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All Journal The Indonesian Biomedical Journal Majalah Patologi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Yamin, Amalia
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade Rianti, Andi Marcha; Cangara, Muhammad Husni; Yamin, Amalia; Dahlan, Haslindah; Ilyasa, Muhammad Riza; Miskad, Upik Anderiani
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3523

Abstract

BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome. Fibroblast growth factor receptor 2 (FGFR2) overexpression is correlated with a worse prognosis in colorectal adenocarcinoma patients. Unfortunately, there are not many studies investigating the relationship between FGFR2 with histopathological grade and TILs in Indonesia. This study was conducted to analyze the correlation between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma.METHODS: Immunohistochemistry examination using FGFR2 rabbit polyclonal antibody was performed on 94 paraffin-embedded colorectal adenocarcinoma blocks and its expression was examined using a light microscope. The relationship between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma was statistically analyzed.RESULTS: Of the 94 samples examined, low grade adenocarcinoma was more common (n=76), of which 60.5% showed high FGFR2 expression. While in high grade adenocarcinoma, 83.3% of the samples showed high FGFR2 expression. In low grade TILs (n=30), 80% showed strong FGFR2 expression. While in high grade TILs (n=17), 64.7% showed weak FGFR2 expression. Based on statistical analysis, there was a significant correlation between FGFR2 expression and TILs grade (p=0.008). However, there was no significant association with histopathological grade (p=0.127).CONCLUSION: The significant correlation between FGFR2 expression and TILs grade suggests that FGFR2 may be used as a prognostic and predictive marker in colorectal adenocarcinoma.KEYWORDS: FGFR2, Colorectal adenocarcinoma, TILs, Histopathological grade
Characteristics of ER, PR, HER2 and Ki67 Expression in Invasive Breast Cancer Patients at RSUP Dr. Wahidin Sudirohusodo, Makassar 2021-2023 Rahmawani, Surya; Nelwan, Berti J; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Sungowati, Ni Ketut; Yamin, Amalia; Aslam, Muhammad; Mardiati, Mardiati
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1589

Abstract

Background: Invasive breast carcinoma is the most common type of breast cancer among women globally, with high mortality. In Indonesia, it ranks first based on Globocan 2020 data. Objective: To determine the expression of prognostic and predictive markers—Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67—in breast cancer cases at RSUP Wahidin Sudirohusodo. Methods: A descriptive study was conducted on 71 samples from 2021–2023. Data on age, histopathologic grade, and marker expression (HER2, ER, PR, Ki67) were analyzed. Samples were stained and examined microscopically. Chi-square tests were performed using SPSS version 27. Results: Among the 71 samples, 47.89% were from patients aged < 50 years and 52.11% from those >/ 50. Grade 2 was most common (59.15%). HER2 expression was negative in 59.15% of samples, ER positive in 83.10%, PR positive in 67.61%, and Ki67 expression was low in 52.11%. Conclusion: Most cases showed negative HER2 and positive ER/PR expression with low Ki67, indicating the relevance of hormonal receptors and proliferation rate as prognostic indicators. These markers are crucial for prognosis and treatment planning in breast carcinoma.
Thyroid Leiomyosarcoma: A Rare Case Report Juanita; Maulana, Aries; Yamin, Amalia; prihatni, Imeldi; Sungowati, Ni Ketut; Miskad, Upik Anderiani
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.553

Abstract

Background Primary thyroid leiomyosarcoma is a very rare tumor. The incidence is less than 0.01% of all primary thyroid tumors. Thyroid leiomyosarcoma are tumours showing smooth muscle differentiation, originating from thyroid gland vascular smooth muscle. Case Description Female, 47 years old, with lump on the left neck since 1 year ago, getting bigger in the last 3 months, no shortness of breath, no history of previous surgery. Physical examination revealed a mass was 13x6 cm in size, solid, firm.  Cytological features from fine needle aspiration biopsy (FNAB) showed cellular spindle cells with atypical, pleomorphic, hyperchromatic nuclei and  several normal thyroid follicles among them, sugesting  malignant thyroid tumor (Bethesda VI). Total thyroidectomy was performed, followed by histopathological examination. Microscopically showed proliferation of atypical, pleomorphic, hyperchromatic spindle cells with eosinophilic cytoplasm. The spindle cells arranged in fascicular and interlacing pattern. Several follicular thyroid are entrapped within this atypical spindle cells. Based on these finding, this case was diagnosed as anaplastic thyroid carcinoma. To confirm the diagnosis, immunohistochemical examination with cytokeratin, desmin and Ki-67 were performed and the result showed negative for cytokeratin, positive for desmin and Ki-67 was highly positive. Based on these results, a diagnosis of thyroid leiomyosarcoma was made. Discussion and Conclusion Differential diagnosis with other primary mesenchymal thyroid  tumors should be considered in the cases with atypical spindle cells microscopic appearance. The diagnosis of thyroid leiomyosarcoma based on cytology and histopathology is difficult to establish, therefore immunohistochemical staining is required to establish the accurate final diagnosis.
Co-Authors Aslam, Muhammad Cangara, Husni Dahlan, Haslindah Ilyasa, Muhammad Riza Juanita Mardiati Mardiati Maulana, Aries Nelwan, Berti J Ni Ketut Sungowati, Ni Ketut prihatni, Imeldi Rahmawani, Surya Rianti, Andi Marcha UPIK ANDERIANI MISKAD, UPIK ANDERIANI