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All Journal Medula Manuju : Malahayati Nursing Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Keperawatan Profesional (KEPO)
Jausal, Anisa Nuraisa
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Medula

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Literature Review: Antioxidant Activity of Water Apple Leaves (Syzygium aqueum) Justisia, Adilla; Susianti; Jausal, Anisa Nuraisa; Busman, Hendri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1321

Abstract

Antioxidant is a complex inhibit, prevent or dampen the reactions of free radicals and oxidants, as well as to prevent tissue damage. Antioxidant works by donating one of its electron to oxidant compounds thereby inhibiting the activity of these oxidant compounds. An imbalance between antioxidants and free radicals, where free radicals are more prevalent, can damage molecular organisms and cause oxidative stress that triggers damage to body cells. Oxidative damage to DNA triggers mutations that initiates cancer, cardiovascular disease, neurodegenerative disorder, autoimmune diseases, aging processes and several hereditary diseases. Currently, the use of natural antioxidants as traditional treatments is widely consumed by the community. Natural antioxidants are found in several plant sources, it is known to be more affordable and have lower side effects, making it as popular treatment choice in the community. One of the plants with a high antioxidant content is the water apple leaf (Syzygium aqueum) which rich in flavonoids, phenolics, and tannins. DPPH (2,2-diphenyl-1-picrylhydrazyl) is a common method to measure antioxidant activity, it works with the principle of hydrogen capture from antioxidants by free radicals. The parameter IC50 is used to represents the sample concentration required to capture 50% of DPPH radicals. Several studies using the DPPH method have shown that water apple leaves have strong antioxidant activity, indicated by its low IC50 value. The lower the IC50 value, the stronger the antioxidant activity.
Tinjauan Pustaka: Pengaruh Obesitas, Resistensi Insulin dan Sindrom Metabolik dengan Fungsi Tiroid Fala, Arzety Rifda; Windarti, Indri; Jausal, Anisa Nuraisa; Sukohar, Asep
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1459

Abstract

The thyroid gland, located in the neck, is crucial for regulate metabolism, growth, and development by producing hormones like thyroxine (T4) and triiodothyronine (T3). These hormones influence various body functions, including heart rate, temperature control, energy production, and fat metabolism. When the thyroid gland doesn't function properly, it can cause conditions like hypothyroidism or hyperthyroidism. Factors such as obesity, insulin resistance, and metabolic syndrome can disrupt thyroid function. Obesity, characterized by excessive fat accumulation, is a global issue. This study examines how obesity, insulin resistance, and metabolic syndrome affect thyroid function. A review of fourteen relevant articles found that Thyroid Stimulating Hormone (TSH) levels are positively correlated with Body Mass Index (BMI), insulin resistance, and metabolic syndrome. The underlying mechanism is increased levels of leptin and inflammatory cytokines, which affect TSH production and thyroid function through disruption of T3 feedback. The findings indicate that obesity, insulin resistance, and metabolic syndrome lead to increased TSH as a compensatory response. This study highlights the importance of understanding the relationship between these conditions for better prevention and health management.
Co-Authors Asep Sukohar Balqis, Gasela Zalianti Ety Apriliana Fala, Arzety Rifda Fayola, Diva Haq, Rais Amaral Hendri Busman Indri Windarti Iswandi Darwis Justisia, Adilla Prayogi, Norbertus Marcell Reni Zuraida Risyhade, Vania Putri Saputra, Wahyu Agung Dwi Sianturi, Maureen Angelica br. Susianti Susianti, Susianti