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All Journal Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences.
Apriani, Risa Dwi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Pharmacological Benefits Extracts of Putri Malu (Mimosa pudica Linn.) in Herbal Medicine: A Review Ananda, Meisya Dwi; Mierza, Vriezka; Khaerunisa, Aulia; Apriani, Risa Dwi
Jurnal Pijar Mipa Vol. 19 No. 6 (2024): November 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i6.8017

Abstract

Herbal medicine has a long history of use as an alternative therapy, especially for acute and chronic diseases. There have been many studies on the Putri Malu plant (Mimosa pudica Linn.) to uncover its pharmacological activities. This review paper aims to examine the secondary metabolites present in the extracts of the plant putri malu (Mimosa pudica Linn.) and their potential pharmacological actions. The method used was a Systematic Literature Review (SLR), which collected publications from PubMed, ScienceDirect, and Google Scholar databases. From this process, 15 studies were identified that met the predetermined inclusion criteria. Most of the studies used extracts of the leaves putri malu (Mimosa pudica Linn.) with ethanol solvent as the leading choice for extraction. The pharmacological activities found include antioxidant (20%), anti-inflammatory, anticancer, and antidiabetic (13.3% each) and contain antibacterial, anticonvulsant, antihelminthic, diuretic, hepatoprotective, antimalarial, antidepressant, and antihyperlipidemic (6.7% each). In conclusion, extracts of the plant putri malu (Mimosa pudica Linn.) show great potential for use in herbal medicine. Its wide range of pharmacological actions backs its advantages in treating and preventing several illnesses.
Interaksi Obat-Herbal dengan Agen Hormon dalam Terapi Kanker: Tinjauan Mekanisme dan Implikasi Klinis Zulqifli, Iqbal; Hikmah, Nurul; Shella, Tasya Permata; Azizah, Nabilla Faoziyyah; Apriani, Risa Dwi; Putri, Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1073

Abstract

Hormone therapy is the cornerstone of treatment for hormone-dependent cancers, such as breast and prostate cancer. On the other hand, the high rate of herbal medicine use as complementary treatment in cancer patients has the potential to cause herbal drug interactions (HDIs), which can affect the efficacy and safety of the primary therapy. This study aims to identify and categorize drug-herbal interactions (DHIs) in cancer hormone therapy based on pharmacokinetic mechanisms (including CYP450 enzyme and drug transporter modulation) and pharmacodynamic mechanisms (including hormone receptor and signaling pathway modulation), as well as to conclude their clinical implications. A systematic review was conducted following the PRISMA-ScR guidelines. A literature search was performed in the PubMed, Scopus, ScienceDirect, Frontiers, and Google Scholar databases for relevant in silico, in vitro, and in vivo studies published between 2015 and 2025. Analysis showed that HDI can be categorized into two main groups. First, pharmacokinetic interactions that occur through the modulation of cytochrome P450 (CYP) enzymes and drug transporters, such as the reduction in the bioavailability of tamoxifen by Hedyotis diffusa. Second, pharmacodynamic interactions at hormone receptors, such as the synergistic effect between Boswellia serrata and enzalutamide. The nature of interactions varies greatly, from antagonistic to synergistic, depending on the specific herbal-drug pair. These findings emphasize the importance of clinical vigilance, such as open communication with patients, dose adjustments, therapeutic monitoring, and interprofessional collaboration. These measures are necessary to reduce the risk of HDI and improve the efficacy of cancer therapy.
Co-Authors Ananda, Meisya Dwi Azizah, Nabilla Faoziyyah Hilmi , Indah Laily Khaerunisa, Aulia Mierza, Vriezka Nurul Hikmah Putri, Mukarromah Dita Shella, Tasya Permata Zulqifli, Iqbal