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All Journal AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Anakes: Jurnal Ilmiah Analis Kesehatan Jurnal Abdimas Kartika Wijayakusuma Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Kania, Prina Puspa
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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Optimasi Metode Pemeriksaan HbA1c Secara Elektrokimia Berbasis Screen Printed Carbon Electrode Furqon, Ayi; Kania, Prina Puspa
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 10 No. 2 (2024): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v10i2.2314

Abstract

The quantification of HbA1c as an analyte used to monitor the success of diabetes treatment is generally examined in a laboratory with sophisticated technological equipment and professional staff. Point of care testing (POCT) is generally designed for practical examination at the patient's side. POCT HbA1c uses a screen-printed electrode (SPCE) reagent strip labeled with aptamer molecular imprinted polymer (MIP), boronate, or anti-HbA1c antibody and then quantified electrochemically. The linearity of the measurement works at a normal detection concentration of 5.5-8.5% but has not been tested at high critical concentrations. The purpose of this study was to optimize the electrochemical quantification method of HbA1c. The research procedure, SPCE was first activated with 0.1 M NaOH by cyclic voltammetry. Aptamer labeling (Fe3O4@MIPHbA1c) was carried out using the chronoamperometric technique and quantification was determined by the differential pulse voltammetry (DPV) technique. HbA1c stock of 6% and 10% in PBS pH 7.4 was used as normal and pathological concentration solution in accuracy and precision study (target quality CV <3%). The result, the average normal concentration of HbA1c was 5.9% ± 0.1%, CV=1.69% and pathological concentration was 10.4% ± 0.21%, CV=1.92%. The linearity test result of measurement ranged from 2%-15% R2=0.987. In conclusion, MIPHbA1c-activated SPCE showed optimal condition in HbA1c measurement in the normal and pathological range. Keywords: SPCE, HbA1c POCT, HbA1c Magnetit, HbA1c Aptamer
Upaya Pencegahan Penyebaran Covid-19 di Lingkungan Stikes Jenderal Achmad Yani Cimahi dengan Pemeriksaan Antibodi SARS-COV-2 Naully, Patricia Gita; Nursidika, Perdina; Kania, Prina Puspa; Rachmawati, Firdha
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 6 No 3 (2022): Agustus
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v6i3.6781

Abstract

Peningkatan angka kejadian Covid-19 terjadi disebabkan akibat beban populasi yang cukup tinggi di wilayah Jawa Barat. Cluster-cluster baru terdiri dari kasus di pemukiman penduduk, di mana rata-rata saat dilakukan penelusuran bisa menginfeksi anggota keluarga lainnya. Peningkatan cluster di pemukiman penduduk cukup dikhawatirkan karena beberapa penduduk sudah kurang menerapkan protokol kesehatan untuk Covid-19. Penduduk di daerah lingkungan Stikes Jenderal Achmad Yani pun termasuk kurang menerapkan protokol kesehatan, seperti sering terlihat kerumuman warga dan lalai menggunakan masker, sehingga dikhawatirkan menjadi pembawa penyakit untuk keluarga dan menimbulkan cluster baru. Lingkungan Stikes Jenderal Achmad Yani dekat dengan Rumah Sakit Pusat Rujukan Covid-19 di Jawa Barat. Program Studi Teknologi Laboratorium Medis (TLM) D-4 sebagai salah satu program studi yang terlibat dalam diagnosis penyakit, berinisiatif untuk melakukan pemeriksaan skrining Covid-19. Kegiatan ini dilakukan dengan memeriksa antibodi SARS-COV-2 dengan metode imunokromatografi terhadap 50 warga di sekitar kampus. Semua kegiatan pemeriksaan dilakukan sesuai dengan protokol yang diberlakukan oleh Kementrian Kesehatan Republik Indonesia dan World Health Organization. Hasil pemeriksaan menunjukkan 98% sampel non reaktif dan 2% reaktif. Sampel dengan hasil reaktif ditindaklanjuti dengan pemeriksaan lanjut menggunakan teknik Polymerase Chain Reaction. Selain pemeriksaan, sampel diberikan edukasi untuk tetap mengikuti protokol kesehatan dan menjaga lingkungan dari penularan Covid-19.
Optimasi Metode Pemeriksaan HbA1c Secara Elektrokimia Berbasis Screen Printed Carbon Electrode Furqon, Ayi; Kania, Prina Puspa
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 10 No. 2 (2024): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v10i2.2314

Abstract

The quantification of HbA1c as an analyte used to monitor the success of diabetes treatment is generally examined in a laboratory with sophisticated technological equipment and professional staff. Point of care testing (POCT) is generally designed for practical examination at the patient's side. POCT HbA1c uses a screen-printed electrode (SPCE) reagent strip labeled with aptamer molecular imprinted polymer (MIP), boronate, or anti-HbA1c antibody and then quantified electrochemically. The linearity of the measurement works at a normal detection concentration of 5.5-8.5% but has not been tested at high critical concentrations. The purpose of this study was to optimize the electrochemical quantification method of HbA1c. The research procedure, SPCE was first activated with 0.1 M NaOH by cyclic voltammetry. Aptamer labeling (Fe3O4@MIPHbA1c) was carried out using the chronoamperometric technique and quantification was determined by the differential pulse voltammetry (DPV) technique. HbA1c stock of 6% and 10% in PBS pH 7.4 was used as normal and pathological concentration solution in accuracy and precision study (target quality CV <3%). The result, the average normal concentration of HbA1c was 5.9% ± 0.1%, CV=1.69% and pathological concentration was 10.4% ± 0.21%, CV=1.92%. The linearity test result of measurement ranged from 2%-15% R2=0.987. In conclusion, MIPHbA1c-activated SPCE showed optimal condition in HbA1c measurement in the normal and pathological range. Keywords: SPCE, HbA1c POCT, HbA1c Magnetit, HbA1c Aptamer
ANTIFUNGAL ACTIVITY OF N-HEXANE EXTRACT FROM Chaetoceros calcitrans AGAINST Candida sp. Rachmawati, Firdha; Naully, Patricia Gita; Kania, Prina Puspa; Pasha, Delia Ayu
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6202

