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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Sains dan Kesehatan
Bulu, Atalia Tamo Ina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Biji Lamtoro (Leucaena leucocephala) terhadap Bakteri Propionibacterium acnes: Aktivitas Antibakteri Ekstrak Etil Asetat Kulit Biji Lamtoro (Leucaena leucocephala) terhadap Bakteri Propionibacterium acnes Bulu, Atalia Tamo Ina; Shalsabilla, Lulu; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p130-142

Abstract

Acne is an inflammation that is accompanied by blockage of the ducts of the skin’s oil glands (sebum) and hair (pilosebaceous ducts). Propionibacterium acnes is one of the bacteria that contribute to acne. Some natural ingredients such as lamtoro seed husk have flavonoids, alkaloids, saponins, and tannins which are antibacterial compounds that inhibit the growth of Propionibacterium acnes. This study aims to determine the antibacterial activity of ethyl acetate extract from lamtoro seed husk which is effective in inhibiting the growth of Propionibacterium acnes. Lamtoro seed husk (Leucaena leucocephala) was extracted by remaceration method using ethyl acetate solvent. Phytochemical identification is done qualitatively through color reaction with appropriate reagents confirmed by the TLC test. The results of the analysis showed that ethyl acetate extract of lamtoro seed husk had antibacterial activity against the growth of Propionibacterium acnes bacteria with the average diameter of the inhibition zone in the 15%, 20%, and 25% extract concentrations series of 1,454 mm, 3,313 mm, and 5,763 mm. Based on this study, it can be concluded that there is an influence of the concentration of ethyl acetate extract of lamtoro seed husk on the antibacterial activity of Propionibacterium acnes, the greater the concentration of the extract, the greater the diameter of the inhibition zone.
Pengaruh Kombinasi Ekstrak Daun Mengkudu (Morinda citrifolia L.) dan Daun Alpukat (Persea americana Mill.) terhadap Staphylococcus aureus: Effect of Combination of Noni Leaf Extract (Morinda citrifolia L.) and Avocado Leaves (Persea americana Mill.) on Staphylococcus aureus Sawal, Rizky Ardian Hartanto; Priamsari, Margaretha Retno; Bulu, Atalia Tamo Ina; Wulandari, Dwi
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2397

Abstract

Noni leaves (Morinda citrifolia L.) and avocado leaves (Persea americana Mill.) contain various phytochemical compounds for their antimicrobial properties. This study aims to evaluate the potential of a combination of extracts from these leaves in inhibiting the growth of Staphylococcus aureus bacteria. The maceration method was used to extract both leaves with 70% ethanol solvent, followed by phytochemical screening through tube tests and TLC. Antibacterial activity was evaluated using the well method on NA media. Concentration variations of noni and avocado leaf extracts were done in ratios of 0:100, 100:0, 50:50, 25:75, and 75:25, with positive controls using amoxicillin and negative controls using DMSO. The results showed that single extracts were most effective at pure concentrations, while the best combination extract was observed at a ratio of 75:25. However, significant differences were noted between the effects of single extracts and combinations, indicating that the combination extract has potential antibacterial activity. Keywords:          Morinda citrifolia L., Persea americana Mill., Wells, antibacterial, Staphylococcus aureus   Abstrak Daun mengkudu (Morinda citrifolia L.) dan daun alpukat (Persea americana Mill.) mengandung sejumlah senyawa fitokimia seperti flavonoid, saponin, tanin, alkaloid, dan lainnya yang dikenal memiliki sifat antimikroba. Penelitian ini bertujuan untuk mengevaluasi potensi kombinasi ekstrak kedua daun tersebut dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode maserasi digunakan untuk mengekstraksi kedua daun dengan pelarut etanol 70%, diikuti oleh skrining fitokimia melalui uji tabung dan uji KLT. Aktivitas antibakteri dievaluasi menggunakan metode sumuran pada media NA. Variasi konsentrasi ekstrak daun mengkudu dan alpukat dilakukan dalam rasio 0:100, 100:0, 50:50, 25:75, dan 75:25, dengan kontrol positif menggunakan amoksisilin dan kontrol negatif menggunakan DMSO. Hasilnya menunjukkan bahwa ekstrak tunggal paling efektif pada konsentrasi murni, sementara kombinasi ekstrak terbaik terlihat pada rasio 75:25. Meskipun demikian, perbedaan signifikan terlihat antara efek ekstrak tunggal dan kombinasi, menunjukkan bahwa kombinasi ekstrak tersebut tetap memiliki aktivitas antibakteri yang potensial. Kata Kunci:         Morinda citrifolia L., Persea americana Mill., Sumuran, antibakteri, Staphylococcus aureus
Efektivitas Ekstrak Etanol Herba Patik Emas (Euphorbia heterophylla L.) dalam Menurunkan Kolesterol Total Pada Tikus Jantan Obesitas terinduksi Diet Tinggi Lemak. Novembrina, Metrikana; Wahyuni, Tri; Anggrahini, Siti Nur Muthia; Bulu, Atalia Tamo Ina
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p192-196

