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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Media Penelitian dan Pengembangan Kesehatan Malahayati International Journal of Nursing and Health Science
Saputra, Nicko Pisceski Kusika
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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ANALISIS FAKTOR RISIKO DISMENORE PRIMER DAN DISMENORE SEKUNDER PADA MAHASISWI Putra, Amrullah Syah; Saputra, Nicko Pisceski Kusika; Noviardi, Noviardi; Ismawati, Ismawati
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 1 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i1.1974

Abstract

While the incidence of dysmenorrhea is relatively high worldwide, the prevalence of dysmenorrhea reported in the literature varies substantially. This study aimed to analyze the risk factors for primary dysmenorrhea and secondary dysmenorrhea. This research is a cross analytical design. The sample in this study was all medical faculty students at Riau University in 2019-2022, namely 410 people. From the research results, it was found that there was a relationship between menstrual blood volume, history of food allergies and stress with the incidence of primary dysmenorrhea. Meanwhile, the incidence of secondary dysmenorrhea was related to age, menstrual cycle, history of the sample's gestational age at birth, history of low birth weight (LBW), history of emotional violence, stress and birth history of samples from preeclamptic mothers at the time of delivery. This research concluded that there were several significant findings regarding factors related to the occurrence of dysmenorrhea in Riau University medical students in 2019 - 2022. The research showed the importance of paying attention to factors such as the length of the menstrual cycle, history of food allergies, history of emotional violence, stress, and history of maternal preeclampsia in efforts to prevent and manage dysmenorrhea in the population. It is recommended that future research further explore the association between the identified risk factors and the incidence of dysmenorrhea, potentially revealing additional insights to guide clinical practice and public health initiatives.
Vitamin D enhances migration but decreases gene expression of vascular endothelial growth factor and tumor necrosis factor-α in Wharton’s jelly mesenchymal stem cells Yuhendri, Vitriyanna Mutiara; Pratiwi, Nurfi; Paulina, Ariza Julia; Ismawati, Ismawati; Saputra, Nicko Pisceski Kusika; Arfianti, Arfianti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in biomarkers, therapeutics, and probiotics: Recent updates in medical l
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.6698

Abstract

Mesenchymal stem cells (MSCs) have gained significant interest for their potential application in repairing damaged tissues through immunomodulatory functions. Vitamin D has been shown to regulate both the innate and adaptive immune systems. Active forms of Vitamin D, such as 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are known to influence the action of mesenchymal stem cells (MSCs) in several mechanisms, such as stimulating their proliferation and osteogenic differentiation, as well as tissue regeneration. This study aimed to investigate the effects of vitamin D supplementation on the biological properties and expression of cytokines and growth factor genes in MSCs isolated from the human umbilical cord (UC). MSCs were isolated from Wharton’s jelly (WJ-MSC) of UC, cultured, and supplemented with various concentrations of vitamin D3. The Cell Counting Kit-8 (CCK-8) assay was used to measure cell viability, and a scratch wound healing assay was conducted to evaluate the migration capacity of MSCs. The mRNA expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were quantified using reverse transcription-polymerase chain reaction (RT-PCR). This study showed that supplementation with 50 nM of vitamin D3 for 48 h significantly increased the viability and migratory capacity of MSCs. Furthermore, vitamin D supplementation significantly decreased the mRNA levels of TNF-α and VEGF but did not affect IL-6 gene expression compared to the control group. These findings suggest that vitamin D supplementation can enhance the biological characteristics and modulate the expression of key immunomodulatory factors in MSCs, potentially improving the effectiveness of MSC-based therapies.
Subcutaneous endometriosis associated with adenomyosis: A complex multidisciplinary surgical case Wulandari, Riza; Saputra, Nicko Pisceski Kusika; Lubis, Munawar Adhar
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 12 (2026): Volume 8 Number 12
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i12.1944

Abstract

Background: Abdominal wall endometriosis is an uncommon extrapelvic form of endometriosis, most often developing at a previous gynecologic surgical scar. Patients typically report cyclical pain with or without a palpable mass, and diagnosis is frequently delayed because the presentation can mimic hernia, granuloma, lipoma, or desmoid tumor. Purpose: To describe the clinical presentation, imaging findings, perioperative optimization, surgical management, and histopathological confirmation of abdominal wall endometriosis coexisting with adenomyosis in a patient with significant medical comorbidities. Method: A case report was performed in a 45-year-old multiparous woman with a five-year history of progressive lower abdominal pain that worsened during menstruation and localized to a prior surgical scar. Pelvic ultrasonography identified adenomyosis and a 6.9 × 3.9 cm hypoechoic lesion in the anterior abdominal wall, raising suspicion of subcutaneous endometriosis. Results: Surgical exploration showed a lesion extending through the subcutaneous tissue and fascia, with focal involvement of the rectus muscle. Complete excision was achieved after preoperative optimization, and the postoperative course was uneventful. Histopathological examination of two specimens (9 × 6 × 4 cm and 5 × 2 × 1 cm) demonstrated fibrocollagenous tissue, adipose tissue, and skeletal muscle infiltrated by endometrial glands, confirming abdominal wall endometriosis. Conclusion: Abdominal wall endometriosis should be considered in women presenting with cyclical pain at a surgical scar. Imaging supports assessment of lesion extent and surgical planning, while histopathology remains essential to confirm the diagnosis and to exclude rare malignant transformation.
Co-Authors Arfianti Arfianti Ariza Julia Paulina Ismawati ismawati Lubis, Munawar Adhar Noviardi Noviardi, Noviardi Nurfi Pratiwi, Nurfi Putra, Amrullah Syah Wulandari, Riza Yuhendri, Vitriyanna Mutiara