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All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Gizi Kerja dan Produktivitas Jurnal Biosense Journal of Baja Health Science Journal of Sport Science and Tourism Activity Calvaria Medical Journal Jurnal Inovasi Pangan dan Gizi Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Zulfa, Hilizza Awalina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Efek Ekstrak Nigella sativa Terhadap Histopatologi Pankreas Dan Hepar Pada Tikus Model Diabetes Melitus Abdul Rasyid; Devy Ariany; Luluk Hermawati; Nurlaely Mida Rachmawati; Hilizza Awalina Zulfa
Jurnal Gizi Kerja dan Produktivitas Vol 6, No 1 (2025): May
Publisher : Fakultas Kedokteran Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/jgkp.v6i1.32584

Abstract

Diabetes melitus (DM) merupakan gangguan metabolik kronis yang ditandai oleh hiperglikemia akibat defisiensi absolut maupun relatif insulin, atau resistensi terhadap kerja insulin. Kondisi ini tidak hanya memengaruhi metabolisme glukosa, tetapi juga dapat menimbulkan komplikasi sistemik, termasuk kerusakan organ vital seperti hepar. Streptozotocin (STZ), suatu agen antimikroba yang diisolasi dari Streptomyces achromogenes, dikenal memiliki sitotoksisitas selektif terhadap sel β pankreas, sehingga sering digunakan untuk menginduksi model diabetes eksperimental melalui destruksi sel β. Di samping terapi farmakologis konvensional menggunakan obat antidiabetes oral (OAD), pendekatan alternatif seperti penggunaan fitoterapi telah banyak diteliti karena potensi efek terapetiknya dalam mengelola DM dan komplikasinya. Salah satu tanaman herbal yang berpotensi adalah habbatussauda (Nigella sativa) yang mampu memperbaiki kerusakan sel β pankreas serta jaringan hati. Penelitian ini bersifat eksperimental dan bertujuan mengevaluasi efek terapi habbatussauda (HS) terhadap gambaran histopatologis pankreas dan hati tikus yang diinduksi dengan STZ. Hasil menunjukkan bahwa pemberian HS dengan dosis 300 mg/kgBB/hari dapat memperbaiki struktur sel β pankreas, ditandai dengan bentuk nukleus yang lebih membulat dan susunan sel yang lebih teratur, serta menormalkan ukuran nukleus hepatosit. Kesimpulannya, habbatussauda mampu memberikan efek perbaikan pada jaringan pankreas dan hati tikus yang diinduksi STZ, berdasarkan hasil pewarnaan Hematoxylin-Eosin (HE).
EFEKTIVITAS SUPLEMEN ERGOGENIK TERHADAP PERFORMA ATLETIK : TINJAUAN PUSTAKA TERHADAP BUKTI ILMIAH TERKINI Hermawati, Luluk; Irawati, Nur Bebi Ulfah; Zulfa, Hilizza Awalina
Journal of Sport Science and Tourism Activity Vol 4, No 1 (2025): Journal of Sport Science and Tourism Activity (JOSITA)
Publisher : Fakultas Kedokteran Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/josita.v4i1.32026

Abstract

Suplemen ergogenik digunakan secara luas oleh atlet dan individu aktif untuk meningkatkan kapasitas fisik, mempercepat pemulihan pascalatihan, serta mendukung adaptasi fisiologis terhadap beban latihan yang intensif. Suplemen ini bertujuan untuk meningkatkan berbagai aspek performa seperti daya tahan, kekuatan otot, dan ketahanan terhadap kelelahan. Artikel ini bertujuan untuk meninjau bukti ilmiah terkini mengenai efektivitas berbagai jenis suplemen ergogenik yang sering digunakan, termasuk kafein, kreatin, beta-alanin, natrium bikarbonat, dan nitrat. Tinjauan pustaka dilakukan melalui pencarian artikel yang diterbitkan antara tahun 2015 hingga 2025 pada basis data PubMed, Scopus, dan Google Scholar. Hasil peninjauan menunjukkan bahwa banyak suplemen tersebut memiliki dukungan ilmiah yang kuat dalam meningkatkan performa atletik, apabila dikonsumsi dengan dosis yang tepat, waktu penggunaan yang sesuai, serta disesuaikan dengan jenis olahraga dan karakteristik fisiologis individu. Namun, efektivitasnya tidak bersifat universal dan dapat bervariasi tergantung pada berbagai faktor kontekstual. Oleh karena itu, edukasi yang berbasis bukti ilmiah serta pengawasan oleh tenaga kesehatan atau profesional olahraga sangat penting untuk memastikan keamanan penggunaan, menghindari efek samping, dan memperoleh manfaat yang optimal secara individual dan berkelanjutan.
ASI SEBAGAI INTERVENSI KESEHATAN IBU DAN ANAK Zulfa, Hilizza Awalina; Adhayati, Baety; Prameswari, Yuda Nabella; Amelia, Rossa; Irawati, Nur Bebi Ulfah; Hermawati, Luluk
JOURNAL OF BAJA HEALTH SCIENCE Vol. 5 No. 02 (2025): Journal of Baja Health Science
Publisher : Universitas Banten Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47080/gh2m9936

