Article Per Year (5 Year)
p-Index From 2021 - 2026
0.961
P-Index
This Author published in this journals
All Journal Health & Medical Sciences Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Pharmacology and Natural Products
Mohamad Adam Mustapa
Universitas Negeri Gorontalo
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Uji Efektivitas Antihiperurisemia Ekstrak Metanol Daun Durian (Durio Zibethinus L.) Pada Mencit (Mus Musculus) Mohamad Adam Mustapa; Endah Nurrohwinta Djuwarno; Widysusanti Abdul Kadir; Faradhilah Pratiwi Yasilu
Journal of Pharmacology and Natural Products Vol. 3 No. 1 (2026): Volume 3, Nomor 1, Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v3i1.153

Abstract

Kondisi hiperurisemia adalah kadar asam urat darah terjadi peningkatan yaitu 3,4-7,0mg/dL pada pria-laki dan wanita 2,4- 6,0mg/dL. Penggunaan obat hiperurisemia dikalangan masyarakat sangat beragam mulai dari obat sintetik dan obat tradisional. Banyak masyarakat yang masih menggunakan obat-obatan yang berasal dari bahan alam karena terbukti ampuh menyembuhkan penyakit dan penggunaannya lebih efektif, efisien, aman dan ekonomis. Salah satu tanaman yang dapat digunakan dalam pengobatan tradisional adalah daun Durian ( Durio zibethinus L.). Penelitian ini bertujuan untuk mengetahui efektivitas antihiperusemia pada ekstrak metanol daun Durian ( Durio zibethinus L. ) . Metode penelitian ini menggunakan metode maserasi total, skrining fitokimia dan uji efektivitas antihiperurisemia. Uji efektivitas antihiperurisemia dilakukan menggunakan uji hewan mencit jantan yang dibagi menjadi 5 kelompok perlakuan yaitu kelompok 1 merupakan kelompok kontrol positif (Allopurinol 100mg), kelompok 2 merupakan kelompok kontrol negatif (Na-CMC 1%), kelompok 3 merupakan kelompok uji 1 (Dosis 125mg /kg BB), kelompok 4 merupakan kelompok uji 2 (Dosis 150mg/kg BB), dan kelompok 5 merupakan kelompok uji 3 (Dosis 175mg/kg BB). Hasil penelitian menunjukkan bahwa kelompok Uji ekstrak metanol daun Durian ( Durio zibethinus L.) dengan dosis 175 mg/kg BB menunjukkan efektivitas antihiperurisemia yang paling baik. Dibuktikan dengan penurunan kadar asam urat hingga 3,16 mg/dL. Selanjutnya diikuti oleh kelompok kontrol positif (Allopurinol 100 mg) dan kelompok uji ekstrak dengan dosis 150 mg/kg BB dan 125 mg/kg BB.
Formulation and Physical Evaluation of Lavender (Lavandula angustifolia) Essential Oil Aromatherapy Candles Tri Sucianita T. Tama; Nurain Thomas; Ariani H. Hutuba; Mohamad Adam Mustapa
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 2 (2026): Volume 3 Nomor 2 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i2.147

Abstract

Lavender flowers are widely used in aromatherapy because their principal constituents, linalyl acetate and linalool, are associated with relaxing effects. Aromatherapy preparations contain volatile aromatic substances intended to promote calmness and relaxation. This study aimed to formulate and physically evaluate aromatherapy candles containing lavender (Lavandula angustifolia) essential oil. An experimental laboratory design was employed, with lavender essential oil as the active ingredient and variations in beeswax and stearic acid concentrations. Formula I contained 50% soy wax, 50% beeswax, and 25% stearic acid, whereas Formula II contained 50% soy wax, 60% beeswax, and 30% stearic acid. The formulations were evaluated for organoleptic characteristics, burning performance, melting point, and hedonic acceptance. Both formulations met the specified physical-evaluation criteria, demonstrating that lavender essential oil can be successfully incorporated into aromatherapy candle formulations
Effect of Centrifugation on Nanoemulsion Stability with Tween, PEG, Poloxamer 188, and Transcutol-p Fauziah Rahmola; Mohamad Adam Mustapa; Mohamad Aprianto Paneo; Endah Nurrohwinta Djuwarno; Muhammad Taupik
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.271

