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Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Abstract

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.
Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Abstract

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.
Methicillin-Resistant Staphylococcus Aureus in orthopedic surgery: Current evidence from diagnosis until rehabilitative management Handoko, Yosia; Johan, Muhammad P.; Usman, Muhammad A.; Sakti, Muhammad; Arifin, Jainal; Sjahril, Rizalinda; Sultan, Andi Rofian; Pertiwi, Yunialthy Dwia; Yushan, Rafael Marvin; Kusuma, Samuel Andi
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.342

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant threat in orthopaedic surgery. This study aimed to evaluate the current evidence from diagnosis to rehabilitative management of MRSA in orthopedic surgery Methods: This narrative overview synthesized current evidence across the care pathway in orthopaedics, epidemiology and pathogenesis (including key resistance/virulence determinants), diagnostic approaches (sampling strategies and rapid molecular tests), therapeutic strategies (surgery plus tailored antimicrobials and local delivery), rehabilitation considerations, prevention and stewardship programs, and emerging modalities (new antibiotics, bacteriophages, and nanotechnology-enabled delivery). Results: MRSA resistance is primarily mediated by mecA (PBP2a) and augmented by additional virulence factors (e.g., panton-valentine leukocidin). Biofilm on orthopaedic implants protects bacteria from host defences and antibiotics, underpinning recurrent infection. Diagnostic yield improves with deep tissue or implant-associated sampling, while polymerase chain reaction expedites detection of resistance genes to guide early management. Optimal treatment typically combines surgical debridement with implant retention or exchange where appropriate and prolonged, targeted antimicrobials; adjuncts include local antibiotic carriers and negative-pressure wound strategies. Innovative options—novel agents, bacteriophage therapy, and nanotechnology-based delivery—show promise in early studies. Conclusion: Integrated programs, preoperative screening/decolonization, risk-adapted prophylaxis, and antimicrobial stewardship have helped lower MRSA infection rates, yet biofilm biology and rising resistance sustain a substantial burden. Emerging options include linezolid/tedizolid or minocycline plus rifampicin, with efficacy superior to vancomycin, bacteriophage therapy as an adjunct in refractory prosthetic joint infections, and nanotechnology-enabled implant coatings to deter biofilm formation.