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All Journal JURNAL TAHURI Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat Abdi Geomedisains Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian
Ramadhan, Muhammad Reza
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Edukasi Penanganan Limbah Obat dan Limbah B3 Di Kelompok PKK Gonggangan, Bolon, Colomadu, Karanganyar Fauzi, Ahmad; Saifudin, Azis; Hidayatullah, Muhammad Haqqi; Ramadhan, Muhammad Reza; Kholifatul Hakimah, Wafiq; Mufidah Maulina, Fariha
Abdi Geomedisains Vol. 5, No. 2, December 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/abdigeomedisains.v5i2.6968

Abstract

The management of hazardous and toxic waste (B3) and household pharmaceutical waste is a critical issue due to its adverse effects on human health and the environment. B3 waste, such as used batteries, light bulbs, spent oil, and aerosol cans, poses a significant risk of contaminating soil, water, and air if not properly managed. Pharmaceutical waste, including expired or damaged medications, also has the potential to harm public health. Improper disposal can lead to pollution, causing acute health problems such as neurological damage and respiratory disorders, as well as long-term risks such as cancer and genetic mutations. To address this issue, an community program was conducted for the community in Dusun Gonggangan, Bolon, Colomadu, Karanganyar, involving the local women's community group (PKK). The method employed consisted of education through presentations and interactive Q&A sessions. The materials covered waste identification, segregation, storage, and disposal according to proper waste management standards. Interactive discussions encouraged active community participation to understand and adopt responsible household waste management practices. The results showed an increase in community awareness regarding the proper management of B3 and household pharmaceutical waste. The implementation of appropriate waste management practices is expected to mitigate the negative impacts of waste on health and the environment. Thus, effective waste management contributes to improved public health and supports environmental sustainability and ecosystem preservation.
Pemberdayaan Masyarakat Melalui Sosialisasi Formulary TOGA di Desa Dukuh Karanganyar : Community Empowerment Through the Socialization of The TOGA Formulary in Dukuh Village Karanganyar Amani, Khalisa Dhiya; Rahmadhani, Ajeng; Damayanti, Alida Rahmalia; Adha, Dinda Caesaria Adha; Sari, Aisah Kensar Nawang Wulan; Azizah, Rauhillah Nurul; Ramadhan, Muhammad Reza; Niam, Muhammad Labib Qotrun; Al Fawwaz, Zulfa Kamila; Nasywa, Nabila Luthfiana; Persada, Tashila Zahra; Utama, Haya Nabilah; Rahmallia, Ega; Sukamto, Dandi Febrian; Candrika, Nasha Lulut; Arifah Sri Wahyuni
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 4 No. 3 (2024): September
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak: Tanaman Obat Keluarga (TOGA) merupakan tanaman yang ada di sekitar lingkungan kita yang dapat dimanfaatkan sebagai obat karena memiliki zat aktif yang berfungsi untuk mencegah dan mengobati penyakit, baik penyakit yang disebabkan oleh perubahan cuaca, maupun paparan virus dan bakteri serta mencegah penyakit dengan memperkuat sistem imun tubuh. Pemanfaatan TOGA di Desa Dukuh dinilai kurang optimal karena rendahnya pemahaman masyarakat terhadap TOGA. Kegiatan sosialisasi program dengan metode penyuluhan dengan mengenalkan formularium TOGA dilakukan untuk meningkatkan pemahaman masyarakat terkait tanaman obat keluarga. Metode ceramah secara interaktif dilakukan supaya mudah dipahami oleh peserta. Kegiatan dihadiri oleh 28 peserta dari kalangan ibu – ibu PKK dan beberapa warga desa. Untuk menilai keefektifan dari sosialiasi, maka dilakukan pretest dan posttest terkait jenis dan manfaat TOGA serta penyakit umum. Hasil menunjukkan bahwa sosialisasi ini mampu meningkatkan pemahaman masyarakat terkait tanaman obat keluarga (TOGA). Peningkatan pemahaman masyarakat terkait jenis, manfaat TOGA dan penyakit yang bisa diobati dengan TOGA adalah 15,21%.   Abstract: Family Medicinal Plants (TOGA) are plants found in our surroundings that can be utilized as medicine because they contain active substances that function to prevent and treat diseases, whether caused by weather changes, exposure to viruses and bacteria, or to prevent diseases by strengthening the body's immune system. The utilization of TOGA in Dukuh Village is considered suboptimal due to the low understanding of the community regarding TOGA. The program socialization activities using the extension method by introducing the TOGA formulary were carried out to enhance the community's understanding of family medicinal plants. The interactive lecture method was used to ensure it was easily understood by the participants. The event was attended by 28 participants. To assess the effectiveness of the socialization, a pretest and post-test were conducted regarding the types and benefits of TOGA as well as common diseases. The results showed that this socialization was able to increase the community's understanding of family medicinal plants. (TOGA). The increase in public understanding regarding the types, benefits of TOGA, and diseases that can be treated with TOGA is 15.21%.
Pendampingan Pembangunan Konservasi Tanaman Obat Keluarga (TOGA) Guna Menciptakan Desa Maju di Desa Dukuh Karanganyar Fawwaz, Zulfa Kamila Al; Nasywa, Nabila Luthfiana; Persada, Tashila Zahra; Utama, Haya Nabilah; Rahmallia, Ega; Sukamto, Dandi Febrian; Chandrika, Nasha Lulut; Amani, Khalisa Dhiya; Rahmadhani, Ajeng; Damayanti, Alida Rahmalia; Adha, Dinda Caesaria; Sari, Aisah Kensar Nawang Wulan; Azizah, Rauhillah Nurul; Ramadhan, Muhammad Reza; Niam, Muhammad Labib Qotrun; Wahyuni, Arifah Sri
Abdimas Galuh Vol 7, No 1 (2025): Maret 2025
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v7i1.16466

