Claim Missing Document
Check
Articles

Found 3 Documents
Search
Journal : Open Access DRIVERset

Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer Umaru, Isaac John; Olawale, Otitoju; Okoli, Emmanuel Chikodiri; Tensaba, Akafa Andes; Umaru, Kerenhappuch Isaac; Istifanus, Dafup Kadel; Umahi, David
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3487

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.
Microbial Isolates in Microplastic-Polluted Soil Battah, Moses Victor; Olawale, Otitoju; Abah, Moses; John, Umaru Isaac; Dauda, Maianguwa Abdulrashid; Joel, Emmanuel Askeb-nde; Vera, Caleb; Umaru, Kerenhappuch Isaac
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3705

Abstract

Microplastic pollution is a growing environmental concern, with plastic debris fragmenting into microscopic particles that contaminate soil ecosystems. Microplastics have become a major environmental concern due to their persistent presence in various ecosystems, including soil. They can act as pollutants and have detrimental effects on the environment and human health. This study aimed at isolating and identifying microbes (Bacteria and Fungi species) present in microplastic-polluted soil. Microplastic-polluted soil samples were collected from three sites (which were Kwararafa University Area Wukari to serve as the site 1, Federal Road Safety Commission Office Area Wukari to be the site 2, while Marmara Area Wukari to be the site 3), from two points; A and B and then packaged in brown envelopes which were then transferred to the Laboratory for further analysis after air-drying them for 24 hours. Then 1gram of each soil sample was weighed and suspended in 9mls of distilled water respectively; Six (6) folds of distilled water were prepared for serial dilution of each soil sample. 1ml of each sample was pour plated on NA, MAC, BA, EMB, CLED and SDA respectively. Then a smear of bacteria was prepared and allow to air dry for 30min and heat fix using flame after which was viewed under the microscope. The results obtained from this study showed that Staphylococcus spp are large, medium, small, and pinpoint in size, irregular and spherical in shape, light pink, creamy grey in color, smooth, mucoid and dried texture. Escherichia coli and Klebsiella spp here has similar morphological characteristics, both in size, shape, color, texture, margin and elevation as Staphylococcus spp. Bacillus spp and Pseudomonas spp here has similar morphological identification but differ only in their shape where Bacillus spp has a filamentous shape but Pseudomonas spp has rhizoid shape respectively. In terms of texture, Bacillus spp are Smooth, dried and mucoid but Pseudomonas spp are only smooth, dried texture. Bacillus spp and Pseudomonas spp only differ in their cell morphology where Bacillus spp appears to be rods with spores while Pseudomonas spp appears as short and long rods in pairs. They react positive to catalase, oxidase and citrate tests while negative to indole test. Aspergillus Niger and Rhizopus stolonifer were found to be the major fungi isolated from the collected sample. Aspergillus Niger and Rhizopus stolonifer are spherical in shape and are large in size. Aspergillus Niger appears powdery and Rhizopus stolonifer appears to fluffy, wood-like. In terms of color and pigmentation Aspergillus Niger species are black, black creamy on reverse while Rhizopus stolonifer appears grayish in color. The discovery of these microbes in microplastics-polluted soil offers a ray of hope for mitigating plastic pollution. By delving deeper into their capabilities and fostering collaboration between microbiologists and environment. This research will contribute to a broader understanding of the ecological impact of microplastics on soil health and functioning. By identifying microbes associated with microplastics, the specific mechanism of action employed by these bacteria in degrading microplastics can be studied subsequently.
Effect of Heavy Metals and Risk Analysis on Arable Farmlands in Selected Local Government Areas of Southern Taraba State, Nigeria Habibu, Bilyaminu; Olawale, Otitoju; Ejeh, Yakubu Ojochenemi; Umaru, Isaac John; Oko, John Odiba; Ezeonu, Chukuma Stephen; Odufa, Egbeadumah Maryanne
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 2 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i2.3819

Abstract

Heavy metals are naturally occurring metallic elements that have a relatively high density compared to water. In most of the continent including Africa, the lack of food quality usually stand to be one of the major problem in which most of the food items are laden with lots of pollutants from heavy metals. Soil is said to be the reservoir of nutrients as well as pollutants. These pollutants have been implicated in causing lots of Health issues on human and Animals. Agricultural soil plays major role in food safety, food scarcity and food security, consumption of contaminated foods has serious implication on Human and Animals health. Heavy metals are potential environmental pollutants which are toxic to the human health. When present in an Arable land, they have the ability to bio-accumulate in the soil then to crops and eventually get to humans through food consumption. This study is able to evaluate the effect of heavy metals and risk analysis of arable farmlands in some selected local government areas of southern Taraba state (Donga, Wukari and Takum). All samples were processed, and heavy metals (Pb, Cd, Cr, Hg, and As) concentration were assayed using Atomic Absorption Spectrophotometry (AAS). The results showed that Chromium had a high concentration across all the studied areas with values ranging from 1.40 mg/kg to 2.25 mg/kg. However, Cadmium followed with values ranging from 0.04 mg/kg to 0.07 mg/kg and Arsenic with values ranging from 0.03 mg/kg to 0.06 mg/kg while Lead and Mercury had the lowest concentration of less than 0.03 mg/kg across the three LGAs. Ecological Risk Assessments parameters; Target Cancer Risk, Hazard Index (HI) and Estimated Daily Intake (EDI) were determined to assess the non-carcinogenic health risk. Takum recorded the highest levels of HM having the highest health risk followed by Wukari, whereas Donga had the lowest. Consistent use of crops harvested from the sampled location may pose a serious health challenge; bio-accumulation of toxicants in the soil across the studied areas may pose a health risk due to high concentration of heavy metals which are known to generate free radicals that may lead to oxidative stress and other cellular damages in humans.