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All Journal Scientific Journal of Pediatrics Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Neurology Sriwijaya Journal of Otorhinolaryngology
Andhika Kurnianta Kusuma
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Burning Mouth Syndrome: Exploring the Role of Central Sensitization and Neuropathic Pain Mechanisms in Bandung, Indonesia Muhammad Ashraf; Syaifudin Syaifudin; Andhika Kurnianta Kusuma; Duru Carissa Neuer; Eduardo Michael Perez
Sriwijaya Journal of Neurology Vol. 3 No. 1 (2025): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v2i2.170

Abstract

Introduction: Burning mouth syndrome (BMS) is a chronic pain condition characterized by a burning sensation in the oral cavity without any identifiable clinical or laboratory findings. While the etiology of BMS remains unclear, central sensitization and neuropathic pain mechanisms are increasingly recognized as potential contributors. This study aimed to investigate the role of central sensitization and neuropathic pain in BMS patients in Bandung, Indonesia. Methods: This cross-sectional study involved 40 participants diagnosed with BMS according to the International Association for the Study of Pain (IASP) criteria and 40 healthy controls. All participants underwent comprehensive assessments, including: (1) clinical oral examination, (2) quantitative sensory testing (QST) to assess thermal and mechanical sensitivity, (3) questionnaires to evaluate pain intensity, quality of life, anxiety, and depression, and (4) measurement of salivary cortisol levels as a marker of stress. Results: BMS patients exhibited significantly higher thermal and mechanical sensitivity compared to healthy controls (p<0.001). They also reported significantly higher pain intensity, poorer quality of life, and increased levels of anxiety and depression (p<0.001). Salivary cortisol levels were significantly elevated in the BMS group (p<0.05). Correlation analysis revealed significant associations between pain intensity and QST parameters, anxiety, depression, and salivary cortisol levels. Conclusion: The findings of this study suggest that central sensitization and neuropathic pain mechanisms play a significant role in the pathophysiology of BMS in Bandung, Indonesia. These findings highlight the need for a multidisciplinary approach to BMS management, incorporating strategies to address both peripheral and central factors contributing to pain.
Early Childhood Feeding Practices and the Development of Severe Early Childhood Caries (S-ECC): A Prospective Cohort Study in Medan, Indonesia Andhika Kurnianta Kusuma; Muhammad Ashraf; Yi-Fen Huang; Aprilia Sari; Firman Hadi; Sohyuk Kim
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.175

Abstract

Introduction: Severe early childhood caries (S-ECC) is a significant public health problem, particularly in developing countries like Indonesia. Early childhood feeding practices are recognized as major risk factors, but prospective data from specific regions like Medan, Indonesia, are limited. This study aimed to investigate the association between various feeding practices and the development of S-ECC in a cohort of children in Medan. Methods: A prospective cohort study was conducted involving 450 mother-child dyads recruited from Posyandu (integrated health posts) in Medan, Indonesia. Baseline data on maternal demographics, socioeconomic status, oral health knowledge, and infant feeding practices were collected via questionnaires and interviews. Children were followed up at 6-month intervals for 36 months. Dental examinations were performed by calibrated dentists using the dmft index (decayed, missing, filled teeth) to diagnose S-ECC. Cox proportional hazards regression was used to analyze the association between feeding practices and S-ECC development, adjusting for potential confounders. Results: The incidence of S-ECC at 36 months was 38.2% (n=172). Prolonged bottle feeding (beyond 12 months) (Hazard Ratio [HR] = 2.15; 95% Confidence Interval [CI]: 1.55-2.98; p<0.001), nocturnal bottle feeding with sweetened liquids (HR = 2.85; 95% CI: 2.01-4.03; p<0.001), and frequent consumption of sugary snacks/drinks (≥3 times/day) (HR = 1.92; 95% CI: 1.38-2.67; p<0.001) were significantly associated with an increased risk of S-ECC. Exclusive breastfeeding for the first 6 months showed a protective effect (HR = 0.62; 95% CI: 0.45-0.86; p=0.004), even after adjusting for socioeconomic status and maternal oral health knowledge. Conclusion: This study confirms the significant impact of early childhood feeding practices on S-ECC development in Medan, Indonesia. Prolonged and nocturnal bottle feeding, particularly with sweetened liquids, and frequent consumption of sugary snacks/drinks were key risk factors. Promoting exclusive breastfeeding for the first six months and educating mothers about appropriate feeding practices are crucial for S-ECC prevention in this population.
Development and Validation of the Indonesian Voice Handicap Index Adapted for Javanese and Sundanese Speakers (I-VHI-JS) Hasrita Soleiman; Andhika Kurnianta Kusuma; Eduardo Michael Perez
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 1 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v2i2.186