Abstract

Tanaman Obat Keluarga (TOGA) adalah tanaman hasil budidaya rumahan yang berkhasiat sebagai obat alternatif yang bisa mengobati aneka ragam penyakit. Desa Dukuh merupakan desa yang terletak di Kecamatan Ngargoyoso, Kabupaten Karanganyar, Provinsi Jawa Tengah. Desa ini memiliki berbagai potensi tapi belum dimanfaatkan secara optimal oleh masyarakat yang dibuktikan dengan banyaknya lahan pekarangan dan lahan kas desa yang belum dimanfaatkan. Kegiatan yang dilaksanakan yaitu pembangunan konservasi TOGA guna optimalisasi potensi desa, pembangunan masyarakat yang kreatif, peningkatan mutu kesehatan, dan pengembangan masyarakat cerdas. Metode pelaksanaan kegiatan program pengabdian oleh PPK Ormawa yang dilakukan dalam pembangunan konservasi TOGA yaitu berupa: 1) Survei lahan kosong 2) Persiapan lahan dan pengolahan lahan 3) Persiapan bahan 4) Pemupukan tanah hingga penanaman bibit. Kegiatan ini melibatkan masyarakat Desa Dukuh dan aparatur desa serta kelompok-kelompok pendukung seperti PKK, BUMDES, dan Karang Taruna desa. Hasil dari kegiatan pengabdian yaitu terbentuknya dua kawasan konservasi TOGA.
Sintesis Etil 4-(3,5-dimetil-4-fenoksifenil)-6-metil-2-okso-1,2,3,4-tetrahidropirimidin-5-Karboksilat dan Uji Aktivitas Sitotoksik Terhadap Sel T47D Maulina, Fariha Mufidah; Fauzi, Ahmad; Ramadhan, Muhammad Reza; Hakimah, Wafiq Kholifatul
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.772

Abstract

Cancer is one of the biggest health problems in the world, including in Indonesia. Previous studies have found that DHPM compounds have various pharmacological activities such as anticancer, antifungal, antibacterial, antituberculosis, and antioxidant. Based on this potential, it is interesting to conduct further research with the aim of synthesizing and developing new Dihydropyrimidinone (DHPM) compound derivatives that have potential as anticancer. The synthesis of DHPM derivatives was carried out to obtain ethyl 4-(4-hydroxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (M1). Then the compound was developed by Mitsunobu reaction using a sonicator to obtain a new compound ethyl 4-(3,5-dimethyl-4-phenoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (C2) which will be tested for cytotoxic activity against T47D cancer cells. Characterization of the compound was done using FT-IR, LC-MS, and melting point. Cytotoxic test against T47D cells as anticancer agent using MTT method [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide] assay. The test results of compound C2 had cytotoxic activity with IC50 of 202.22 µg/mL. The results showed that compound C2 has cytotoxic activity but it is mild because the IC50 produced is high. These findings suggest that compound C2 has anticancer potential, but further structure optimization is needed to increase its effectiveness.
SYNTHESIS OF DIHYDROPYRIMIDINONE DERIVATIVES AND CYTOTOXIC ACTIVITY TEST AGAINST T47D CANCER CELLS Hakimah, Wafiq Kholifatul; Fauzi, Ahmad; Ramadhan, Muhammad Reza; Maulina, Fariha Mufidah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1693

