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All Journal Majalah Patologi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Ophthalmologica Indonesiana
Ni Ketut Sungowati, Ni Ketut
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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GAMBARAN DERAJAT HISTOPATOLOGI PENDERITA MENINGIOMA DI MAKASSAR TAHUN 2018-2022 Mutmainnah, Mutmainnah; Kaelan, Cahyono; Tawali, Suryani; Sungowati, Ni Ketut; Cangara, Muhammad Husni; Miskad, Upik Anderiani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1165

Abstract

Meningioma merupakan suatu neoplasma dengan pertumbuhan lambat yang berasal dari sel-sel meningotelial lapisan araknoid. Meningioma dilaporkan merupakan tumor dengan insidensi tersering di Amerika Serikat, yaitu sekitar 36% dari seluruh tumor otak. Berdasarkan WHO, histopatologik meningioma terbagi dalam derajat 1 (jinak), derajat 2 (atipikal) dan 3 (ganas). Tujuan penelitian ini untuk melihat gambaran derajat histopatologi penderita meningioma di Makassar tahun 2018-2022. Penelitian kami menggunakan metode deskriptif, yang dilakukan di Makassar dari Januari 2018 hingga Desember 2022. Pada penelitian ini yang dinilai adalah usia, jenis kelamin, lokasi tumor, dan derajat histopatologi meningioma. Analisis data menggunakan software SPSS v.20. Sebanyak 200 sampel, usia 40-60 tahun paling banyak ditemukan yaitu 124 orang (62,0%), paling banyak jenis kelamin wanita yaitu 158 orang (79,0%), lokasi meningioma paling banyak berada di cerebri yaitu 83 orang (41,5%), serta meningioma derajat 1 merupakan yang terbanyak, yaitu 179 kasus (89,5%).
Characteristics of ER, PR, HER2 and Ki67 Expression in Invasive Breast Cancer Patients at RSUP Dr. Wahidin Sudirohusodo, Makassar 2021-2023 Rahmawani, Surya; Nelwan, Berti J; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Sungowati, Ni Ketut; Yamin, Amalia; Aslam, Muhammad; Mardiati, Mardiati
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1589

Abstract

Background: Invasive breast carcinoma is the most common type of breast cancer among women globally, with high mortality. In Indonesia, it ranks first based on Globocan 2020 data. Objective: To determine the expression of prognostic and predictive markers—Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67—in breast cancer cases at RSUP Wahidin Sudirohusodo. Methods: A descriptive study was conducted on 71 samples from 2021–2023. Data on age, histopathologic grade, and marker expression (HER2, ER, PR, Ki67) were analyzed. Samples were stained and examined microscopically. Chi-square tests were performed using SPSS version 27. Results: Among the 71 samples, 47.89% were from patients aged < 50 years and 52.11% from those >/ 50. Grade 2 was most common (59.15%). HER2 expression was negative in 59.15% of samples, ER positive in 83.10%, PR positive in 67.61%, and Ki67 expression was low in 52.11%. Conclusion: Most cases showed negative HER2 and positive ER/PR expression with low Ki67, indicating the relevance of hormonal receptors and proliferation rate as prognostic indicators. These markers are crucial for prognosis and treatment planning in breast carcinoma.
Thyroid Leiomyosarcoma: A Rare Case Report Juanita; Maulana, Aries; Yamin, Amalia; prihatni, Imeldi; Sungowati, Ni Ketut; Miskad, Upik Anderiani
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.553

Abstract

Background Primary thyroid leiomyosarcoma is a very rare tumor. The incidence is less than 0.01% of all primary thyroid tumors. Thyroid leiomyosarcoma are tumours showing smooth muscle differentiation, originating from thyroid gland vascular smooth muscle. Case Description Female, 47 years old, with lump on the left neck since 1 year ago, getting bigger in the last 3 months, no shortness of breath, no history of previous surgery. Physical examination revealed a mass was 13x6 cm in size, solid, firm.  Cytological features from fine needle aspiration biopsy (FNAB) showed cellular spindle cells with atypical, pleomorphic, hyperchromatic nuclei and  several normal thyroid follicles among them, sugesting  malignant thyroid tumor (Bethesda VI). Total thyroidectomy was performed, followed by histopathological examination. Microscopically showed proliferation of atypical, pleomorphic, hyperchromatic spindle cells with eosinophilic cytoplasm. The spindle cells arranged in fascicular and interlacing pattern. Several follicular thyroid are entrapped within this atypical spindle cells. Based on these finding, this case was diagnosed as anaplastic thyroid carcinoma. To confirm the diagnosis, immunohistochemical examination with cytokeratin, desmin and Ki-67 were performed and the result showed negative for cytokeratin, positive for desmin and Ki-67 was highly positive. Based on these results, a diagnosis of thyroid leiomyosarcoma was made. Discussion and Conclusion Differential diagnosis with other primary mesenchymal thyroid  tumors should be considered in the cases with atypical spindle cells microscopic appearance. The diagnosis of thyroid leiomyosarcoma based on cytology and histopathology is difficult to establish, therefore immunohistochemical staining is required to establish the accurate final diagnosis.
Diffuse Granulomatous Conjunctivitis as an Ocular Manifestation of ANCA-Negative Limited Wegener’s Granulomatosis: A Case-Based Literature Review Hartono, Cindy; Pratiwi, Andi; Sungowati, Ni Ketut; Fikri, Bahrul; Eka, Hasnah
Majalah Oftalmologi Indonesia Vol 51 No 2 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i2.101588

Abstract

Introduction: Necrotizing granulomatous vasculitis, which is commonly known as Wegener's Granulomatosis (WG), frequently affects small to medium-sized blood vessels and is associated with anti-neutrophil cytoplasmic antibodies (ANCA). Despite ocular manifestations being prevalent in the disease, initial symptoms involving the eyelid and conjunctiva are infrequent. This study reports a case of an 11-year-old girl diagnosed with localized WG in the conjunctiva, with negative ANCA-test, and biopsy strongly suggested WG.   Case Report: An 11-year-old girl presented a red membrane covering the entire ocular surface and diminished vision in the left eye seven months before admission. At presentation, hand motion in the left eye was the best corrected visual acuity. There were granuloma formations in the palpebral and bulbar conjunctival, covering the entire ocular surface in the left eye. An incisional biopsy was performed in the conjunctiva, which revealed an ulcerative mucous membrane, prominent vasculitis, and necrotizing granulomas with giant cells and massive leukocyte infiltrate consistent with WG diagnosis.   Discussion: There is a need to consider the clinical manifestations suggesting the presence of vasculitis, ANCA determination, and histopathological evidence of the compromised organ to confirm the diagnosis. Overall, 82-94% of patients with WG were ANCA positive, leaving approximately 10% who tested negative, particularly those with limited WG. Moreover, a biopsy can confirm the diagnosis, specifically in ANCA-negative cases.   Conclusion: This case illustrated the consideration for WG diagnosis in limited form and negative ANCA-test. The clinical suspicion of WG and alternative diagnostic criteria using tissue biopsy might be helpful in such cases.
Co-Authors Aslam, Muhammad Cahyono Kaelan, Cahyono Cangara, Husni Eka, Hasnah Fikri, Bahrul Hartono, Cindy Juanita Mardiati Mardiati Maulana, Aries Mutmainnah Mutmainnah Nelwan, Berti J Pratiwi, Andi prihatni, Imeldi Rahmawani, Surya Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yamin, Amalia