Abstract

Obesity can cause various health problems such as cardiovascular disease and methabolic syndromme (insuline resistance, type 2 diabetes, hypertension und dyslipidemia). Various drug treatments have also been introduced into the community such as simvastatin, gemfibrozil and klorfibrat. These medicines are also considered unsafe if it is used permanently or excessively. Obesity can also bring about dyslipidemia. Hence, the bioactive agent which can burn the visceral fat is definetely needed. In Indonesia there is a great number of weeds which have been identified as a plant that has certain pharmacological effect in human’s body. One of them is wild poinsettia (Euphorbia heterophylla L.) which has also been proven to be effective as an antioxidant and blood glucose-lowering agent through some studies. This was a laboratory experimental study with a post-test only controlled group design. A number of 30 wistar strain white male rats were devided into 6 groups. Group 1 was normal control, group 2 was negative control (CMC Na 0,5 %), Group 3 was a positive control (gemfibrozil), group 4,5 and 6 were the ethanolic extract of wild poinsettia’s herbs in the doses of 250, 500 and 750 mg/kgBW respectively. Previously the total cholesterol level was measured to all testing animals. Before the trial, all testing animals except normal control were given high fat diet for two weeks. The total cholesterol and the body weight were then measured to observe the increase of the level. To the group 2,3,4,5 and 6 then were given the plecebo (CMC Na 0,5%), gemfibrozil, the extracts of 250, 500, and 750 mg/kgBW respectively for two weeks. The body weight and the total cholesterol were then measured again. The results showed that the ethanol extract of the wild poinsettia herb’s extract at a dose of 250 mg / kgBW was effective in reducing total cholesterol levels compared to the negative control. The dose of 750 mg / kgBW showed a maximum lowering effect of total cholesterol levels. Based on the results, it can be concluded that the ethanol extract of wild poinsettia has effectiveness in reducing total cholesterol levels of obese male rats induced by a high-fat diet. 
Perbandingan Kadar Total Flavonoid Ekstrak Daun Ketapang (Terminalia catappa L) berdasarkan Kekeringan Simplisia dengan Metode Spektrofotometri UV-Vis Pratiwi, Anastasia Eka; Bulu, Atalia Tamo Ina; Sawal, Rizky Ardian Hartanto; Pitarisa, Agustina Putri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p203-209

