrations; 5%, 10%, 15%, and 20% were respectively 13 mm, 13.5 mm, 15 mm, and 16 mm. On the other hand, the concentration of 20% had the most effective inhibition zone with a strong category against Staphylococcus aureus.  
Peningkatan Perilaku Hidup Bersih Dan Sehat (Phbs) Melalui Edukasi Kesehatan Pada Masyarakat Di Lingkungan Permukiman Padat Penduduk Hilal, Achmad; Nurhidayati, Lailiana Garna; Rosdiana, Rosdiana; Rusnita, Rusnita; Anto, Sardi
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 3 No. 3 (2025): Sahabat Sosial: Jurnal Pengabdian Masyarakat (Juni)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v3i3.702

Abstract

Clean and Healthy Living Behavior (PHBS) is one of the promotive and preventive efforts in the field of public health. Densely populated areas are vulnerable to various health problems due to density and limited sanitation facilities. This community service aims to improve understanding and practice of PHBS through health education activities. Activity methods include counseling, demonstrations, and mentoring involving the local community. The results of the activities show increased knowledge and positive behavioral changes in aspects of personal hygiene, waste management, and use of clean water. Health education has proven effective as an initial approach in forming a society that is aware of the importance of clean and healthy living.
Aktivitas Antibakteri Sediaan Facial Wash Ekstrak Etanol Daun Patikan Kebo terhadap Propionibacterium acnes Alfiraza, Ery Nourika; Nurhidayati, Lailiana Garna; Nisa, Sinta Khoiri; Murti, Fiqih Kartika
KUNIR: JURNAL FARMASI INDONESIA Vol 1 No 1 (2023): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v1i1.529

Abstract

Facial wash merupakan sabun pembersih wajah yang dapat membersihkan lapisan minyak di kulit wajah sekaligus kotoran penyebab jerawat. Salah satu tanaman obat di Indonesia yang memiliki senyawa antibakteri untuk melawan bakteri penyebab jerawat adalah daun patikan kebo (Euphorbia hirta L.). Hal ini didukung dengan kandungan bioaktif pada daun patikan kebo yang mempunyai aktivitas antibakteri seperti flavonoid, alkaloid, tanin, saponin, steroid, dan terpenoid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada facial wash ekstrak etanol daun patikan kebo terhadap bakteri Propionibacterium acnes. Formulasi facial wash dengan variasi konsentrasi ekstrak etanol daun patikan kebo 1%, 2% dan 3% serta evaluasi sediaan meliputi uji organoleptis, uji homogenitas, uji pH, uji viskositas, uji tinggi busa dan uji akitivitas antibakteri facial wash ekstrak daun patikan kebo terhadap bakteri Propionibacterium acnes dengan metode sumuran. Hasil penelitian menunjukkan bahwa sediaan facial wash dari masing-masing konsentrasi memenuhi persyaratan uji sifat fisik. Hasil rata-rata zona hambat pada konsentrasi 0%, 1%, 2% dan 3% berturut-turut adalah 0 mm, 6,08 mm, 7 mm dan 8,16 mm. Semakin tinggi konsentrasi ekstrak etanol daun patikan kebo pada sediaan facial wash, maka semakin tinggi aktivitas antibakterinya.
Analisis Kadar Vitamin C Buah Pepaya California Mentah (Carica papaya L.) dengan Metode Spektrofotometri UV-Vis Nurhidayati, Lailiana Garna; Pramiastuti, Oktariani; Ningrum, Ayu Puspita; Nurfauziah, Afina
KUNIR: JURNAL FARMASI INDONESIA Vol 1 No 1 (2023): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v1i1.530

