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All Journal Indonesian Journal of Chemistry Jurnal Pengabdian Inovasi Masyarakat Indonesia
Nursofia, Baiq Ike
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Education Social Sciences Other

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One-Pot Synthesis and In Vitro Studies of Calix[4]-2-methylresorcinarene Derivatives as Antimalarial Agents Against Plasmodium falciparum Chloroquine-Resistant Strain FCR-3 Nursofia, Baiq Ike; Kurniawan, Yehezkiel Steven; Jumina, Jumina; Pranowo, Harno Dwi; Sholikhah, Eti Nurwening; Julianus, Jeffry; Wibowo, Susalit Setya; Fatimi, Hana Anisa; Priastomo, Yoga; Priyangga, Krisfian Tata Aneka
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.94885

Abstract

Malaria is an endemic disease in Indonesia caused by infection from the Plasmodium parasite. Recently, antimalarial resistance significantly contributed to the decline in the cure rate of malaria sufferers. In this work, three calix[4]resorcinarenes have been synthesized from 2-methylresorcinol and different benzaldehyde derivatives, i.e., 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, and 4-dimethylaminobenzaldehyde through the one-pot synthesis procedure. The calix[4]resorcinarenes synthesis was done through a cyclo-condensation reaction by using HCl 37% as the catalyst and ethanol as the solvent in an one-pot reaction. The structures of the synthesized products were confirmed using Fourier transform infrared, proton-nuclear magnetic resonance, and liquid chromatography-mass spectrometry techniques. The antimalarial activity assay was evaluated against the Plasmodium falciparum FCR-3 strain through an in vitro study. Three synthesized compounds, i.e., C-4-chlorophenylcalix[4]-2-methylresorcinarene, C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene have been successfully synthesized in up to 97% yield. The C-4-chlorophenylcalix[4]-2-methylresorcinerene exhibited the most potent antimalarial activity with a half-maximal inhibitory concentration (IC50) value of 2.66 µM against P. falciparum FCR-3 while the C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene gave the IC50 values of 23.63 and 13.82 µM, respectively. From the results, it could be concluded that the antimalarial activity of calix[4]-2-methylresorcinarenes was influenced by the type of substituent of aromatic rings at the para position.
Pelatihan dan Penerapan Teknologi Filtrasi Ramah Lingkungan untuk Pengolahan Limbah Pewarna Songket di UMKM Ungga Creative, Lombok Tengah Septiyana, Maulida; Putri, Baiq Yusmiar Aulia; Tsani, M. Khairul; Ningsih, Apriliya; Ramdhani, Restu Agung; Nursofia, Baiq Ike; Ningsih, Baiq Nila Sari; Dharmayani, Ni Komang Tri; Ulfa, Maria; Yuanita, Emmy; Budiana, Irwan
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 4 No. 2b (2025): Edisi khusus Dies Natalis Universitas Mataram
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/4mhjgv27

Abstract

Usaha Mikro, Kecil, dan Menengah (UMKM) Ungga Creative yang berlokasi di Desa Ungga, Lombok Tengah, merupakan UMKM yang berfokus pada produksi kain songket, mulai dari proses pewarnaan benang hingga tahap penenunan. UMKM ini menghadapi permasalahan berupa limbah cair hasil pewarnaan yang berpotensi mencemari lingkungan sekaligus meningkatkan biaya produksi. Oleh karena itu, kegiatan pengabdian ini dilaksanakan untuk memberikan solusi melalui penerapan teknologi pengolahan limbah tekstil berbasis pengendapan tawas dan filtrasi sederhana dengan memanfaatkan media berupa pasir, kain perca, zeolit, dan serabut kelapa. Metode kegiatan Pengabdian kepada Masyarakat ini meliputi penyuluhan mengenai dampak limbah tekstil, pelatihan praktis, serta pendampingan implementasi teknologi. Hasil kegiatan menunjukkan bahwa masyarakat menjadi lebih memahami bahaya limbah pewarna tekstil apabila terpapar ke lingkungan. Selain itu, teknologi filtrasi terbukti dapat diaplikasikan secara langsung pada skala UMKM dan mampu menurunkan intensitas warna serta tingkat kekeruhan limbah, sehingga air hasil olahan dapat digunakan kembali dalam proses pewarnaan. Masyarakat mitra juga mengalami peningkatan pengetahuan dan keterampilan dalam pengelolaan limbah tekstil. Selain memberikan manfaat ekonomi berupa efisiensi penggunaan air, kegiatan ini turut mendukung keberlanjutan usaha dan berkontribusi pada pencapaianSDG 6 (air bersih dan sanitasi layak), SDG 12 (konsumsi dan produksi yang bertanggung jawab), serta SDG 13(penanganan perubahan iklim).
Co-Authors Budiana, Irwan Emmy Yuanita Eti Nurwening Sholikhah Fatimi, Hana Anisa Harno Dwi Pranowo Jeffry Julianus Jumina Jumina Kurniawan, Yehezkiel Steven Maria Ulfa Maulida Septiyana Ningsih, Apriliya Ningsih, Baiq Nila Sari Priastomo, Yoga Priyangga, Krisfian Tata Aneka Putri, Baiq Yusmiar Aulia Ramdhani, Restu Agung Tri Dharmayani, Ni Komang Tsani, M. Khairul Wibowo, Susalit Setya