Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences.
Khaerunisa, Aulia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Pharmacological Benefits Extracts of Putri Malu (Mimosa pudica Linn.) in Herbal Medicine: A Review Ananda, Meisya Dwi; Mierza, Vriezka; Khaerunisa, Aulia; Apriani, Risa Dwi
Jurnal Pijar Mipa Vol. 19 No. 6 (2024): November 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i6.8017

Abstract

Herbal medicine has a long history of use as an alternative therapy, especially for acute and chronic diseases. There have been many studies on the Putri Malu plant (Mimosa pudica Linn.) to uncover its pharmacological activities. This review paper aims to examine the secondary metabolites present in the extracts of the plant putri malu (Mimosa pudica Linn.) and their potential pharmacological actions. The method used was a Systematic Literature Review (SLR), which collected publications from PubMed, ScienceDirect, and Google Scholar databases. From this process, 15 studies were identified that met the predetermined inclusion criteria. Most of the studies used extracts of the leaves putri malu (Mimosa pudica Linn.) with ethanol solvent as the leading choice for extraction. The pharmacological activities found include antioxidant (20%), anti-inflammatory, anticancer, and antidiabetic (13.3% each) and contain antibacterial, anticonvulsant, antihelminthic, diuretic, hepatoprotective, antimalarial, antidepressant, and antihyperlipidemic (6.7% each). In conclusion, extracts of the plant putri malu (Mimosa pudica Linn.) show great potential for use in herbal medicine. Its wide range of pharmacological actions backs its advantages in treating and preventing several illnesses.
Advancements in Modern Biotechnology for Enhanced Kojic Acid Production in the Cosmetic Industry: A Review Herlaesa, Shofiatulfuadah Retnaningrum; Muini, Chantiara F. M.; Khaerunisa, Aulia
Jurnal Pijar Mipa Vol. 20 No. 6 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i6.10034

Abstract

Kojic acid (KA), a secondary metabolite from Aspergillus species, is widely used in the cosmetic industry as a skin-lightening agent, antioxidant, and anti-aging ingredient. With the growing demand for natural and effective skincare products, there is an increasing interest in sustainable and scalable KA production. Conventional fermentation methods remain limited by low yields, long incubation periods, and high costs. Advances in biotechnology now provide more efficient and reliable alternatives to overcome these challenges. This systematic review of studies published between 2020 and 2025 highlights recent developments in genetic engineering and process optimization for KA production. CRISPR/Cas9-based editing of regulatory genes such as kojR and the promoter region of kojA has improved production stability and yield, with increases reported up to 43 percent. Mutagenesis approaches using UV, gamma irradiation, microwave exposure, and atmospheric plasma have produced hyperproductive strains, with some reaching 96.5 g/L KA, representing a 293 percent increase compared with parental strains. In addition, novel regulatory proteins, including AoZFA and Aokap2, have been identified as key molecular factors controlling KA biosynthesis. Fermentation optimization also contributes significantly to efficiency. Adjustments in pH and temperature, the addition of metal ions such as Zn²⁺ and Pb²⁺, and the use of alternative substrates like sugarcane bagasse or sorghum sheaf have been shown to improve yields and reduce costs. These strategies not only increase production but also align with the demand for sustainable raw materials. Overall, integrating advanced genetic tools with optimized fermentation systems provides a strong platform for industrial-scale KA production. Modern biotechnology demonstrates clear potential to meet the requirements of the cosmetic industry while ensuring product safety, consistency, and scalability.
Evaluasi Bukti dari Uji Klinis tentang Interaksi Antibiotik dan Antasida: Suatu Tinjauan Sistematis Literatur Al Qindy, Wildan Hidayah; Nurdin, Fitri Oktaviani; Khaerunisa, Aulia; Putri, Meisya Diffa Amalia; Hilmi, Indah Laily; Putri, Mukarromah Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1093

Abstract

Drug interactions between antibiotics and antacids represent an important clinical issue that can affect therapeutic efficacy and increase the risk of treatment failure. The concurrent use of these drug classes frequently occurs in clinical practice, particularly in patients receiving antibiotic therapy who also present with gastrointestinal complaints. This systematic literature review aims to evaluate the clinical trial evidence regarding antibiotic–antacid interactions, focusing on pharmacokinetic and pharmacodynamic mechanisms, clinical implications, and current research limitations. Relevant articles were identified through PubMed, Google Scholar, and other scientific databases using standardized keywords. Literature selection followed the PRISMA guidelines to ensure the quality and relevance of included studies. The analysis revealed that antacids and proton pump inhibitors (PPIs) can significantly reduce the bioavailability of antibiotics, especially fluoroquinolones and tetracyclines, through chelation with metal ions and by increasing gastric pH, thereby impairing drug absorption. Concomitant use of antibiotics and PPIs was also associated with a higher risk of Clostridioides difficile infection (CDI), particularly in elderly or comorbid patients. Conversely, newer acid-suppressing agents such as vonoprazan demonstrated good efficacy in Helicobacter pylori eradication regimens without compromising antibiotic activity. Despite these findings, most studies were retrospective, with limited sample sizes and specific populations. Therefore, large-scale prospective clinical trials are needed to strengthen the evidence base. A comprehensive understanding of antibiotic–antacid interactions is essential to support rational, safe, and effective prescribing practices in clinical settings.
Co-Authors Al Qindy, Wildan Hidayah Ananda, Meisya Dwi Apriani, Risa Dwi Herlaesa, Shofiatulfuadah Retnaningrum Indah Laily Hilmi Mierza, Vriezka Muini, Chantiara F. M. Nurdin, Fitri Oktaviani Putri, Meisya Diffa Amalia Putri, Mukarromah Dita