Abstract

Vitamin C merupakan zat gizi yang berperan sebagai antioksidan yang mampu mengatasi radikal bebas yang dapat merusak jaringan atau sel, serta meningkatkan daya tahan tubuh yang akan diserap oleh kalsium dalam tubuh. Vitamin C banyak terdapat pada buah dan sayuran, salah satunya dalam buah pepaya california. Penelitian ini mengenai analisis kadar vitamin C di dalam buah pepaya california yang masih mentah. Tujuan dari penelitian ini untuk mengetahui kadar vitamin C yang terkandung pada buah pepaya california mentah. Metode penelitian meliputi pengumpulan sampel, determinasi tanaman, pengolahan sampel, analisis kualitatif dan kuantitatif. Analisis kualitatif dengan menggunakan pereaksi iodium, FeCl3 1%, Benedict dan pereaksi fehling A dan B, sedangkan pada analisis kuantitatif dengan menggunakan metode spektrofotometri UV-Vis dan analisis data menggunakan persamaan regresi linier. Hasil analisis kualitatif menunjukkan bahwa di dalam buah pepaya california mentah terdapat kandungan vitamin C. Panjang gelombang maksimum vitamin C yang diperoleh adalah 266,20 nm dengan nilai absorbansi 0,213. Persamaan regresi linier yang diperoleh adalah y = 0,0557x+0,1038, sehingga diperoleh kadar vitamin C pada buah pepaya california mentah sebesar 0,01638% dengan menggunakan spektrofotometri UV-Vis. Hasil menunjukkan bahwa buah pepaya california mentah (Carica papaya L.) terdapat kandungan vitamin C dan memiliki kadar vitamin C sebesar 0,01638%.
Formulasi Nanoemulsi Sediaan Face Mist Ekstrak Tomat (Solanum Lycopersicum L.) dan Sari Lidah Buaya (Aloe Vera L.) untuk Melembabkan Wajah: Formulation of Nanoemulsion Face Mist Preparation with Tomato Extract (Solanum Lycopersicum L.) and Juice Aloe Vera (Aloe Vera L.) for Face Moisturizing Nida, Laelatun; Nurhidayati, Lailiana Garna; Cahyanta, Agung Nur
Jurnal Sains dan Kesehatan Vol. 7 No. 5 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i5.2557

Abstract

Face mist is a cosmetic preparation used to whiten and moisturize facial skin. This study aimed to formulate and evaluate a nanoemulsion face mist combining tomato extract (Solanum lycopersicum L.) and aloe vera juice (Aloe vera L.) as a natural moisturizer. The nanoemulsion was prepared by mixing oil and water phases using a magnetic stirrer. Evaluations included organoleptic test, pH, homogeneity, viscosity, spray pattern, drying time, stability, skin hydration, particle size, and hedonic test. The best stability was found in Formula 3, containing 0.75% tomato extract and 4.75% aloe vera. This formula showed a particle size of 16.6 nm, a polydispersity index of 0.331, and the highest skin moisture increase was observed in Formula 2 at 51.33% after 21 days. The results suggest that ripe tomato extract and aloe vera can be successfully formulated into a nanoemulsion face mist as a facial moisturizer. Keywords:          nanoemulsion, face mist, tomato, aloe vera, facial moisturizer   Abstrak Face mist adalah sediaan kosmetik yang berfungsi untuk memutihkan dan melembabkan kulit wajah. Penelitian ini bertujuan memformulasikan dan mengevaluasi sediaan nanoemulsi face mist kombinasi ekstrak tomat (Solanum lycopersicum L.) dan sari lidah buaya (Aloe Vera L.) sebagai pelembab alami. Nanoemulsi dilakukan dengan mencampurkan fase minyak dan fase air menggunakan magnetic stirrer. Evaluasi yang dilakukan seperti uji organoleptik, pengukuran pH, pemeriksaan homogenitas, viskositas, serta uji stabilitas, kelembapan kulit dan ukuran partikel. Formulasi terbaik dilihat pada uji stabilitas diperoleh pada Formula 3 dengan komposisi 0,75% ekstrak tomat dan 4,75% sari lidah buaya. Sediaan ini menunjukkan ukuran partikel 16,6nm, indeks polidispersitas 0,331, serta perubahan kelembaban kulit paling tinggi pada formula 2 sebesar 51,33% setelah penggunaan 21 hari. Hasil penelitian memberikan bahwa ekstrak tomat matang dan lidah buaya dapat diformulasikan ke dalam sediaan nanoemulsi face mist sebagai produk pelembap wajah. Kata Kunci:         Nanoemulsi, face mist, tomat, lidah buaya, pelembab wajah
Uji Aktivitas Afrodisiaka Sediaan Tablet Effervescent Ekstrak Kombinasi Buah Pare (Momordica Charantia L.) Dan Bawang Putih (Allium Sativum L.) Pada Mencit Putih Jantan (Mus Musculus L.) Listina, Osie; Nurhidayati, Lailiana Garna; Fia, Nela Selfi Nur Okta
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7467

