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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Applied Veterinary Science and Technology
Panjaitan, Novaria Sari Dewi
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Agriculture, Biological Sciences & Forestry Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Blumea balsamifera and Sargassum aquifolium extracts reduce fatty liver damage through lipid metabolism signalling pathways Widhiantara, I Gede; Wiradana, Putu Angga; Permatasari, Anak Agung Ayu Putri; Sari, Ni Kadek Yunita; Rosiana, I Wayan; Sandhika, I Made Gde Sudyadnyana; Panjaitan, Novaria Sari Dewi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and valuable research towards diagnosis, prognosis and treatment of dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.5697

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a condition marked by excessive fat accumulation in the liver and poses a significant health challenge. The leaves of Blumea balsamifera and Sargassum aquifolium have been reported to have anti-atherogenic effects. This study aims to determine the effectiveness of B. balsamifera extract (BBLE) and S. aquifolium extract (SAE) in preventing and treating liver fat accumulation in Wistar rats induced by a high-cholesterol diet through the expression of the AMP-activated protein kinase (AMPK)/ Sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor γ (PPARγ) pathway, and the leptin receptor. The experimental design of this study is laboratory-based, involving, 20 Wistar rats were fed a high-cholesterol diet over a period of 21 days. The rats were divided into four groups for the evaluation of BBLE and SAE effect: negative control (P0): induced with a high-cholesterol diet + distilled water, positive control (P1): induced with a high-cholesterol diet + simvastatin, P2: induced with a high-cholesterol diet + 4 mg/kg/bw BBLE, and P3: induced with a high-cholesterol diet + 4 mg/kg/bw BBLE and 4 mg/kg/bw SAE. The treatment duration extended over three months. Immunohistochemical analyses were performed on liver tissues to measure AMPK, SIRT1, PPARγ, and leptin receptor expression. The results indicated that leptin expression was lower in the BBLE+SAE group compared to the simvastatin group, and differences were significant between the BBLE and BBLE+SAE groups. No significant differences were noted in AMPK, SIRT1, and PPARγ expression between the simvastatin and BBLE+SAE groups (p≥0.05). In conclusion, BBLE and SAE effectively reduce liver lipid accumulation and enhance fat metabolism in hypercholesterolemic rats.
Kapasitas antioksidan, sitotoksisitas dan cemaran bakteri simplisia makroalga cokelat: Antioxidant capacity, cytotoxicity, and bacterial contamination of brown macroalgae simplicia Permatasari, Anak Agung Ayu Putri Permatasari; Permatasari, Anak Agung Ayu Putri; Wiradana, Putu Angga; Sari, Ni Kadek Yunita; Widhiantara, I Gede; Rosiana, I Wayan; Sandhika, I Made Gde Sudyadnyana; Sucipto, Teguh Hari; Panjaitan, Novaria Sari Dewi
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 27 No. 10 (2024): Jurnal Pengolahan Hasil Perikanan Indonesia 27(10)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v27i10.53930

Abstract

Brown algae are considered to be a source of antioxidants that can contribute to improving health. The purpose of this study was to determine the best combination of brown algae and solvent types based on the parameters of antioxidant capacity, toxicity to Vero cells, and bacterial contamination that affects brown algae simplicia during 30 d of storage. Brown algae, Sargassum aquifolium and Padina australis, were collected from Sanur Beach at the lowest point in the intertidal zone. Extraction was performed using three solvents: ethanol, methanol, and distilled water. The antioxidant capacity of the brown algae extracts was measured using the DPPH method. The brown algae extract, which showed antioxidant capacity and IC50 in the strong category, was used for cytotoxicity testing. Bacterial contamination testing was performed based on the simple storage time of brown algae for 30 d. The results showed that the combination of S. aquifolium and P. australis ethanol extract (ratio 1:10) had a yield percentage of 37.2% with an antioxidant capacity of 0.935±0.003 mg/L GAEAC and an IC50 value of 89.03 μg/mL (strong category). The combination of S. aquifolium and P. australis ethanol extracts had an IC50 value of 382.30 μg/mL (the weak category). Total plate count (TPC), Enterobacteriaceae, and coliforms increased with the storage time of simplicia for 30 days. These findings indicate that the combination of ethanol extracts of S. aquifolium and P. australis is a potential source of natural antioxidants.
A Literature Review on the Interactions Between Climate Change and Tuberculosis: Impacts on Epidemiology, Transmission, and Control Tan, Suriyani; Suyanto, Jipri; Panjaitan, Novaria Sari Dewi; Hidayat, Syarif; Fitriana, Fitriana; Sunarno, Sunarno; Lienggonegoro, Lisa Andriani
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2848

