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All Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan International Journal of Cell and Biomedical Science
Amellia, Nazzala Luthfin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Regulatory Effect of Secretome-Hypoxia Preconditioned Mesenchymal Stem Cells on TNF-α Level in Streptozotocin-induced Rats Amellia, Nazzala Luthfin; Antari, Arini Dewi; Nazar, Mohammad Ariq; Husain, Sofian Azalia; Arifin, Naufal Ardjivani
International Journal of Cell and Biomedical Science Vol 1 No 3 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i3.23

Abstract

Background: Type 1 Diabetic Mellitus (T1DM) is a well-known autoimmune disease characterized by a specific adaptative immunity against β-cell antigens. Mesenchymal stem cells (MSC) have emerged as potential immunomodulators in a paracrine manner via their bioactive soluble molecules that involve inflammation-related diseases, including T1DM. Objective: This study aims to investigate the effect of SHMSCs on regulating TNF-α concentrations in STZ-induced rats. Materials and Methods: This study uses a post-only control group design and randomized system that was conducted from December 2022 until January 2023. To induce T1DM-like rats, an intraperitoneal injection (65 mg/kg BW) of streptozotocin (STZ) was inducted. 15 male Wistar rats were subdivided into the following groups: STZ, STZ with 0.5 cc SHMSCs (Low-dose), and STZ with 1 cc SHMSCs (High-dose). The animals received an intraperitoneal injection of SHMSCs once a week for up to 4 weeks. On day 28, the animals were terminated and ELISA measured TNF-α concentrations. Results: After SHMSCs administration, the level of TNF-α in the treated group was decreased in either low-dose or high-dose groups compared with the STZ group. Conclusion: Administration of secretome-hypoxia MSCs may regulate TNF-α concentrations in STZ-induced Rats.
Upaya peningkatan pengetahuan berhenti merokok melalui edukasi dan peragaan bahaya rokok dengan alat sederhana Kurniawan, Yuwono Tulus; Artanti, Sekar Arum; Fitrianisa, Nadya; Indriatno, Anang Wiwik; Wardhana, Naufal Al Faris; Khairunnisa, Sekarayu Septia; Amellia, Nazzala Luthfin; Dewa, Yusuf Kusuma; Pratami, Rani Windasari; Damayanti, Indy Anindya; Nafisyah, Nafisyah; Egan, Zahir Khan Gaddy Shaquille; Nisaa, Salsabila Amarti; Dea, Salsabila Ratna; Octavia, Tania; Zulaikhah, Siti Thomas; Prasetijono, Purwito Soegeng; Suparmi, Suparmi
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 3 (2025): May
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i3.30202

Abstract

Abstrak Hasil analisa situasi menunjukkan bahwa indikator keberhasilan Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK) di RW 02 Kelurahan Bangetayu Kulon, Kota Semarang untuk anggota keluarga tidak ada yang merokok baru mencapai 36,7% dari target 100%. Tingginya perokok di RW ini saah satunya disebabkan oleh rendahnya tingkat pengetahuan masyarakat tentang bahaya merokok. Pengabdian kepada masyarakat (PkM) ini bertujuan untuk mengetahui tingkat pengetahuan mengenai bahaya merokok bagi kesehatan sebelum dan sesudah edukasi dan peragaan bahaya rokok dengan alat sederhana. . Pelaksanaan PkM melaiputi 3 tahapan yaitu persiapan berupa analisa situasi menggunakan kuesioner PIS-PK dan mawas diri, edukasi dan evaluasi menggunakan kuesioner pretest dan posttest. Edukasi berupa penyuluhan dengan tema “Lepaskan Rokok, Gapai Awet Sehat (LEGA)”. Edukasi menggunakan media leaflet, powerpoint,video dan alat peraga. Tingkat pengetahuan peserta  pada saat pre test  sebesar 6,00±1,75 dan posttest sebesar 8.34 ±1,45, sehingga terdapat peningkatan pengetahuan sebesar 28,05%. Hasil uji Wilcoxon menunjukkan bahwa terdapat perbedaan yang signifikan (p<0.05) antara tingkat pengetahuan peserta sebelum dan sesudah edukasi Edukasi dan peragaan bahaya rokok dengan alat sederhana terbukti dapat meningkatkan tingkat pengetahuan untuk berhenti merokok bagi warga RW 02 Kelurahan Bangetayu Kulon, Kota Semarang. Upaya menurunkan bahaya rokok di masyarakat perlu memperoleh dukungan dari semua pihak diantaranya keluarga, tokoh masyarakat dan puskesmas. Tindak lanjut yang bisa dilakukan adalah pemasangan poster bahaya merokok di pojok rokok untuk terus mengedukasi masyarakat tentang bahaya rokok. Kata kunci: rokok; edukasi; leaflet; video; alat peraga.. Abstract The situational analysis showed that the success indicator of the Healthy Indonesia Program with a Family Approach (PIS-PK) in RW 02, Bangetayu Kulon Subdistrict, Semarang City, for the criterion of having no family members who smoke has only reached 36.7% of the 100% target. The high number of smokers in this area is partly due to the low level of public knowledge about the dangers of smoking. This community service (PkM) aims to assess the level of knowledge regarding the health hazards of smoking before and after education and demonstrations using simple tools. The implementation of the PkM consists of three stages: preparation (including situational analysis using the PIS-PK questionnaire and self-assessment), education, and evaluation using pretest and posttest questionnaires. The education activity carried the theme "Lepaskan Rokok, Gapai Awet Sehat (LEGA)" or “Let Go of Cigarettes, Embrace Lasting Health.” It used leaflets, PowerPoint presentations, videos, and simple demonstration tools. The participants’ knowledge score increased from a pretest average of 6.00±1.75 to a posttest average of 8.34±1.45, indicating a 28.05% improvement. The Wilcoxon test results showed a significant difference (p<0.05) between participants' knowledge levels before and after the educational session. Education and demonstrations using simple tools proved effective in increasing knowledge about quitting smoking among residents of RW 02, Bangetayu Kulon Subdistrict, Semarang City. Efforts to reduce the dangers of smoking in the community require support from all parties, including families, community leaders, and health centers. A recommended follow-up action is to install anti-smoking posters in smoking corners to continuously educate the public about the dangers of smoking. Keywords: : smoking; education; leaflet; video; teaching aids.
Co-Authors Antari, Arini Dewi Arifin, Naufal Ardjivani Artanti, Sekar Arum Damayanti, Indy Anindya Dea, Salsabila Ratna Dewa, Yusuf Kusuma Egan, Zahir Khan Gaddy Shaquille Fitrianisa, Nadya Husain, Sofian Azalia Indriatno, Anang Wiwik Khairunnisa, Sekarayu Septia Kurniawan, Yuwono Tulus Nafisyah, Nafisyah Nazar, Mohammad Ariq Nisaa, Salsabila Amarti Octavia, Tania Prasetijono, Purwito Soegeng Pratami, Rani Windasari Siti Thomas Zulaikhah Suparmi Suparmi Wardhana, Naufal Al Faris