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All Journal Indonesian Journal of Chemistry Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Molekul: Jurnal Ilmiah Kimia
Priastomo, Yoga
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology

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One-Pot Synthesis and In Vitro Studies of Calix[4]-2-methylresorcinarene Derivatives as Antimalarial Agents Against Plasmodium falciparum Chloroquine-Resistant Strain FCR-3 Nursofia, Baiq Ike; Kurniawan, Yehezkiel Steven; Jumina, Jumina; Pranowo, Harno Dwi; Sholikhah, Eti Nurwening; Julianus, Jeffry; Wibowo, Susalit Setya; Fatimi, Hana Anisa; Priastomo, Yoga; Priyangga, Krisfian Tata Aneka
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.94885

Abstract

Malaria is an endemic disease in Indonesia caused by infection from the Plasmodium parasite. Recently, antimalarial resistance significantly contributed to the decline in the cure rate of malaria sufferers. In this work, three calix[4]resorcinarenes have been synthesized from 2-methylresorcinol and different benzaldehyde derivatives, i.e., 4-chlorobenzaldehyde, 4-methoxybenzaldehyde, and 4-dimethylaminobenzaldehyde through the one-pot synthesis procedure. The calix[4]resorcinarenes synthesis was done through a cyclo-condensation reaction by using HCl 37% as the catalyst and ethanol as the solvent in an one-pot reaction. The structures of the synthesized products were confirmed using Fourier transform infrared, proton-nuclear magnetic resonance, and liquid chromatography-mass spectrometry techniques. The antimalarial activity assay was evaluated against the Plasmodium falciparum FCR-3 strain through an in vitro study. Three synthesized compounds, i.e., C-4-chlorophenylcalix[4]-2-methylresorcinarene, C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene have been successfully synthesized in up to 97% yield. The C-4-chlorophenylcalix[4]-2-methylresorcinerene exhibited the most potent antimalarial activity with a half-maximal inhibitory concentration (IC50) value of 2.66 µM against P. falciparum FCR-3 while the C-4-methoxyphenylcalix[4]-2-methylresorcinarene and C-4-dimethylaminophenylcalix[4]-2-methylresorcinarene gave the IC50 values of 23.63 and 13.82 µM, respectively. From the results, it could be concluded that the antimalarial activity of calix[4]-2-methylresorcinarenes was influenced by the type of substituent of aromatic rings at the para position.
Synthesis and Antibacterial Activity of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline Nofiyanti, Estin; Wahyuningsih, Tutik Dwi; BTAG, Noer Laelly; Anwar, Chairil; Nurjanah, Novi; Salman, Nurcholis; Priastomo, Yoga
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.5618

Abstract

ABSTRACT. Compound of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline was synthesized by cycloaddition reaction. The structure of the product was chracterized by FTIR, 1H-NMR and 13C-NMR spectrometers. The pyrazoline was screened for antibacterial activity using agar diffusion method against Staphylococcus aureus, Bacillus cereus, Bacillus subtillis, Shigella flexnerri, and Escherichia coli. The pyrazoline had been synthesized from chalcone with phenylhydrazine to give 52.90% yield. Antibacterial screening showed that pyrazoline was active against selected gram positive bacteria. The pyrazoline was found to exhibits an antibacterial activity and its zone of inhibition/concentration against S. aureus (8.75/300), B. cereus (7.75/1000), B. subtillis (6.50/1000), and E. coli (3.50/300). The result showed that pyrazoline which was subtituted with chloro and methoxy, was able to posse broad spectrum of the tested pathogenic bacteria. Keywords: chalcone, pyrazoline, antibacterial
Pendampingan Manajemen Kewirausahaan Melalui Pembuatan Eco Enzim dan Sabun Herbal Ramah Lingkungan dengan Memanfaatkan Limbah Rumah Tangga Rohaeti, Eli; Rohmawati, Dini; Priastomo, Yoga; Afikah, Adilah; Sasmi, Weni Tri; Goni, Nur Abdul; Joronavalona, Rasamimanana; Dianti, Sekar Paramitha Rizqy
Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Vol. 9 No. 2 (2025): Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA
Publisher : Yogyakarta State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jpmmp.v9i2.78766

Abstract

The urgency of the Community Service Activities (PPM) that will be conducted is in accordance with the challenges faced by partners in the development of professional human resources for Advanced Indonesia. Specifically, family welfare requires further development through the provision of skills to women who are economically unproductive. The entrepreneurial spirit of women in the city of Yogyakarta, particularly mothers in Kampung Kuncen RT 21 RW 05, Pakuncen Village, Wirobrajan District, Yogyakarta City, is still relatively low. They require training to achieve independence, particularly in the field of green economy, in order to establish prosperous families by prioritizing environmental sustainability. The issue of domestic waste, which is the leftover vegetables and fruits produced by households, is also urgent. This waste is being disposed of in landfills or residential areas, which will contaminate the surrounding environment. Additionally, Yogyakarta is presently experiencing a waste disposal emergency. In reality, household waste, including unspent vegetables and fruits, can be repurposed as eco enzyme materials. These materials can be employed as air fresheners, cleansing agents, and as supplementary ingredients in the production of herbal soap. Furthermore, soap can be produced from cooking oil residue. The urgency of Community Service activities, particularly the issue of managing household waste (environmental aspect) and the issue of enhancing the abilities of women in assisting the family economy (economic aspect). Mentoring activities for the production of botanical soap and eco enzymes are proposed as a solution to these issues. The objective of the PPM activities is to enhance the comprehension and capabilities of women in the field of entrepreneurship by providing them with independence training through mentoring in the production of environmentally friendly herbal soap. This soap is made by utilizing used cooking oil as the primary ingredient and fruit and vegetable waste as raw materials for the production of eco enzymes, which are used as soap additives. PPM activities are intended to enhance Key Performance Indicator (KPI) 3 UNY, which refers to lecturers who engage in activities outside of the classroom. Furthermore, four students who are participating in this PPM activity have expertise in the preparation and management of a PPM activity. This will enhance the achievement of KPI 7, which is a collaborative and participatory class.
Co-Authors Afikah, Adilah BTAG, Noer Laelly Chairil Anwar Dianti, Sekar Paramitha Rizqy Dini Rohmawati Eli Rohaeti Estin Nofiyanti Eti Nurwening Sholikhah Fatimi, Hana Anisa Goni, Nur Abdul Harno Dwi Pranowo Jeffry Julianus Joronavalona, Rasamimanana Jumina Jumina Kurniawan, Yehezkiel Steven Nurjanah, Novi Nursofia, Baiq Ike Priyangga, Krisfian Tata Aneka Salman, Nurcholis Sasmi, Weni Tri Tutik Dwi Wahyuningsih Wibowo, Susalit Setya