Abstract

Introduction: Voice disorders significantly impact quality of life. The Voice Handicap Index (VHI) is a widely used patient-reported outcome measure, but its applicability is limited by linguistic and cultural factors. Indonesia, with its diverse languages, requires culturally adapted versions. This study aimed to develop and validate the Indonesian Voice Handicap Index adapted for Javanese and Sundanese speakers (I-VHI-JS). Methods: The original English VHI was translated into Indonesian, Javanese, and Sundanese using a rigorous forward-backward translation process. A cross-sectional study was conducted involving three groups: (1) individuals with voice disorders (n=150; Javanese speakers = 75, Sundanese speakers = 75), (2) age- and gender-matched vocally healthy controls (n=150; Javanese speakers = 75, Sundanese speakers = 75), and (3) a test-retest reliability group (n=50; Javanese speakers = 25, Sundanese speakers = 25) from the voice disorder group. Participants completed the appropriate I-VHI-JS version. Otolaryngological examination and acoustic voice analysis (jitter, shimmer, noise-to-harmonics ratio) were performed. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient - ICC), construct validity (known-groups comparison), concurrent validity (correlation with acoustic parameters), and discriminant validity (receiver operating characteristic - ROC curve analysis) were assessed. Results: The I-VHI-JS demonstrated excellent internal consistency (Cronbach's alpha > 0.90 for all versions) and test-retest reliability (ICC > 0.85 for all versions). Significant differences in I-VHI-JS scores were found between the voice disorder and control groups (p < 0.001) for all language versions, confirming construct validity. Moderate correlations were observed between I-VHI-JS scores and some acoustic parameters (e.g., jitter, r = 0.45, p < 0.01; shimmer, r = 0.40, p < 0.01). ROC curve analysis showed excellent discriminant ability (area under the curve - AUC > 0.80 for all versions). Conclusion: The I-VHI-JS is a reliable and valid instrument for assessing voice-related handicaps in Indonesian, Javanese, and Sundanese speakers. It can be used in clinical practice and research to evaluate the impact of voice disorders and monitor treatment outcomes.
Comparative Effectiveness of KDIGO 2021 versus Previous Blood Pressure Targets on Renal Outcomes in Chronic Kidney Disease Patients in Palembang, Indonesia Jonah Abraham; Andhika Kurnianta Kusuma
Sriwijaya Journal of Internal Medicine Vol. 2 No. 1 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v1i2.78

Abstract

Introduction: The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend lower blood pressure (BP) targets for chronic kidney disease (CKD) patients compared to previous guidelines. This study aimed to evaluate the comparative effectiveness of achieving KDIGO 2021 BP targets versus previous targets on renal outcomes in CKD patients in Palembang, Indonesia. Methods: A retrospective cohort study was conducted involving CKD patients (stages 1-5, not on dialysis) attending a tertiary hospital in Palembang from January 2018 to December 2023. Patients were categorized into two groups: those achieving KDIGO 2021 BP targets (<120/80 mmHg) and those achieving previous targets (<130/80 mmHg). The primary outcome was a composite of renal events including a 50% decline in estimated glomerular filtration rate (eGFR), end-stage renal disease (ESRD), or renal death. Secondary outcomes included individual components of the composite outcome and all-cause mortality. Data were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression. Results: A total of 860 CKD patients were included (mean age 58.2 ± 12.5 years, 52% male). 345 patients achieved KDIGO 2021 BP targets, while 515 achieved previous targets. Over a median follow-up of 3.8 years, the primary composite outcome occurred in 187 patients (21.7%). The incidence rate of the primary outcome was significantly lower in the KDIGO 2021 group (15.6 per 1000 person-years) compared to the previous targets group (27.2 per 1000 person-years) (p=0.003). After adjusting for potential confounders, achieving KDIGO 2021 BP targets was independently associated with a lower risk of the primary outcome (hazard ratio [HR] 0.56, 95% confidence interval [CI] 0.38-0.83, p=0.004). Similar findings were observed for individual components of the composite outcome and all-cause mortality. Conclusion: Achieving KDIGO 2021 BP targets was associated with a significant reduction in the risk of adverse renal outcomes and all-cause mortality in CKD patients in Palembang. These findings support the implementation of the updated KDIGO guidelines in this population.
Co-Authors Aprilia Sari Duru Carissa Neuer Eduardo Michael Perez Firman Hadi Hasrita Soleiman Jonah Abraham Muhammad Ashraf Sohyuk Kim Syaifudin Yi-Fen Huang