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All Journal Berita Kedokteran Masyarakat Jurnal Epidemiologi Kesehatan Indonesia
Sihombing, Intan Ully Athalia
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Determinants of exacerbations in patients with chronic obstructive pulmonary disease: retrospective cohort study Sihombing, Intan Ully Athalia; Pulungan, Rafiah Maharani; Karima, Ulya Qoulan; Pristya, Terry Y.R; Soetrisno, Arief Budi; Montain, Maya Marinda
BKM Public Health and Community Medicine Vol 38 No 02 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v38i02.3788

Abstract

Purpose: Exacerbations in patients with COPD are a significant cause of morbidity and mortality because of the increased progression of COPD, which is getting worse due to frequent recurrences. This study aimed to determine the factors associated with the incidence of exacerbations in patients with chronic obstructive pulmonary disease (COPD) at the Bandung Community Lung Health Center (BCLHC). Methods: This study is a secondary data analysis of patient medical records for 2015-2020 with a retrospective cohort study design. The sample in this study amounted to 122 COPD patients who were taken using a purposive sampling technique. The variables studied were age, sex, employment status, marital status, and smoking history. The bivariate data analysis used the chi-square test, and the multivariate data analysis used the multiple Cox regression test with α = 0.05. Results: The results of the multivariate analysis showed an increased risk of exacerbations in the group with a history of smoking (RR = 7.6, 95% CI = 2.9-19.6) compared to the group with no history of tobacco and non-married status (RR = 1.9, 95% CI = 1.1-3.4) compared with the currently married group. Conclusion: It is hoped that COPD sufferers can stop smoking to reduce the risk of exacerbations and the need for support from families for COPD sufferers who are not married.
Determinan Ketidakpatuhan Kunjungan Pengambilan Obat Antiretroviral Pasien HIV/AIDS di Kabupaten Bekasi Tahun 2023-2024 Sihombing, Intan Ully Athalia; Sudaryo, Mondastri Korib; Helda, Helda; Umniyati, Helwiah; Hasyim, Irva Zulviya
Jurnal Epidemiologi Kesehatan Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Abstract

Non-adherence to scheduled antiretroviral (ARV) medication pickup can reduce treatment effectiveness, increase the risk of drug resistance, and contribute to poor HIV infection control. This study aimed to identify factors associated with missed ARV pickup appointments among people living with HIV/AIDS in Bekasi District. An analytical cross-sectional study was conducted using secondary data from HIV/AIDS patients undergoing ARV therapy in 2023–2024. Data were analyzed descriptively (univariate), using Chi-square tests (bivariate), and log-binomial regression (multivariate). Among 811 patients, 341 (42%) were recorded as non-adherent to their medication pickup schedule. The results showed that having an unsuppressed viral load (>50 copies/ml) significantly increased the risk of non-adherence (PR: 2.23; 95% CI: 1.74–2.86; p<0.001). Additionally, patients who had been on treatment for more than five years showed a higher tendency for non-adherence, although this was not statistically significant (PR: 1.17; 95% CI: 0.91–1.49; p=0.214). These findings highlight the importance of regular viral load monitoring and sustained support for long-term ARV patients to improve adherence. Keywords : HIV/AIDS, Adherence of Appointment, Viral Load, Antiretroviral Therapy, Treatment Duration
Co-Authors Hasyim, Irva Zulviya Helda Helda Helwiah Umniyati Montain, Maya Marinda Pristya, Terry Y.R Pulungan, Rafiah Maharani Soetrisno, Arief Budi Sudaryo, Mondastri Korib Ulya Qoulan Karima