Abstract

This study evaluated the effect of centrifugation speed on the physical stability of a nanoemulsion base formulated with grapeseed oil (long-chain triglyceride, LCT) and stabilized using Tween 80–PEG 400, Poloxamer 188, and Transcutol-P, as a preliminary platform for topical and oral pharmaceutical applications. A descriptive–experimental design was employed. Nanoemulsion bases were prepared by the aqueous titration method followed by 60-minute sonication. Four formulations (F1–F4) contained 5% grapeseed oil and 2% Poloxamer 188, while Tween 80/PEG 400 levels and Transcutol-P (0.5–2%) were varied. Accelerated physical stability was assessed by centrifugation at 2000, 4000, 6000, and 8000 rpm for 30 minutes, followed by organoleptic observation, emulsion type determination, pH measurement, and viscosity testing. All formulations remained visually stable at 2000 rpm. At 4000 rpm, F1–F2 showed increased turbidity with a thin top layer (incipient creaming), whereas F3–F4 remained stable without phase separation. At 6000 rpm, F1–F2 became more turbid with the onset of a surface oil layer, while F3–F4 maintained stability. At 8000 rpm, F1–F2 exhibited complete phase separation; F3 showed a slight oil layer; and F4 was the most stable, showing only minimal turbidity without total phase breaking. All formulations were classified as oil-in-water (O/W). The pH ranged from 6.0 to 7.0 (mean 6.45 ± 0.42) and viscosity from 176 to 220 cP (mean 196.25 ± 18.89). In conclusion, increasing centrifugation speed effectively differentiated formulation robustness, with F4 demonstrating the highest resistance to mechanical stress up to 8000 rpm.
The Effect of Centrifugation Test on the Physical Stability of Nanoemulsion Containing a Combination of Poloxamer 407, Tween 80, PEG 400, and DMSO Rani Orelia A. Unga; Teti Sutriyati Tuloli; Mohamad Aprianto Paneo; La Ode Aman; Mohamad Adam Mustapa
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.272

Abstract

The development of nanoemulsion-based drug delivery systems has gained significant attention due to their ability to enhance drug solubility, stability, and therapeutic effectiveness. Optimizing the combination of surfactants, co-surfactants, and penetration enhancers is essential to produce a kinetically stable nanoemulsion system. This study aimed to formulate and evaluate the physical stability of nanoemulsions prepared using Tween 80, PEG 400, Poloxamer 407, and dimethyl sulfoxide (DMSO), and to determine the optimal formulation based on physicochemical characteristics and accelerated stability testing. Four nanoemulsion formulations (F1–F4) were prepared with varying concentrations of surfactant and co-surfactant. The formulations were evaluated for organoleptic properties, emulsion type, pH, viscosity, and physical stability using a centrifugation test at speeds up to 8000 rpm to detect phase separation, flocculation, or coalescence. The results showed that all formulations were classified as oil-in-water (o/w) nanoemulsions. No phase separation was observed after centrifugation, indicating good physical stability. However, F1 and F2 appeared turbid, whereas F3 and F4 demonstrated better clarity and overall stability. The pH values ranged from 6.6 to 7.4, which are acceptable for topical application, and viscosity values ranged from 405 to 427 cPs, indicating suitable rheological properties for topical use. In conclusion, the combination of Tween 80, PEG 400, Poloxamer 407, and DMSO successfully produced a kinetically stable nanoemulsion system. Among the tested formulations, F3 and F4 exhibited the most optimal characteristics and show strong potential for further development in pharmaceutical nanoemulsion formulations.
Effect of Centrifugation on the Stability of Nanoemulsion Base Containing Tween 80, PEG 400, Poloxamer 188, and DMSO Karmila Lihawa; Mohamad Adam Mustapa; Mohamad Aprianto Paneo; Widy Susanti Abdulkadir; Muhammad Taupik
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.277