Abstract

Aphrodisiacs are substances derived from food or medicine that can enhance sexual desire. This study aimed to evaluate the aphrodisiac activity of effervescent tablet formulations containing extracts of bitter melon (Momordica charantia L.) and garlic (Allium sativum L.), both individually and in combination, in male white mice (Mus musculus L.). The ICC method (Introduction, Climbing, Coitus) was applied to 25 male Wistar mice divided into five groups. Group I served as the negative control and received distilled water orally. Group II was administered an effervescent tablet solution containing bitter melon extract at a single dose of 980 mg/kg BW. Group III received an effervescent tablet solution containing garlic extract at a single dose of 150 mg/kg BW. Group IV was given a combination effervescent tablet solution at a ½:½ ratio (bitter melon extract 490 mg/kg BW and garlic extract 75 mg/kg BW). Group V received a combination effervescent tablet solution at a 1:1 ratio (bitter melon extract 980 mg/kg BW and garlic extract 150 mg/kg BW). Observations were conducted for 2 hours, recording the frequency of ICC behaviors. Data were analyzed using SPSS with ANOVA followed by Post Hoc tests. The results showed that all treatment groups exhibited significant differences in aphrodisiac activity, with the highest frequency observed in the 1:1 combination of bitter melon extract (980 mg/kg BW) and garlic extract (150 mg/kg BW) compared to other effervescent tablet formulations.
Formulasi dan Evaluasi Sediaan Body Scrub Bunga Telang (Clitoria ternatea L.) dan Sabut Kelapa (Cocos nucifera L.) sebagai Antioksidan Nurhidayati, Lailiana Garna; Rejeki, Desi Sri; Fauziah, Silvia Novi Nur
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.573

Abstract

Bunga telang merupakan tanaman yang mengandung senyawa fitokimia flavonoid, alkaloid, tanin, saponin, terpenoid dan steroid. Sabut kelapa digunakan sebagai scrub karena memiliki tekstur kasar. Antioksidan adalah senyawa yang memiliki kemampuan untuk menangkap atau menetralisasi radikal bebas, sehingga dapat melindungi tubuh dari penyakit yang merusak secara perlahan seperti gangguan jantung, kanker, dan penyakit lainnya. Tujuan penelitian ini untuk mengetahui apakah  ekstrak etanol bunga telang dan sabut kelapa dapat diformulasikan dalam sediaan body scrub dan mengetahui aktivitas antioksidan pada sediaan. Metode penelitian ini adalah eksperimental. Ekstraksi bunga telang dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak bunga telang dibuat sediaan body scrub dengan konsentrasi 0%, 5%, 10% dan 15% sedangkan sabut kelapa dengan konsentrasi 0% pada F0 dan 6% pada F1, F2, F3, dan F4. Hasil penelitian menunjukkan sediaan yang berbentuk semi padat, beraroma vanilla, berwarna putih kekuningan pada F0, cokelat pada F1 & F2, cokelat kehijauan pada F3 dan hijau pada F4. Sediaan memenuhi syarat uji homogenitas, uji pH, uji daya sebar, uji daya lekat. Tipe emulsi semua sediaan yaitu minyak dalam air (M/A). Hasil uji hedonik sediaan yang paling banyak disukai yaitu F2 pada parameter warna dan tekstur, F0 pada parameter aroma. Penentuan aktivitas antioksidan dengan metode DPPH pada panjang gelombang 516,0 nm, dihasilkan ekstrak etanol bunga telang memiliki nilai IC50 34,400 ppm (sangat kuat), F1 132,245 ppm (sedang), F2 77,949 ppm, F3 67,101 ppm dan F4 58,810 ppm (kuat). Sediaan yang paling tinggi memiliki aktivitas antioksidan yaitu F4.
Co-Authors Agung Nur Cahyanta, Agung Nur Ainun Mardiah Alfiraza, Ery Nourika Andi Kamal M. Sallo Anindya, Yuarinda Melly Desi Sri Rejeki Dewi, Amaria Diana, Intan Mauli Fahamsya, Arifina Farida Fakhrunnisa, Farida Fauziah, Silvia Novi Nur Fia, Nela Selfi Nur Okta Fiqih Kartika Murti, Fiqih Kartika Fitriani, Lisna Annisa Hilal, Achmad Krisdiantho, Roos Kemal Listina, Osie Musaidah Musaidah Nida, Laelatun Ningrum, Ayu Puspita Nisa, Sinta Khoiri Nurfauziah, Afina Pramiastuti, Oktariani Rosdiana Rosdiana Rusnita, Rusnita Sapitri, Anis Sardi Anto Vandani, Chiara Dhinta Wahyuningtias, Arum