Abstract

Climate change is increasingly recognized as a contributor to public health challenges, including the spread of infectious diseases such as tuberculosis (TB). Environmental changes, such as rising temperatures, altered precipitation patterns, and extreme weather events, can directly and indirectly influence TB transmission dynamics. Additionally, climate change exacerbates socio-economic issues like poverty, food insecurity, and displacement, further increasing vulnerability to TB. Understanding the complex relationship between climate change and TB is crucial for developing effective prevention and control strategies. This literature review explores the relationship between climate change and TB, focusing on the impact of climatic factors on TB epidemiology, transmission, and control measures. A systematic evaluation of peer-reviewed studies was conducted using databases such as Science Direct, PubMed, DOAJ, and Google Scholar. Research on climatic factors (e.g., temperature, humidity, extreme weather events) and their effects on TB transmission, as well as the socio-economic consequences of climate change, was analyzed. The PICOS framework and PRISMA guidelines were applied to ensure a comprehensive review. The findings reveal that elevated temperatures and humidity can enhance the survival and spread of Mycobacterium tuberculosis, potentially increasing TB transmission rates. Extreme weather events, such as floods and droughts, disrupt healthcare services and create overcrowded living conditions, fostering TB outbreaks. Socio-economic factors, including poverty, starvation, and migration, further heighten TB risks. Climate change-induced disruptions to health infrastructure, particularly in low- and middle-income countries, hinder TB diagnosis, treatment, and control efforts. However, there is a lack of long-term studies assessing the cumulative effects of climate change on TB. This review highlights the urgent need for interdisciplinary approaches to address the dual challenges of climate change and TB. Effective TB control programs must integrate climate adaptation and resilience strategies. Policymakers should prioritize climate-informed TB initiatives, enhance monitoring systems, and support further research to address gaps in understanding the long-term impacts of climate change on TB.
Isolation and Molecular Identification of Endophytic Fungi Associated with Brown Algae for Inhibiting Escherichia coli ESBL Wiradana, Putu Angga; Permatasari , Anak Agung Ayu Putri; Sari, Ni Kadek Yunita; Widhiantara, I Gede; Sandhika, I Made Gde Sudyadnyana; Waruwu, Ernawati; Fimaputra, Jatu Maranatha; Panjaitan, Novaria Sari Dewi; Putri, Fadillaisyia Riandani; Ansori, Arif Nur Muhammad

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Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: The marine environment is the main source of research on natural products in the future. In addition, marine microorganisms have been identified as a natural source capable of developing new antibiotic compounds, including controlling urinary tract infections caused by Escherichia coli ESBL. Purpose: This study aims to isolate, select, and test the potential of brown macroalgae endophytic fungi (Phaeophyceae) collected from the coastal waters of Sanur, Bali Province. Methods: Three types of brown algae were collected from Sanur Beach and their endophytic fungi were isolated using PDA media. Antibacterial activ
Co-Authors Adi Sofyan Ansori, Muhammad Fimaputra, Jatu Maranatha Fitriana Fitriana I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Lienggonegoro, Lisa Andriani NI KADEK YUNITA SARI Permatasari , Anak Agung Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari Putri, Fadillaisyia Riandani Putu Angga Wiradana Sunarno Sunarno Suriyani Tan, Suriyani Suyanto, Jipri Syarif Hidayat Teguh Hari Sucipto, Teguh Hari Waruwu, Ernawati