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All Journal Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences.
Ananda, Meisya Dwi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Pharmacological Benefits Extracts of Putri Malu (Mimosa pudica Linn.) in Herbal Medicine: A Review Ananda, Meisya Dwi; Mierza, Vriezka; Khaerunisa, Aulia; Apriani, Risa Dwi
Jurnal Pijar Mipa Vol. 19 No. 6 (2024): November 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i6.8017

Abstract

Herbal medicine has a long history of use as an alternative therapy, especially for acute and chronic diseases. There have been many studies on the Putri Malu plant (Mimosa pudica Linn.) to uncover its pharmacological activities. This review paper aims to examine the secondary metabolites present in the extracts of the plant putri malu (Mimosa pudica Linn.) and their potential pharmacological actions. The method used was a Systematic Literature Review (SLR), which collected publications from PubMed, ScienceDirect, and Google Scholar databases. From this process, 15 studies were identified that met the predetermined inclusion criteria. Most of the studies used extracts of the leaves putri malu (Mimosa pudica Linn.) with ethanol solvent as the leading choice for extraction. The pharmacological activities found include antioxidant (20%), anti-inflammatory, anticancer, and antidiabetic (13.3% each) and contain antibacterial, anticonvulsant, antihelminthic, diuretic, hepatoprotective, antimalarial, antidepressant, and antihyperlipidemic (6.7% each). In conclusion, extracts of the plant putri malu (Mimosa pudica Linn.) show great potential for use in herbal medicine. Its wide range of pharmacological actions backs its advantages in treating and preventing several illnesses.
Potential Bioactivity of Guava Leaf Extract (Psidium guajava L.) as a Natural Therapeutic Agent: A Review Risa, Risa Dwi; Septiani, Dia; Faoziyyah, Nabilla; Ananda, Meisya Dwi
Jurnal Pijar Mipa Vol. 20 No. 5 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i5.8080

Abstract

Guava leaves (Psidium guajava L.) from the family Myrtaceae are known to have many health benefits. This review identifies the main active compounds in guava leaves, such as flavonoids, tannins, saponins, and terpenoids, which contribute to its pharmacological activities. The purpose of this article is to evaluate the effectiveness and safety of guava leaves in providing therapeutic effects, such as antimicrobial, anti-inflammatory, and anticancer activities. A literature review with a qualitative approach of 10 articles was used in this research. Research shows that guava leaf extract is effective as an antidiabetic by inhibiting α the α-amylase enzyme and regulating glucose uptake. In addition, this extract functions as an antioxidant to fight free radicals, as well as an immunomodulator that increases phagocyte activity. The antibacterial and anti-inflammatory activities of this extract can inhibit the growth of pathogenic microbes and suppress inflammatory responses, making it potentially useful for the treatment of infection and inflammation. Anticancer activity has also been demonstrated, mainly through inhibition of cancer signalling pathways and induction of apoptosis. Thus, guava leaves have prospects as a potential natural ingredient for the development of herbal medicines to treat various health conditions, especially enzyme inhibition, increased phagocyte activity, and inhibition of inflammation and pathogenic microbial growth.
Interaksi Obat Pada Pasien Geriatri: Kajian Berbasis Evidence Tentang Kombinasi Antihipertensi dan Obat Non Steroidal Anti-Inflammatory Alya, Rahma; Khuriyah, Khuriyah; Ananda, Meisya Dwi; Putra, Hasan Etanov; Adzkia, Muhammad Adit; Putri, Mukarromah Dita; Hilmi, Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1182

Abstract

The number of elderly individuals continues to increase globally, accompanied by a high prevalence of chronic diseases, particularly hypertension and musculoskeletal disorders. This condition makes geriatric patients vulnerable to polypharmacy, which increases the risk of drug interactions, one of which is between antihypertensives and non-steroidal anti-inflammatory drugs (NSAIDs). Such interactions can potentially reduce therapy effectiveness, cause electrolyte disturbances, and lead to acute kidney injury (AKI). This study aims to comprehensively examine the interaction between antihypertensives and NSAIDs in geriatric patients and its impact on therapy safety. The method used is a literature review by selecting national and international articles published between 2015 and 2025, written in either Indonesian or English, specifically investigating interactions between antihypertensives (β-blockers, ACE inhibitors, ARBs, diuretics, and CCBs) and NSAIDs. The review results indicate that most interactions are pharmacodynamic, involving either antagonism or negative synergism. NSAIDs can reduce the effectiveness of antihypertensive therapy through mechanisms such as sodium retention, afferent arteriolar vasoconstriction, and decreased renal perfusion. In certain combinations, such as the triple whammy phenomenon (NSAIDs, diuretics, and RAAS inhibitors), the risk of AKI and hyperkalemia increases significantly. This risk is higher in geriatric patients with decreased kidney function, comorbidities, and concurrent use of multiple drugs. In conclusion, the interaction between antihypertensives and NSAIDs in the elderly population is an important clinical issue. Therefore, close monitoring of kidney function and electrolytes, using the lowest effective dose for the shortest possible duration, and patient education to avoid self-medication are necessary to ensure therapy safety.
Co-Authors Adzkia, Muhammad Adit Alya, Rahma Apriani, Risa Dwi Faoziyyah, Nabilla Indah Laily Hilmi Khaerunisa, Aulia Khuriyah . Mierza, Vriezka Putra, Hasan Etanov Putri, Mukarromah Dita Risa, Risa Dwi Septiani, Dia