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Pakingki, Priska
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antibacterial Activity Of Staphylococcus aureus From Chinese Betel Leaf Juice (Peperomia pellucida L.) Wantah, Kezia T.; Kanter, Jabes W.; Tulandi, Selvana S.; Mongi, Jeane; Palandi, Reky R.; Pakingki, Priska
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.452

Abstract

Infectious diseases, especially in developing countries such as Indonesia, are a common health problem, one of which is caused by bacteria. This study tested the antibacterial activity of Chinese betel leaf extract against Staphylococcus aureus bacteria, with secondary metabolite content such as alkaloids, tannins, and flavonoids that act as antibacterials. This study was a laboratory experiment using a completely randomized design with three repetitions at five concentrations of extract, as well as one positive and negative control. The method used was the agar diffusion method, and the test results showed that Chinese betel leaf extract had antibacterial potential against Staphylococcus aureus at various concentrations tested. The concentrations used were 6µL/disc, 8µL/disc, 10µL/disc, 12µL/disc, and 14µL/disc, where all these categories produced inhibition zones included in the moderate category according to Susanto (2012). Statistical analysis using the Kruskal-Wallis test produced a significant value of 0.035 (<0.05), indicating a significant difference between each concentration tested. From the research results, it can be concluded that Chinese betel leaf extract has effective antibacterial activity against Staphylococcus aureus.
Antibacterial Activity Test of Sonneratia alba Mangrove Root Infusa Against Propionibacterium acnes and Salmonella typhi Bacteria Christin, Andriany M.; Mongi, Jeane; Kanter, Jabes W.; Maarisit, Wilmar; pakingki, Priska; Tombuku, Joke L.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.453

Abstract

Infectious diseases can be caused by microbiological agents, namely bacteria. The ability of bacteria to invade and cause infection is referred to as a pathogenicity. The results of phytochemical screening produced secondary metabolite compounds alkaloids, flavonoids, tannins, saponins, phenolics that act as antibacterial. This study aims to determine the antibacterial activity of Sonneratia alba mangrove root infusa against Propionibacterium acnes and Salmonella typhi bacteria. This type of research is a laboratory experimental research, using the well method by doing three repetitions on 5 concentration series, 1 positive control and 1 negative control for two types of bacteria namely Propionibacterium acnes and Salmonella typhi. The results obtained from the Kruskal Wallis test on Propionibacterium acnes bacteria are Sig 0.028 < 0.05, and the results of the ANOVA test on Salmonella typhi bacteria from Sig = 0.000 < 0.05. And it is known in Propionibacterium acnes bacteria that 25% concentration inhibits 5.83 mm, 50% concentration inhibits 6.3 mm, 100% concentration inhibits 9.43 mm. And in Salmonella typhi bacteria that concentration is known that 25% concentration inhibits 9.73 mm, 50% concentration inhibits 9.43 mm, 100% concentration inhibits 11.57 mm. Based on the results of the study, it can be concluded that Sonneratia alba root infusa has antibacterial activity on Propionibacterium acnes and Salmonella typhii bacteria.
Antibacterial Activity Test Of Epazote Leaf Infusion (Dysphania ambrosioides L.) Against Escherichia coli Bacteria Carolina, Saroinsong F.; Montolalu, Friska M.; Tumbel, Silvana L.; Kanter, Jabes W.; Maarisit, Wilmar; pakingki, Priska
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 7 No. 2 (2024): Oktober 2024
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v7i2.458

Abstract

The most common health problem in Indonesia is bacterial infection. Dysphania ambrosioides L., also known as epazote leaves, is an herbal plant that has antimicrobial potential. This research was conducted to see at what concentration there is antibacterial activity of epazote leaf infusion Dysphania ambrosioides L. against Escherichia coli bacteria. This laboratory experimental study used a complete randomized design (RAL) research. Antibacterial activity testing of epazote leaves was carried out using the disc paper diffusion method with concentrations of 50%, 75%, and 100%. Epazote leaves are boiled in an infusion pan for 15 minutes, until the temperature reaches 90 degrees Celsius. Ampicillin positive control 10 ?g/disc. Based on the test results of secondary metabolites of positive epazote leaf infusion there are alkaloids, flavonoids, tannins, saponins, triterpenoids, and phenolics. The results of the study showed that infusion of epazote leaves inhibited Escherichia coli bacteria by diameter inhibition. Average at a concentration of 50% = 14.04 mm, 75% = 16.92 mm, 100% = 17.94 mm, which means that there is antibacterial activity of epazote leaf infusion against Escherichia coli bacteria.
Co-Authors Carolina, Saroinsong F. Christin, Andriany M. Friska Mery Montolalu Jabes Wolter Kanter Jeane Mongi Royke R. Palandi Silvana L. Tumbel Tombuku, Joke Luis Tulandi, Selvana Stien Wantah, Kezia T. Wilmar Maarisit