Abstract

Cakupan Air Susu Ibu (ASI) eksklusif selama enam bulan pertama kehidupan di Indonesia masih tertinggal, hanya mencapai sekitar 52,5% pada tahun 2022. Padahal ASI tidak hanya menyediakan energi makronutrien seperti karbohidrat, protein, dan lemak, tetapi juga mengandung mikronutrien penting termasuk vitamin dan mineral. ASI juga mendukung perkembangan organ secara optimal, membentuk kekebalan, serta mengatur metabolisme tubuh. Meskipun manfaat ASI begitu banyak, implementasi menyusui di Indonesia memiliki beragam tantangan. Artikel ini meninjau bukti ilmiah terkini mengenai peran ASI sebagai pondasi kesehatan ibu dan anak dari dua sudut pandang utama: biomedis dan kesehatan masyarakat. Pencarian literatur dilakukan melalui basis data PubMed dan Google Scholar dengan kata kunci breastfeeding, breast milk, maternal health, dan child health. Hanya artikel yang diterbitkan antara tahun 2015 dan 2025 yang dipilih berdasarkan relevansinya dengan topik dan kesesuaian metodologinya. Praktik pemberian ASI eksklusif selama enam bulan pertama terbukti efektif menurunkan angka kesakitan, kematian bayi, serta risiko stunting. Namun, cakupan ASI eksklusif di Indonesia masih belum optimal akibat berbagai hambatan seperti keterbatasan cuti melahirkan, kurangnya fasilitas laktasi di tempat kerja, serta gencarnya promosi susu formula yang menjadi penghalang bagi ibu untuk memberikan ASI. Aktivitas menyusui menjadi sebuah investasi biologis dan emosional yang berdampak positif bagi ibu dan anak. Dalam mendukung praktik menyusui yang optimal, diperlukan kebijakan dan dukungan sosial yang memadai, termasuk fasilitas laktasi dan edukasi yang menyeluruh
Bioactive proteins in breast milk and their impact on infant gut development Hermawati, Luluk; Irawati, Nur Bebi Ulfah; Zulfa, Hilizza Awalina; Fidusia, Amanah Eva; Agustianti, Erika; Husna, Firda Asma’ul
Jurnal Inovasi Pangan dan Gizi Vol. 2 No. 2: (August) 2025
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/jipagi.v2i2.2147