Abstract

Skin infections caused by Candida albicans and Candida krusei pose a serious health issue. One major concern regarding these infections is the resistance to antifungal drugs, highlighting the need for natural antifungals. Chaetoceros calcitrans, a microalgae, is known to contain natural antimicrobial compounds. This study aims to evaluate the antifungal potential of C. calcitrans n-hexane extract against both pathogens. The antifungal activity was tested using the diffusion method. The results indicated that the extract at a concentration of 100 mg mL⁻¹ inhibited the growth of C. albicans and C. krusei, showing the highest inhibition zones of 10.3 ± 0.9 mm and 9 ± 1.4 mm, respectively. GC-MS analysis revealed that the C. calcitrans extract contains antifungal compounds, including 2-Butyl-1-hexyloctahydro-1H-indene, at a concentration of 30.72%. Therefore, it can be concluded that C. calcitrans extract possesses antifungal activity and has potential as a drug candidate for fungal skin infections.
Pencegahan HIV/AIDS serta Penyakit Degeneratif melalui Edukasi dan Pemeriksaan Laboratorium pada Remaja di MAN 1 Cimahi Kania, Prina Puspa; Furqon, Ayi; Gunawan, Taufik; Khairinisa, Gina; Nursidika, Perdina; Naully, Patricia Gita; Friliansari, Lilis Puspa; Ningrum, Nining Ratna; Rachmawati, Firdha
Jurnal Abdimas Kartika Wijayakusuma Vol 6 No 3 (2025): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v6i3.726

Abstract

Remaja merupakan kelompok individu yang sedang mengalami berbagai perubahan penting, baik secara fisik maupun psikologis. Perubahan psikologis seringkali menimbulkan rasa ingin tahu yang tinggi, termasuk terhadap perilaku seks bebas yang berpotensi meningkatkan risiko penularan HIV/AIDS. Selain itu, pola makan yang kurang sehat akibat kebiasaan mengonsumsi makanan siap saji juga berdampak pada meningkatnya risiko penyakit degeneratif di kalangan remaja. Berdasarkan permasalahan tersebut, dilaksanakan kegiatan Pengabdian kepada Masyarakat (PKM) bertajuk “Pencegahan HIV/AIDS serta Penyakit Degeneratif melalui Edukasi dan Pemeriksaan Laboratorium pada Remaja di MAN 1 Cimahi.” Kegiatan ini melibatkan siswa-siswi MAN 1 Cimahi dan dilaksanakan melalui tahapan sosialisasi, pelaksanaan, serta evaluasi. Evaluasi dilakukan dengan memberikan pretest dan post-test untuk menilai peningkatan pengetahuan peserta terkait materi edukasi, serta pemeriksaan kesehatan melalui uji laboratorium. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada tingkat pengetahuan remaja setelah diberikan edukasi. Berdasarkan hasil pemeriksaan terhadap 50 siswa-siswi, seluruh peserta dinyatakan bebas HIV/AIDS dengan rata-rata kadar glukosa darah sewaktu sebesar 110,2 mg/dL. Dengan demikian, hasil skrining menunjukkan bahwa kondisi kesehatan siswa-siswi MAN 1 Cimahi berada dalam kategori normal.
ANTIFUNGAL ACTIVITY OF N-HEXANE EXTRACT FROM Chaetoceros calcitrans AGAINST Candida sp. Rachmawati, Firdha; Naully, Patricia Gita; Kania, Prina Puspa; Pasha, Delia Ayu
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.6202

Abstract

Skin infections caused by Candida albicans and Candida krusei pose a serious health issue. One major concern regarding these infections is the resistance to antifungal drugs, highlighting the need for natural antifungals. Chaetoceros calcitrans, a microalgae, is known to contain natural antimicrobial compounds. This study aims to evaluate the antifungal potential of C. calcitrans n-hexane extract against both pathogens. The antifungal activity was tested using the diffusion method. The results indicated that the extract at a concentration of 100 mg mL⁻¹ inhibited the growth of C. albicans and C. krusei, showing the highest inhibition zones of 10.3 ± 0.9 mm and 9 ± 1.4 mm, respectively. GC-MS analysis revealed that the C. calcitrans extract contains antifungal compounds, including 2-Butyl-1-hexyloctahydro-1H-indene, at a concentration of 30.72%. Therefore, it can be concluded that C. calcitrans extract possesses antifungal activity and has potential as a drug candidate for fungal skin infections.
Co-Authors Ayi Furqon, Ayi Friliansari, Lilis Puspa Gina Khairinisa Gunawan, Taufik Naully, Patricia Gita Ningrum, Nining Ratna Pasha, Delia Ayu Perdina Nursidika Rachmawati, Firdha