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All Journal Agrintech: Jurnal Teknologi Pangan dan Hasil Pertanian IJOEP : International Journal of Ecophysiology Jurnal Akademika Kimia JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Journal of Innovative and Creativity Jurnal Akademika Kimia
Taufik, Muhammad
Chemistry Department Mathematics And Natural Science Faculty Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Social Sciences Other

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Phytochemical Screening, Cream Formulation, and Antibacterial Activity of Cyanthillium cinereum (L.) H. Rob. Leaf Ethanol Extract against Staphylococcus aureus Muhammad Taufik; Mariany Razali; Muharni Saputri; Nurmala Sari; Mia Ramayani Damanik; Siti Fathiyah Mawaddah; Putra Penyabar Gulo; Nazwa Amalia Apriani; Citra Marisa
Journal of Chemical Natural Resources Vol. 8 No. 2 (2026): Journal of Chemical Natural Resources (JCNaR)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jcnar.v8i2.27332

Abstract

Cyanthillium cinereum (L.) H. Rob. contains secondary metabolites with potential antibacterial activity. This study performed qualitative phytochemical screening of the leaf ethanol extract, formulated topical creams containing 0.75% (F1), 1.5% (F2), and 3% (F3) extract, and evaluated preliminary physical stability and antibacterial activity against Staphylococcus aureus ATCC 25923. Qualitative screening detected alkaloids, steroids, saponins, flavonoids, tannins, glycosides, and phenolic compounds. The creams were homogeneous; mean pH values ranged from 6.22 to 6.45 before cycling and from 6.00 to 6.05 after cycling. Antibacterial responses increased with concentration. F3 produced the greatest response among the creams (19.07 ± 0.45 mm, n = 3), while the blank base showed no inhibition; the corresponding unformulated 3% extract produced 19.23 ± 0.42 mm. Two-way ANOVA showed significant effects of preparation type (p < 0.001), concentration (p < 0.001), and their interaction (p = 0.003). The E3-F3 difference was not significant by Tukey HSD (p = 0.996), but this does not establish statistical equivalence. These findings indicate that an antibacterial response remains measurable after incorporation into a cream matrix and support further investigation of the 3% formulation.
Co-Authors Adelia Y. P. Hasibuan Aldy Fardiansyah Alensia Estetika Manalu Andriayani Andriayani Citra Marisa Dafni Mawar Tarigan Desi Ardilla Elsa Priskila Eva Dasopang Harry Agusnar Helen Gandaria Situmorang Hendy Syahputra Siregar Henny Dumarta Hutapea Mariany Razali Mariany Razali Mariany Razali May Rifani Br Ginting Mia Ramayani Damanik Muhammad Iqbal Afritario Muhammad Thamrin Muharni Saputri Nazwa Amalia Apriani Nurmala Sari Nurmala Sari Putra Penyabar Gulo R.A. Fani Miranda Rika Silvany Rini Hardiyanti Sembiring, Helmina Br. Siti Fathiyah Mawaddah Supran Hidayat Sihotang Yendri Nofira Yessi Febriani Zabdan Ahmad Arrazi Zul Alfian