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All Journal Indonesian Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) JIFI (Jurnal Ilmiah Farmasi Imelda) Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian
Fatimi, Hana Anisa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari; Larasati, Rizky Dwi; Ramadhana, Irma Hazira Awalinda; Putranti, Inneke Nurul Dwi; Kholifatuzzahroh; Shafwa, Mayra
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): Vol. 8 No. 1, September Tahun 2024
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1767

Abstract

The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Several tests were conducted to evaluate the preparation of paracetamol syrup, namely organoleptic test, content determination test, pH test, viscosity test, and specific gravity test. Data was obtained from relevant literature sources such as Google Scholar, ResearchgateNet and Science direct and obtained 10 journals that met the criteria. The use of different cosolvents in syrup will produce different physical values. Paracetamol syrup with PEG 400 and glycerin cosolvents had greater viscosity than paracetamol syrup with propylene glycol and Ryoto sugar ester cosolvents. Paracetamol syrup with PEG 400 and glycerin cosolvents had a greater specific gravity than paracetamol syrup with propylene glycol cosolvents and Ryoto sugar ester surfactant. Based on the results of a review of 10 journal articles, it appears that the use of different cosolvents in paracetamol syrup preparations can modify the preparation and affect the level of stability of the resulting syrup preparation.
Optimization of 3,4-Dimethoxychalcone and Rutin Containing Gel with Simplex Lattice Design and In Vitro-In Vivo Test as a Sunscreen Fatimi, Hana Anisa; Zulkarnain, Abdul Karim; Laksitorini, Marlyn Dian
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

3,4-Dimethoxychalcone and rutin, a flavonoid that contains chromophore groups, can absorb UV light and thus can be developed as a sunscreen. The objective of this study was to determine the optimum formula of 3,4-dimethoxychalcone and rutin containing gel, evaluate its physical stability, and activity of 3,4-dimethoxychalcone and rutin gel as a sunscreen through in vitro and in vivo tests. HPMC, CMC-Na, and methylcellulose were formulated into a gel base to obtain good adhesion and a clear appearance gel. Simplex Lattice Design (SLD) with Design Expert software version 10 was utilized to determine the optimum gel formulation. UVA-PF protection, photostability with transpore method, and acute dermal irritation test were performed to evaluate sunscreen activity of 3,4-dimethoxychalcone and rutin gel. The data were analyzed using SPSS version 25. The results showed that the optimum formula for 3,4-dimethoxychalcone-rutin gel consisted of 1.5% HPMC, 1.8% CMC-Na and 0.6% methylcellulose, which showed a pH of 6.96, viscosity of 89.10 dpa.s, and spreadability of 16.30 cm2. The pH, viscosity, and spreadability of base and 3,4-dimethoxychalcone- rutin gel was stable for 4 weeks of storage. The UVA-PF value is 6.48 which according to the FDA is included in the category of a two star (**) sunscreen label. The sunscreen did not exhibit a shift in wavelength after 6 hours of irradiation. Based on the primary irritation test, 3,4-dimethoxychalcone- rutin sunscreen produced zero (0) erythema and edema index. Thus, it did not cause irritation to the skin of experimental animals. Therefore, the gel containing 3,4-dimethoxychalcone and rutin had potential as a sunscreen product based on in vitro-in vivo tests and was safe on animal skin.
FORMULATION AND IN VITRO PENETRATION TESTING OF NUTMEG SEED OIL (Myristica fragrans Houtt.) NANOEMULGEL Lailah, Nashfiatun Nur; Syaputri, Fauziah Ningrum; Larasati, Rizky Dwi; Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1635

Abstract

Nutmeg seed oil has a low absorption time and is unstable during storage; therefore, so to facilitate this it is made in a nanoemulgel form because it can increase contact time and increase drug penetration into the skin. This study aimed to determine the effect of variations in nutmeg seed oil concentration on the physical characteristics and penetration rate of nanoemulgel preparations. Nanoemulgel was made by mixing the nanoemulsion phase into a gel base with oil concentrations of 4.5%, 5%, and 5.5%. The nanoemulsion physical characteristics results are 90.7–91.1% for the turbidimetry test, 453–516 nm for particle size, 42.4–48.6 mV for the zeta potential test, 6.46–6.66 for the pH test, and O/W for nanoemulsion type. Physical characteristics included organoleptic tests, homogeneity, pH, adhesive power, spreadability, viscosity, and rheology. The penetration rate was determined using the Franz diffusion-cell method. The results showed that the nanoemulgel preparation was white in color and had a characteristic smell of nutmeg oil, a semisolid, homogeneous texture, skin pH of 4.5–6.5, spreadability met the range of 5–7 cm, adhesion of >4 seconds, viscosity of 4000–50000 cPs, and pseudoplastic flow properties. The best formulas are found in Formulas 1 and 2 because the stability test meets the requirements for good physical characteristics. Variations in the concentration of nutmeg oil did not show any influence on the penetration rate, with the flux values ??obtained for each formula being F1 0.0117 mg/cm2hour-1, F2 0.0126 mg/cm2hour-11, and F3 0.0246 mg/cm2hour-1.
One-Pot Synthesis and In Vitro Studies of Calix[4]-2-methylresorcinarene Derivatives as Antimalarial Agents Against Plasmodium falciparum Chloroquine-Resistant Strain FCR-3 Nursofia, Baiq Ike; Kurniawan, Yehezkiel Steven; Jumina, Jumina; Pranowo, Harno Dwi; Sholikhah, Eti Nurwening; Julianus, Jeffry; Wibowo, Susalit Setya; Fatimi, Hana Anisa; Priastomo, Yoga; Priyangga, Krisfian Tata Aneka
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.94885