Abstract

Traditional treatment remains one of the widely used treatment methods to this day. One of the plants with potential as conventional medicine is the Ketapang leaf (Terminalia catappa L), which belongs to the Combretaceae family. Ketapang leaves contain various compounds such as flavonoids, alkaloids, tannins, and saponins, with flavonoids known for their high antioxidant properties. This study aims to compare the total flavonoid content in fresh and dried Ketapang leaf extracts. The extraction method used is maceration with 96% ethanol solvent. Evaluation includes organoleptic tests, moisture content, drying shrinkage, phytochemical screening, and thin-layer chromatography (TLC). Total flavonoid content testing is conducted using the colorimetric method with UV-Vis spectrophotometry at a wavelength of 430 nm, with quercetin as the standard. The results show that the yield of fresh Ketapang leaves was 8.74% w/w, while dried Ketapang leaves were 8.40% w/w. In the TLC tested, the Rf values of fresh and dried Ketapang leaf extracts were 0.95 and 0.94, respectively. The total flavonoid content in fresh Ketapang leaf extract was 24.19 mgQE/gram, while for dried Ketapang leaf extract it was 16.84 mgQE/gram. Statistical analysis with an independent sample t-test showed a significant difference (p<0.05) between fresh and dried Ketapang leaf extracts.
Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol: Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol Wahyuningtiastuti, Ananta; Bulu, Atalia Tamo Ina; Priamsari, Margareta Retno; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p188-195

Abstract

Food waste refers to discarded food materials at the final stage of the food supply chain. One such waste product with potential for utilization in traditional medicine is pineapple peel (Ananas comosus (L.) Merr.), which contains various secondary metabolites, including flavonoids, alkaloids, saponins, and tannins. Among these metabolites, flavonoids are well-known for their antioxidant properties. This study aimed to compare the total flavonoid content in ethanol extracts of pineapple peel subjected to two different drying methods. The drying methods used were sun drying and oven drying at 50 °C. The dried pineapple peels were extracted using 96% ethanol through the Soxhlet extraction method. Phytochemical constituents were identified through colorimetric reactions and Thin Layer Chromatography (TLC). The total flavonoid content was determined colorimetrically using AlCl₃ reagent and measured by UV-Visible spectrophotometry at a wavelength of 439 nm, with quercetin used as the standard. The results indicated that the extract yields from the sun-dried and oven-dried samples were 5.60% and 5.75% (w/w), respectively. TLC analysis revealed Rf values of 0.85, 0.80, and 0.91. The total flavonoid content in the sun-dried sample was 35.44 ± 0.55 mgQE/g, while that in the oven-dried sample was 25.40 ± 0.98 mgQE/g. Statistical analysis using the Independent Sample t-test demonstrated a significant difference in total flavonoid content between the two drying methods.
Identifikasi Bahan Kimia Obat dalam Sediaan Jamu Pegal Linu Menggunakan Metode Spektroskopi Inframerah Christina, Odilia Dea; Yudhantara, Sandi Mahesa; Solichah, Ayu Ina; Bulu, Atalia Tamo Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p150-156

Abstract

Pegel linu herbal medicine is one of the traditional remedies widely consumed by the community to relieve pain and fatigue. The high market demand, particularly through online marketplaces, has the potential to be misused by irresponsible producers by illegally adding pharmaceutical chemicals to enhance therapeutic effects. This study aimed to identify the presence of pharmaceutical adulterants, namely paracetamol, sodium diclofenac, and dexamethasone, in peg el linu herbal medicines circulating in the market using Fourier Transform Infrared (FTIR) spectroscopy. Ten herbal medicine samples were selected using purposive sampling based on criteria such as the absence of distribution permit numbers or the presence of exaggerated therapeutic claims. The samples were prepared through extraction procedures and analyzed using FTIR-ATR by comparing the sample spectra with reference standards. The results showed that one sample tested positive for paracetamol and one sample tested positive for dexamethasone, while sodium diclofenac was not detected in any of the samples. The presence of pharmaceutical adulterants was identified based on the appearance of characteristic functional groups such as O–H, N–H, and C=O at specific wavenumbers. These findings indicate that some peg el linu herbal medicines circulating in the market still contain illegal pharmaceutical adulterants, which may pose potential health risks to consumers.
Co-Authors Anggrahini, Siti Nur Muthia Ayu Ina Solichah Dwi Wulandari Margareta Retno Priamsari Novembrina, Metrikana Odilia Dea Christina Pitarisa, Agustina Putri Pratiwi, Anastasia Eka Priamsari, Margaretha Retno Sawal, Rizky Ardian Hartanto Shalsabilla, Lulu Solichah, Ayu Ina tri wahyuni Wahyuningtiastuti, Ananta Yudhantara, Sandi Mahesa