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Alfia Mujahra
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Humanities Economics, Econometrics & Finance Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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REVIEW: PENGARUH PERBEDAAN EKSIPIEN BINDER PADA TABLET PARACETAMOL TERHADAP WAKTU HANCUR DAN PELEPASAN OBAT Iqbal Nurwahid; Alfia Mujahra; Muhammad Zairullah; Riska Hidayah; Helsy Indarwati; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 3: Nopember 2024
Publisher : Bajang Institute

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Abstract

This study aims to evaluate and compare the effectiveness of natural and synthetic binders in paracetamol tablet formulation, focusing on sweet potato starch, pregelatinized cassava, and pectin as natural binders, as well as synthetic binders commonly used in the pharmaceutical industry. The method used in this study is a literature review, by collecting, analyzing, and synthesizing various relevant previous research results regarding the effect of binders on the physical properties of tablets and drug dissolution rates. Based on the literature analysis, it was found that natural binders, such as pregelatinized starch and pectin, showed comparable or even better results in several parameters, such as disintegration and drug release, compared to synthetic binders. Pregelatinized starch, in particular, showed a faster dissolution rate, while pectin gave good results in terms of tablet hardness and friability. In addition, natural binders are more economical and environmentally friendly than synthetic materials.
REVIEW JURNAL: EVALUASI UJI STABILITAS SEDIAAN CAIR ORAL Wima Triana; Alfia Mujahra; Nor Latifah
Jurnal Cakrawala Ilmiah Vol. 4 No. 11: Juli 2025
Publisher : Bajang Institute

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Abstract

Sediaan cair oral banyak digunakan dalam praktik farmasi karena kemudahan pemberian dan penerimaannya, terutama pada populasi pediatrik dan geriatri. Namun, kestabilan fisik, kimia, dan mikrobiologis sediaan ini sangat rentan terganggu oleh kondisi penyimpanan dan formulasi yang tidak optimal. Kajian ini bertujuan untuk mengevaluasi secara sistematis uji stabilitas sediaan cair oral berdasarkan studi literatur terkini dalam rentang 2018–2024. Metode yang digunakan adalah kajian pustaka terhadap jurnal ilmiah, pedoman ICH, serta laporan WHO dan BPOM. Hasil kajian menunjukkan bahwa penggunaan eksipien yang tepat, pemilihan kemasan pelindung seperti botol kaca amber, serta penerapan metode uji stabilitas jangka panjang dan dipercepat sangat menentukan mutu dan umur simpan sediaan. Selain itu, pemantauan parameter seperti viskositas, pH, potensi zat aktif, dan kontaminasi mikrobiologis merupakan langkah penting untuk menjamin kualitas produk. Penelitian ini menekankan pentingnya pendekatan Quality by Design (QbD) dan validasi metode analitik sebagai dasar pengembangan formulasi yang aman dan stabil. Kesimpulannya, strategi stabilisasi berbasis bukti sangat krusial dalam memastikan efektivitas dan keamanan sediaan cair oral di berbagai kondisi penyimpanan.
Co-Authors Helsy Indarwati Iqbal Nurwahid Muhammad Zairullah Nor Latifah Riska Hidayah Wima Triana