Abstract

Background: During early stages of life, breast milk is the mainstay of nutrition. Beyond delivering vital amino acids, certain proteins like lactoferrin, α-lactalbumin, sIgA, and lysozyme bolster the infant's gastrointestinal system and provide protective mucosal factors alongside immunomodulatory functions, helping shape the gut microbiome. The goal of this review is to analyze the scientific literature on the types and composition of proteins in breast milk, their biological functions, and their effects regarding the development and protection of the infant’s gastrointestinal tract with special focus on the mechanisms of mucosal immunity, mucosal defense, and microbial colonization. Methods: A literature search was conducted through PubMed, and Google Scholar databases with the terms bioactive, breastmilk, gut, infant, and microbiota. Only articles published between 2015 and 2025 were chosen for their relevance to the topic and methodological soundness. Findings: Whey proteins, which dominate the early lactation phase, contain bioactive peptides that are easily absorbed and support enterocyte maturation. Lactoferrin and sIgA contribute to maintaining mucosal integrity and preventing pathogen colonization. Growth factors such as epidermal growth factor (EGF) and transforming growth factor-beta (TGF-β) accelerate epithelial maturation and strengthen tight junctions, while other proteins like osteopontin and beta-casein help shape a favorable microbial ecosystem. Conclusion: Breast milk proteins contribute multifaceted roles in gastrointestinal and immune system development, underscoring the importance of exclusive breastfeeding as a foundation for neonatal gastrointestinal and immunological health. Novelty/Originality of this article: This review provides a comprehensive synthesis of the diverse roles of breast milk proteins in shaping infant gastrointestinal development and mucosal immunity by emphasizing perspectives that integrate evidence focused on nutrition, immunology, and the microbiome in a way that has not been fully addressed in previous literature.
Skrining Tekanan Darah Sebagai Langkah Preventif Komplikasi Hipertensi Pada Masyarakat Desa Kasemen, Provinsi Banten: Blood Pressure Screening as a Preventive Effort to Reduce Hypertension Complications in Kasemen Village Community, Banten Province Adhayati, Baety; Prameswari, Yuda Nabella; Hermawati, Luluk; Wulansari, Ekawati Rini; Zulfa, Hilizza Awalina; Putri, Neshya Ruriana
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 12 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i12.10337

Abstract

Hypertension is a non-communicable disease that is a leading cause of global morbidity and mortality. In Indonesia, the prevalence of hypertension continues to rise, particularly among the productive and elderly populations. This community service activity aims to conduct early detection and provide education on hypertension through blood pressure screening in Kasemen Village, Serang City, Banten Province. The method employed is a participatory approach involving faculty members and medical students from the Faculty of Medicine and Health Sciences at UNTIRTA. A total of 247 village residents participated in this activity, and from 230 valid data, it was found that 51.30% of respondents had hypertension. The highest proportion of hypertension was observed among the elderly group (71.6%) and men (80%). In addition to blood pressure measurement, education on the importance of regular blood pressure monitoring and healthy lifestyle changes was also provided to raise community awareness. The results of this activity demonstrate that community-based screening, combined with health education, is an effective strategy for preventing and controlling hypertension, while also serving as a field-based learning opportunity for medical students.
Optimalisasi Waktu Fiksasi Menggunakan Formalin 10% Pada Ginjal, Hepar, dan Pankreas Tikus Sprague Dawley Untuk Pewarnaan Haematoxylin-Eosin Alwi, Muhammad Azharan; Rachmawati, Nurlaely Mida; Ariany, Devy; Hermawati, Luluk; Zulfa, Hilizza Awalina
Calvaria Medical Journal Vol 3 No 2 (2025): Edisi Desember 2025
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/kp751w77

Abstract

Background: Histotechnology is a series of procedures used to prepare histological specimens for microscopic analysis. One of the critical steps in this process is fixation, which serves to preserve tissue structure and prevent changes in shape or size. However, excessive fixation duration may lead to over-hardening of tissues, resulting in reduced quality of histological observations. Objectives: To evaluate the feasibility of two week formalin 10% fixation period on histological quality of kidney, liver, and pancreas tissues. Methods: After a 14-day adaptation period, male Sprague Dawley rats were anesthetized, necropsied, and their kidney, liver, and pancreas were fixed in 10% formalin. Histotechnical procedures included graded alcohol dehydration, toluene clearing, paraffin embedding, 6 µm sectioning, and HE staining. Preparations were observed using an Olympus BX41 microscope at magnifications of 4x–40x. Results: Two-week fixation caused structural damage to the kidney, liver, and pancreas. Damage observed included glomeruli and tubules in the kidney, the portal triad structure in the liver, and the Langerhans islet cells in the pancreas. Statistical results (if any) should be included here. Conclusions: Fixation for two weeks did not produce adequate histological preparations, and therefore, it is not recommended as a reference for developing histotechnology SOPs in related laboratories.
CRYPTOSPORIDIOSIS: EPIDEMIOLOGI, PATOGENESIS, MANIFESTASI KLINIS, DIAGNOSIS, DAN PENATALAKSANAAN: TINJAUAN LITERATUR Irawati, Nur Bebi Ulfah; Hermawati, Luluk; Nasution, Silvia Fitrina; Damayanti, Putri; Prameswari, Yuda Nabella; Zulfa, Hilizza Awalina
JURNAL BIOSENSE Vol 9 No 2 (2026): Edisi April 2026
Publisher : Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v9i2.7673

