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All Journal Journal of Islamic Medicine The Avicenna Medical Journal International Journal of Cell and Biomedical Science Calvaria Medical Journal Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Ariany, Devy
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efektivitas Ekstrak Daun Kelor (Moringa oleifera) Terhadap Kadar Trigliserida dan Glukosa Darah Sewaktu pada Tikus Jantan Galur Sprague Dawley Diabetes Melitus Muniroh, Muniroh; Masnunah, Masnunah; Ariany, Devy
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.29672

Abstract

Background: According to data from the International Diabetes Federation (IDF), Indonesia ranks 5th in the world for the highest number of diabetes mellitus cases, with numbers predicted to continue rising. Dyslipidemia is one of the complications of diabetes mellitus, potentially leading to coronary heart disease. Kelor leaves (Moringa oleifera) contain flavonoids, which may reduce blood glucose and triglyceride levels. Objective: This study aims to evaluate the effect of Moringa oleifera leaf extract on blood glucose and triglyceride levels in male Sprague dawley rats. Methods: This experimental study involved 24 male Sprague dawley rats. Blood glucose and triglyceride levels were measured before and after administering Moringa oleifera leaf extract. The Shapiro-Wilk test assessed data normality, followed by paired t-tests, One-way ANOVA, and Pearson correlation. Results: Moringa oleifera leaf extract at a 400 mg/kg BW dose significantly reduced blood glucose levels (p=0.017). No statistically triglyceride levels decreased in all groups (p=0.195). Conclusion: Moringa oleifera leaf extract can significantly lower blood glucose levels at a dose of 400 mg/kg BW. Further research is needed to investigate the effects of Moringa oleifera on triglyceride levels
STUDI HISTOPATOLOGI PENGARUH PEMBERIAN DMBA SECARA TOPIKAL PADA ORGAN HATI MENCIT C3H/HEJ Ariany, Devy; Rahman, Abd; Rachmawati, Nurlaely Mida; Hermawati, Luluk; Irawati, Nur Bebi Ulfah
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 10 No. 1 (2025): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v10i1.1892

Abstract

Optimalisasi Waktu Fiksasi Menggunakan Formalin 10% Pada Ginjal, Hepar, dan Pankreas Tikus Sprague Dawley Untuk Pewarnaan Haematoxylin-Eosin Alwi, Muhammad Azharan; Rachmawati, Nurlaely Mida; Ariany, Devy; Hermawati, Luluk; Zulfa, Hilizza Awalina
Calvaria Medical Journal Vol 3 No 2 (2025): Edisi Desember 2025
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/kp751w77

Abstract

Background: Histotechnology is a series of procedures used to prepare histological specimens for microscopic analysis. One of the critical steps in this process is fixation, which serves to preserve tissue structure and prevent changes in shape or size. However, excessive fixation duration may lead to over-hardening of tissues, resulting in reduced quality of histological observations. Objectives: To evaluate the feasibility of two week formalin 10% fixation period on histological quality of kidney, liver, and pancreas tissues. Methods: After a 14-day adaptation period, male Sprague Dawley rats were anesthetized, necropsied, and their kidney, liver, and pancreas were fixed in 10% formalin. Histotechnical procedures included graded alcohol dehydration, toluene clearing, paraffin embedding, 6 µm sectioning, and HE staining. Preparations were observed using an Olympus BX41 microscope at magnifications of 4x–40x. Results: Two-week fixation caused structural damage to the kidney, liver, and pancreas. Damage observed included glomeruli and tubules in the kidney, the portal triad structure in the liver, and the Langerhans islet cells in the pancreas. Statistical results (if any) should be included here. Conclusions: Fixation for two weeks did not produce adequate histological preparations, and therefore, it is not recommended as a reference for developing histotechnology SOPs in related laboratories.
Preliminary Study on Long Fixation in Histological Preparations of Internal Organs of Sprague Dawley Rats Prahanarendra, Galang; Ariany, Devy; Rachmawati, Nurlaely Mida; Hermawati , Luluk; Putri, Ghea Farmaning Thias
International Journal of Cell and Biomedical Science Vol 4 No 12 (2025)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v4i12.77

Abstract

Histotechnology is a series of processes ranging from tissue handling to the preparation of slides that can be observed under a microscope. One crucial stage in this process is fixation, which serves to preserve the structure and morphology of the tissue as close as possible to its original physiological state. However, prolonged fixation duration may lead to tissue hardening, dissolution, and structural damage. This study aims to obtain supporting data for the development of a standard operating procedure (SOP) in histotechnology that can be applied in the animal house and histology laboratories of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta. The results showed that fixation for three weeks caused morphological damage to the kidney, liver, and pancreas of Sprague Dawley rats. The findings included tissue perforation in all three organs, endothelial nuclear damage in the kidney, central vein wall damage in the liver, and cellular disintegration in the pancreatic islets of Langerhans. Based on these findings, it can be concluded that a fixation duration of three weeks does not produce optimal histological images and therefore cannot be used as a reference for establishing a standard histotechnology SOP in the laboratory of the Faculty of Medicine, Syarif Hidayatullah State Islamic University Jakarta.
Aggressiveness of Indonesia Triple Negative Breast Cancer Driven by Programmed Death Ligand-1 and Tumor Microenvironment Sari, Dianidya Kumandang; Fitri Hapsari , Rr. Ayu; Ariany, Devy; Sakaraga, Deamon
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.48991

Abstract

Background: Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes in Indonesia. The expression of PD-L1 1 and TME characteristics play essential roles in both immune system avoidance and medical treatment results. The Indonesian medical field lacks a comprehensive analysis of local TNBC research data because new studies continue to emerge.  Methods: The research followed PRISMA guidelines and PECO framework for analysis. A total of 22 records were identified; 10 studies met eligibility, and 6 studies were included in the final synthesis.  Results: The studies showed a wide range of PD-L1 expression in tumor cells, from 21% to 93.5%, depending on antibody clone (SP142, SP263, 22C3) and scoring threshold. The studies showed that most tumors had high-grade characteristics between 42% and 88% while displaying high proliferative rates with Ki-67 ≥20% in more than 80% of cases. The three most common metastasis locations in patients were the lungs, bones and then the brain. The survival rates of patients improved when their CD8/CD163 and CD4/FOXP3 ratios increased. The survival outcomes of patients worsened when their PD-L1 expression levels or mRNA expression increased.  Conclusion: Indonesian TNBC shows aggressive pathological characteristics with variable PD-L1 expression and diverse tumor microenvironments. PD-L1 alone does not provide consistent prognostic value and is best interpreted together with immune-cell ratios and TIL density. Establishing standardized biomarker evaluation and adopting immune-based molecular classification could improve the precision of immunotherapy strategies in Indonesia. Keywords:Triple-negative breast cancer, PD-L1, tumor microenvironment, immune ratios, metastasis, Indonesia
Co-Authors Abd Rahman Alwi, Muhammad Azharan Fitri Hapsari , Rr. Ayu Ghea Farmaning Thias Putri Hermawati , Luluk Irawati, Nur Bebi Ulfah Luluk Hermawati Masnuna, Masnuna Muniroh, Muniroh Prahanarendra, Galang Rachmawati, Nurlaely Mida Sakaraga, Deamon Sari, Dianidya Kumandang Zulfa, Hilizza Awalina