Abstract

Nanoemulsions are biphasic dispersion systems (oil and water) with nanometer-scale droplet sizes that exhibit better physical stability than conventional emulsions and are widely utilized in pharmaceutical and cosmetic applications. The kinetic stability of nanoemulsions is strongly influenced by the composition of surfactants, co-surfactants, and other supporting components. This study aimed to evaluate the effect of centrifugation on the physical stability of an olive oil–based nanoemulsion with varying concentrations of Tween 80 and PEG 400, supported by Poloxamer 188 and DMSO. This laboratory-based experimental study employed the aqueous titration method for nanoemulsion preparation, followed by ultrasonication for 60 minutes. Accelerated stability testing was conducted through centrifugation at speeds of 2,000, 4,000, 6,000, and 8,000 rpm for 30 minutes. Physical evaluations included organoleptic testing, pH measurement, viscosity determination, and emulsion type identification using the methylene blue dye method. The results showed that all formulations remained stable at 2,000–4,000 rpm. At 6,000 rpm, formulations F1 and F2 began to exhibit partial creaming, and at 8,000 rpm significant phase separation was observed in F1 and F2, whereas F3 and F4 remained clear and homogeneous. The pH values of all formulations ranged from 6.8 to 7.3 (7.03 ± 0.22), indicating good chemical stability. Viscosity values ranged from 103 to 132 cPs (111.5 ± 13.77), which fall within the acceptable range for nanoemulsion systems. The emulsion type test showed a homogeneous blue color distribution, confirming that all formulations were oil-in-water (O/W) systems. In conclusion, the ratio of Tween 80 to PEG 400 plays a crucial role in enhancing the kinetic stability of olive oil–based nanoemulsions. Formulations F3 and F4 demonstrated the most optimal physical stability and have strong potential for further development in pharmaceutical and cosmetic applications.
Kelayakan Fasilitas Satuan Pelayanan Pemenuhan Gizi (SPPG) di Kota Gorontalo Mohamad Adam Mustapa; Mentari Abdul Latif; Nurhayati Kadir; Indah Siti Hardiyanti; Anwar Ibrahim; Teti Sutriyati Tuloli; Rathiana K. Abdussamad
Health & Medical Sciences Vol. 3 No. 4 (2026): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v3i4.637

Abstract

Penelitian ini bertujuan untuk menilai kelayakan fasilitas Satuan Pelayanan Pemenuhan Gizi (SPPG) di Kota Gorontalo dalam mendukung implementasi Program Makan Bergizi Gratis (MBG) berdasarkan standar Badan Gizi Nasional (BGN). Penelitian menggunakan metode deskriptif analitik melalui kajian literatur dan analisis dokumen kebijakan dengan memanfaatkan data sekunder dari laporan resmi BGN, pemerintah daerah, media nasional, serta hasil inspeksi lapangan periode September 2025–Mei 2026. Data dianalisis menggunakan teknik triangulasi sumber berdasarkan aspek infrastruktur, sanitasi, keamanan pangan, distribusi, dan sumber daya manusia. Hasil penelitian menunjukkan bahwa dari 89 SPPG yang beroperasi di Provinsi Gorontalo, sebanyak 11 unit di Kota Gorontalo masih berstatus suspensi akibat belum memenuhi standar Instalasi Pengolahan Air Limbah (IPAL) serta ditemukannya pelanggaran keamanan pangan, seperti makanan berjamur, pengelolaan bahan baku yang tidak memenuhi standar, dan keterbatasan armada distribusi. Sebaliknya, SPPG Hutuo telah memenuhi sebagian besar standar BGN sehingga dapat dijadikan model pengelolaan fasilitas MBG. Program MBG telah menjangkau sekitar 131.679 penerima manfaat dan menyerap sekitar 3.780 tenaga kerja. Disimpulkan bahwa kelayakan fasilitas SPPG di Kota Gorontalo masih memerlukan peningkatan terutama pada aspek sanitasi, keamanan pangan, kapasitas distribusi, dan pengawasan operasional agar pelaksanaan Program MBG dapat berlangsung secara efektif, aman, dan berkelanjutan.
Co-Authors Anwar Ibrahim Ariani H. Hutuba Endah Nurrohwinta Djuwarno Faradhilah Pratiwi Yasilu Fauziah Rahmola Indah Siti Hardiyanti Karmila Lihawa La Ode Aman Mentari Abdul Latif Mohamad Aprianto Paneo Muhammad Taupik Nur Ain Thomas Nurhayati Kadir Rani Orelia A. Unga Rathiana K. Abdussamad Teti Sutriyati Tuloli Tri Sucianita T. Tama Widy Susanti Abdulkadir Widysusanti Abdul Kadir