Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Journal of Psychiatry Psychology and Behavioral Research (JPPBR)
Qhabibi, Faqrizal Ria
Unknown Affiliation
Humanities Education Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
THE MAIN ROLE OF DELTA-9-TETRAHYDROCANNABINOL (THC) TO DOWNREGULATE AN EXPRESSION OF CANNABINOID 1 (CB1) RECEPTOR IN CANNABIS WITHDRAWAL SYNDROME Qhabibi, Faqrizal Ria
Journal of Psychiatry Psychology and Behavioral Research Vol. 6 No. 1 (2025): Mental Health Portrait and Intervention to Build a Safe and Strong Environment
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jppbr.2025.006.01.8

Abstract

Introduction – Cannabinoids from Cannabis sativa have derived compounds that are the best characterized like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) as the main psychogenic compounds from Cannabis sativa. In addition, THC is an important agonist for the CB1 receptors and has a responsibility to develop cannabis withdrawal. This paper aims to reveal the role of delta-9-tetrahydrocannabinol (THC) to downregulate an expression of cannabinoid 1 (CB1) receptor and their correlation to developing cannabis withdrawal syndrome. Methods – A literature review evaluating the role of delta-9-tetrahydrocannabinol (THC) to downregulate the expression of CB1 receptors. The article search strategy is using a consort statement with the main keyword “Cannabinoid 1 (CB) Receptor”, “cannabis withdrawal syndrome (CWS)”, “Delta-9-tetrahydrocannabinol (THC)” to get structured and specific results. Data extracted from Science Direct, Springer Link, PubMed, Google Scholar databases and the only papers published from 2010-2021 that are included. Results – The author reviewed 21 articles that met inclusion criteria based on the consort statement. The psychoactive effect of cannabis results from the binding of delta-9-tetrahydrocannabinol (THC) to the CB1 receptor. Discuss – Based on some experiments, intensive exposure to THC can decrease the density of CB1 receptors in the tissue by downregulating their expression. A low density of CB1 receptor will suppress the mesolimbic dopamine function that has a main role in the development of cannabis withdrawal. Conclusion – Intensive exposure to delta-9-tetrahydrocannabinol (THC) as a psychogenic substance of cannabis able to downregulate the expression of the cannabinoid 1 (CB1) receptor. The decrease of CB1 receptor density in the brain is a consequence of the downregulation of CB1 receptor expression. Based on some experiments reveal that decreasing CB1 receptor density will affect to decrease of mesolimbic dopamine function which has a main role in the development of cannabis withdrawal.
Indonesia-INTERASPIRE study: an Indonesian cross-sectional multicenter survey on cardiovascular secondary prevention in coronary heart disease Ambari, Ade Meidian; Hasan, Harris; Dwiputra, Bambang; Desandri, Dwita Rian; Hamdani, Rita; Krevani, Citra Kiki; Syaoqi, Muhammad; Ridwan, Muhammad; Anandini, Hesti; Fitra, Maha; Arso, Irsad Andi; Anggraeni, Vita Yanti; Hartopo, Anggoro Budi; Siregar, Yasmine Fitrina; Tjahjono, Cholid Tri; Tiksnadi, Badai Bhatara; Febrianora, Mega; Tarsidin, Najmi Fauzan; Arityanti, Dean; Qhabibi, Faqrizal Ria; Makes, Indira Kalyana; Susilowati, Eliana; Erwan, Nabila Erina; Hergaf, Indah Widyasari; Raynaldo, Abdul Halim
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257833

Abstract

BACKGROUND Cardiovascular disease (CVD) is projected to affect more than 23.3 million people by 2030. Therefore, CVD prevention strategies were established to decrease morbidity and mortality while enhancing overall well-being. The Joint European Societies (JES) guidelines on CVD prevention were developed to enhance preventive cardiology practices. This study aimed to evaluate the adherence to JES guidelines for cardiovascular prevention in routine clinical practice for secondary prevention. METHODS This multicenter cross-sectional study was conducted in 7 centers between August 2020 and June 2021. Patients under 80 years old who had undergone percutaneous transluminal coronary angioplasty, coronary artery bypass graft, percutaneous coronary intervention, or experienced acute coronary syndrome were identified from medical records and interviewed a year later. Descriptive statistics were used to calculate the occurrence of risk variables, medication use, and index events associated with low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c, and blood pressure (BP). RESULTS A total of 402 participants (13.9% female) were interviewed, and their medical records were reviewed. Among the study population, 74.4% had a smoking history, 35.4% had dyslipidemia, 33.1% did not meet the BP target, and only 28.4% achieved the LDL-C target. Additionally, less than half (43.8%) participated in physical activity for >150 min/week. Only 15.6% of the patients among the centers who had scored >8 for the guideline-based target score. CONCLUSIONS Most patients did not meet the guidelines for secondary prevention, primarily due to the high prevalence of dyslipidemia and physical inactivity, although some achieved the LDL-C target.
Co-Authors Ambari, Ade Meidian Anandini, Hesti Anggoro Budi Hartopo Anggraeni, Vita Yanti Arityanti, Dean Badai Bhatara Tiksnadi Cholid Tri Tjahjono Desandri, Dwita Rian Dwiputra, Bambang Erwan, Nabila Erina Febrianora, Mega Fitra, Maha Hasan, Harris Hergaf, Indah Widyasari Irsad Andi Arso, Irsad Andi Krevani, Citra Kiki Makes, Indira Kalyana Muhammad Ridwan Raynaldo, Abdul Halim Rita Hamdani Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Yasmine Fitrina Siregar