Abstract

Malaria is an endemic disease in Indonesia caused by infection from the Plasmodium parasite. Recently, antimalarial resistance significantly contributed to the decline in the cure rate of malaria sufferers. In this work, three calix[4]resorcinarenes have been synthesized from 2-methylresorcinol and different benzaldehyde derivatives, i.e., 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, and 4-dimethylaminobenzaldehyde through the one-pot synthesis procedure. The calix[4]resorcinarenes synthesis was done through a cyclo-condensation reaction by using HCl 37% as the catalyst and ethanol as the solvent in an one-pot reaction. The structures of the synthesized products were confirmed using Fourier transform infrared, proton-nuclear magnetic resonance, and liquid chromatography-mass spectrometry techniques. The antimalarial activity assay was evaluated against the Plasmodium falciparum FCR-3 strain through an in vitro study. Three synthesized compounds, i.e., C-4-chlorophenylcalix[4]-2-methylresorcinarene, C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene have been successfully synthesized in up to 97% yield. The C-4-chlorophenylcalix[4]-2-methylresorcinerene exhibited the most potent antimalarial activity with a half-maximal inhibitory concentration (IC50) value of 2.66 µM against P. falciparum FCR-3 while the C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene gave the IC50 values of 23.63 and 13.82 µM, respectively. From the results, it could be concluded that the antimalarial activity of calix[4]-2-methylresorcinarenes was influenced by the type of substituent of aromatic rings at the para position.
Edukasi Bahaya Kosmetik Ilegal di Desa Plesungan Kecamatan Gondangrejo Kabupaten Karanganyar Jawa Tengah: Education on the Danger of Illegal Cosmetics in Plesungan Village, Gondangrejo District, Karanganyar District, Central Java Puspitasari, Lia; Larasati, Rizky Dwi; Astuti, Rini Budi; Prabowo, Imam; Sari, Putri Kharisma Novita; Fatimi, Hana Anisa; Nugraha, Akbar Eka; Pribadi, Fitrawan Hernuza
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8449

Abstract

Cosmetics are one of the products to improve appearance which are increasingly widely used in Indonesia. However, the large number of cosmetic uses is not in line with the quality. In recent years, Badan Pengawas Obat dan Makanan (BPOM) has noticed an increase in the spread of illegal cosmetics in Indonesia. Educational videos are one practical medium that can be used to promote the dangers of illicit cosmetics. This community service program aims to increase public understanding of the dangers of illegal cosmetics circulating on the market. Community service activities are created by creating educational materials and videos that are disseminated to the public directly or via social media. So that through this educational video, the public can understand it well. The activities then looked at the public's initial level of understanding of the dangers of cosmetics by conducting a pre-test. After that, the videos and materials that had been prepared were shown, and then the public's knowledge increased through the post-test. From the results of the pre-test and post-test, it was found that public understanding of the dangers of cosmetics increased by 17.1%. So it can be concluded that this service activity successfully educated the community.
Dragon Fruit Peels Waste as Cosmetic: An Overview Fatimi, Hana Anisa; Ramadhana, Irma Hazira Awalinda; Purnama, Magnifico Fatta
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2464

Abstract

Dragon fruit peels (Hylocereus polyrhizus) have various potential as a base ingredient in eco-friendly cosmetic products. This study focused on evaluating the bioactive properties of dragon fruit peels, finding that the compounds contained therein are more effective in counteracting free radicals than the flesh of the fruit. Data collection techniques were carried out by literature study and digital information search with the target objectives in the form of literature study (literature review) searching for information from relevant literature sources for two week in November - December 2024 by searching >30 references from Google Scholar, ResearchgateNet and Sciencedirect, Sinta, MDPI, Pubmed. As well as, official websites in the range of 2014-2024. Literature study was conducted by identifying problems regarding the content of different formulations. The method was through a qualitative approach, which is descriptive research and tends to use analysis. Dragon fruit peel extract showed significant activity in preventing skin damage caused by UV rays and pollution. This innovation not only provides a solution for agro-industrial waste reduction, but also creates sustainable cosmetic products with high economic value. This waste utilization supports the consumer trend towards products based on natural and environmentally friendly ingredients From this review, dragon fruit peels have a great opportunity to be used as an active ingredient in various types of cosmetic products, such as moisturizers, serums, creams, and face masks, with a positive impact on skin health and the environment.
Co-Authors Abdul Karim Zulkarnain Astuti, Rini Budi Eti Nurwening Sholikhah Harno Dwi Pranowo Imam Prabowo, Imam Jeffry Julianus Jumina Jumina Kholifatuzzahroh Kurniawan, Yehezkiel Steven Lailah, Nashfiatun Nur Larasati, Rizky Dwi Lia Puspitasari Manurung, Devi Yanthre Sari Marlyn Dian Laksitorini, Marlyn Dian Nugraha, Akbar Eka Nursofia, Baiq Ike Priastomo, Yoga Pribadi, Fitrawan Hernuza Priyangga, Krisfian Tata Aneka Purnama, Magnifico Fatta Putranti, Inneke Nurul Dwi Ramadhana, Irma Hazira Awalinda Sari, Putri Kharisma Novita Shafwa, Mayra Syaputri, Fauziah Ningrum Wibowo, Susalit Setya