Abstract

Cryptosporidiosis is a parasitic infection caused by protozoa of the Cryptosporidium genus that infect humans and animals worldwide. The disease remains a significant public health concern, particularly in regions with limited access to clean water and adequate sanitation. This study aimed to review recent scientific evidence regarding the epidemiology, pathogenesis, clinical manifestations, diagnosis, and management of cryptosporidiosis. A literature review method was employed by analyzing scientific articles published between 2015 and 2025 retrieved from databases including PubMed, Scopus and Google Scholar. Relevant studies were selected based on predefined inclusion criteria and analyzed narratively. The review indicates that Cryptosporidium hominis and Cryptosporidium parvum are the most common species causing human infection and account for the majority of cases worldwide. Transmission primarily occurs through the fecal–oral route via contaminated water or food, as well as direct contact with infected hosts. Infection involves parasite attachment and invasion of intestinal epithelial cells, leading to mucosal damage, malabsorption, and diarrhea. Clinical manifestations vary depending on the host's immune status, ranging from mild self-limiting diarrhea in immunocompetent individuals to severe and chronic infection in immunocompromised patients. Diagnosis is commonly established through microscopic detection of oocysts, antigen-based assays, and molecular methods such as polymerase chain reaction (PCR). Current management mainly focuses on supportive therapy, while nitazoxanide remains the only antiparasitic drug approved by the FDA for the treatment of cryptosporidiosis. Therefore, improvements in sanitation, development of diagnostic methods, and effective prevention strategies are essential to reduce the global burden of cryptosporidiosis.
HUBUNGAN KADAR GLUKOSA DARAH DENGAN KEJADIAN HIPERTENSI: STUDI CROSS-SECTIONAL DI RS SYARIF HIDAYATULLAH JAKARTA Zulfa, Hilizza Awalina; Nofisah, Nur Lailatul; Nitalia, Mery; Hermawati, Luluk
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 11 No. 1 (2026): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/asehgt73

Abstract

Hypertension is a condition characterized by an increase in systoic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg. One of the important risk factors for hypertension is elevated blood glucose levels (hyperglycemia). This study aimed to determine the association between random blood glucose levels and the occurence of hypertension at Syarif Hidayatullah Hospital, Jakarta. This study employed an observational analytic design with a cross-sectional approach. A total of 90 respondents were included using consecutive sampling, with inclusion criteria of patients aged >18 years who had complete medical records of random blood glucose and blood pressure measurements. Bivariate analysis was performed using the Chi-Square test. The result showed that 42.2% of patients with hyperglycemia had hypertension, while 31.1% had hyperglycemia without hypertension. Among patients with normal blood glucose levels, 7.8% had hypertension and 18.9% had neither hypertension nor hyperglycemia. The Chi-Square analysis demonstrated a significant association between random blood glucose levels and hypertension (p = 0.017) with an odds ratio (OR) odf 2.588, indicating that patients with hyperglycemia had appoximately 2.6 times higher risk of developing hypertension compared to normoglycemic patients. In conclusion, there is a significant association between elevated random blood glucose levels and the occurance of hypertension, suggesting that hyperglycemia is an important risk factor for hypertension.
Co-Authors Abdul Rasyid Adhayati, Baety Agustianti, Erika Alwi, Muhammad Azharan Ariany, Devy Damayanti, Putri Desy Safira Devy Ariany Ekawati Rini Wulansari Fidusia, Amanah Eva Hendry Tri Sakti Saragih Husna, Firda Asma’ul Irawati, Nur Bebi Ulfah Luluk Hermawati Nasution, Silvia Fitrina Neshya Ruriana Putri, Neshya Ruriana Nitalia, Mery Nofisah, Nur Lailatul Nurlaely Mida Rachmawati Rachmawati, Nurlaely Mida Rossa Amelia, Rossa Tianti Arum Mawarni Yuda Nabella Prameswari