Abstract

Dihydropyrimidinone (DHPM) derivatives are heterocyclic compounds known for a variety of biological activities including anticancer properties. The Mitsunobu reaction was used in this study to synthesize a new DHPM derivative, ethyl 4-(4-isopropoxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (compound B2), and assess its cytotoxic activity against T47D breast cancer cells. Compound B2 was synthesized from ethyl 4-(4-hydroxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (compound M1) using multicomponent reactions (MCR) and the Mitsunobu reaction with isopropyl alcohol as the pronucleophile. Compound B2 was characterized using melting point test, FTIR and LC-MS spectroscopy, which confirmed its structure, functional groups, and molecular weight of 334.13 g/mol. MTT assay was used to evaluate cytotoxic activity. Compound B2 had an IC50 value of 205.71 µg/mL, indicating weak cytotoxicity, whereas doxorubicin had an IC50 value of 3.33 µg/mL. Despite the low cytotoxicity of compound B2, this synthesis sheds light on the development of DHPM derivatives with potential anticancer properties. The results showed that the Mitsunobu reaction is useful for modifying DHPM derivatives and highlights the need for further optimization to improve cytotoxic potency. Keywords: Dihydropyrimidinone, Mitsunobu, Cytotoxicity, T47D
Mobile-Assisted Vocabulary Learning through Duolingo: Insights from Indonesian University Students across Disciplines Puspitasari, Rina; Ramadhan, Muhammad Reza; Fadli, Ahmad; Nurhaliza, Siti
Jurnal Tahuri Vol 22 No 2 (2025): August 2025
Publisher : Jurusan Pendidikan Bahasa dan Seni FKIP Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/tahurivol22issue2page137-156

Abstract

This study investigates how students from different academic disciplines experience vocabulary learning through Duolingo, a mobile-assisted language learning (MALL) application. Unlike previous research that predominantly focuses on quantitative outcomes, this study foregrounds individual learning experiences and disciplinary variations among Indonesian university students, a context rarely explored in international scholarship. Using a qualitative multiple case study design, data were collected from ten students at Universitas Muhammadiyah Jakarta across five disciplines: Automotive and Heavy Equipment Engineering, Social Welfare, Communication, Primary School Teacher Education, and two postgraduate programs (Hospital Administration and Educational Technology). Data sources included four-week usage observations, activity logs, in-depth interviews, and reflective journals, analyzed thematically and comparatively across cases. Findings indicate that disciplinary background shapes engagement patterns and learning strategies. Engineering students display instrumental and goal-oriented behaviors, social science students engage interactively with gamified features, teacher education students integrate pedagogical perspectives, and postgraduate learners employ metacognitive strategies. Shared challenges include sustaining motivation, contextual limitations of vocabulary, and technical constraints. Overall, Duolingo enhances learner autonomy and provides flexible, personalized support that complements formal instruction. This study contributes to applied linguistics and educational technology by highlighting the role of disciplinary contexts in shaping MALL experiences and offering insights for curriculum design and language policy.
Co-Authors AA Sudharmawan, AA Adha, Dinda Caesaria Adha, Dinda Caesaria Adha Ahmad Fadli Al Fawwaz, Zulfa Kamila Amani, Khalisa Dhiya Arifah Sri Wahyuni Azis Saifudin Azizah, Rauhillah Nurul Candrika, Nasha Lulut Chandrika, Nasha Lulut Damayanti, Alida Rahmalia Fauzi Ahmad Muda Fawwaz, Zulfa Kamila Al Hakimah, Wafiq Kholifatul Kholifatul Hakimah, Wafiq Maulina, Fariha Mufidah Mufidah Maulina, Fariha Muhammad Haqqi Hidayatullah Nasywa, Nabila Luthfiana Niam, Muhammad Labib Qotrun Persada, Tashila Zahra Rahmadhani, Ajeng Rahmallia, Ega Rina Puspitasari Sari, Aisah Kensar Nawang Wulan Siti Nurhaliza Sukamto, Dandi Febrian Utama, Haya Nabilah