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All Journal International Journal of Public Health Science (IJPHS) Majalah Farmaseutik
Pangeran, Paryany
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Health Professions Medicine & Pharmacology

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Evaluasi Potensi Penghambatan Ekstrak Etil Asetat Isolat Fungi Indonesia terhadap Staphylocaccus aureus ATCC 25923 dan Escherichia coli ATCC 25922 Pangeran, Paryany; Purwantini, Indah; Chrisnayanti, Evita
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.97584

Abstract

Indonesia dengan iklim tropis menjadi tempat ideal bagi pertumbuhan fungi yang diketahui menjadi salah satu sumber senyawa bioaktif, termasuk antibiotik. Badan Riset dan Inovasi Nasional (BRIN) memiliki koleksi fungi yang diisolasi dari berbagai daerah di Indonesia dari tahun 2015 hingga 2020 yang berpotensi besar sebagai sumber senyawa antibakteri baru. Skrining aktivitas penghambatan terhadap Staphylococcus aureus dan Escherichia coli telah dilakukan untuk ekstrak etil asetat isolat fungi tersebut dengan metode difusi cakram. Sepuluh dari 22 ekstrak menunjukkan penghambatan terhadap Staphylococcus aureus dan hambatan terbesar dihasilkan oleh ekstrak F4-20 dengan diameter zona penghambatan 14,773±1,387 mm. Satu ekstrak, yaitu F4-7 menunjukkan penghambatan terhadap Escherichia coli dengan diameter zona penghambatan 9,939±0,578 mm. KLT Bioautografi dilakukan terhadap ekstrak-ekstrak yang mampu menghambat pertumbuhan kedua bakteri uji. Berdasarkan hasil KLT bioautografi diperkirakan terdapat 6 senyawa antibakteri yaitu senyawa dengan Rf 0,63 dan 0,7 (F4-2), Rf 0,46 (F4-3), Rf 0,77 (F4-11), Rf 0,43 (F4-15), Rf 0,68 (F4-20). Senyawa dengan Rf 0,7 (F4-2) teridentifikasi sebagai senyawa diterpen berdasarkan visualisasi menggunakan reagen anisaldehid-asam sulfat.
Prediction of pulmonary tuberculosis incidence based on epidemiological triad as a preventive measure Sutriyawan, Agung; Anri, Anri; Imbar, Andri W. J.; Natsir, Ramdhani M.; Pangeran, Paryany; Akbar, Hairil
International Journal of Public Health Science (IJPHS) Vol 12, No 3: September 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i3.22792

Abstract

The decline in the incidence of tuberculosis to date still looks very slow, although some efforts have been made to improve case identification and treatment adherence. This study aimed to assess the factors associated with the incidence of pulmonary tuberculosis. The research design for this study was observational analytical with a cross-sectional design. A total of 830 people suspected of tuberculosis, aged over 15 years, and not drug-resistant were selected by simple random sampling. Overall, 59.9% of people are infected with pulmonary tuberculosis. There was a significant association between age (p=0.002) (OR=1.69; 95% CI: 1.22, 2.35), smoking behavior (p=0.000) (OR=2.3; 95% CI: 1.67, 3.30), temperature (p=0.000) (OR=4.2; 95% CI: 2.84, 6.47), humidity (p=0.000) (OR=6.7; 95% CI: 4.69, 9.77), lighting (p=0.000) (OR=4.174; 95% CI: 2.94, 5.92) and incidence of pulmonary tuberculosis. The study showed that tuberculosis was more common among productive age and smokers living in homes with unqualified temperature, humidity, and lighting. Room humidity is the most associated factor with the incidence of pulmonary tuberculosis. Therefore, education on the importance of paying attention to the physical environment of the house to avoid pulmonary tuberculosis is highly recommended.
Co-Authors Akbar, Hairil Anri, Anri Evita Chrisnayanti Imbar, Andri W. J. Indah Purwantini Natsir, Ramdhani M Sutriyawan, Agung