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All Journal The Indonesian Biomedical Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Rianti, Andi Marcha
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade Rianti, Andi Marcha; Cangara, Muhammad Husni; Yamin, Amalia; Dahlan, Haslindah; Ilyasa, Muhammad Riza; Miskad, Upik Anderiani
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3523

Abstract

BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome. Fibroblast growth factor receptor 2 (FGFR2) overexpression is correlated with a worse prognosis in colorectal adenocarcinoma patients. Unfortunately, there are not many studies investigating the relationship between FGFR2 with histopathological grade and TILs in Indonesia. This study was conducted to analyze the correlation between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma.METHODS: Immunohistochemistry examination using FGFR2 rabbit polyclonal antibody was performed on 94 paraffin-embedded colorectal adenocarcinoma blocks and its expression was examined using a light microscope. The relationship between FGFR2 expression with histopathological grade and TILs grade in colorectal adenocarcinoma was statistically analyzed.RESULTS: Of the 94 samples examined, low grade adenocarcinoma was more common (n=76), of which 60.5% showed high FGFR2 expression. While in high grade adenocarcinoma, 83.3% of the samples showed high FGFR2 expression. In low grade TILs (n=30), 80% showed strong FGFR2 expression. While in high grade TILs (n=17), 64.7% showed weak FGFR2 expression. Based on statistical analysis, there was a significant correlation between FGFR2 expression and TILs grade (p=0.008). However, there was no significant association with histopathological grade (p=0.127).CONCLUSION: The significant correlation between FGFR2 expression and TILs grade suggests that FGFR2 may be used as a prognostic and predictive marker in colorectal adenocarcinoma.KEYWORDS: FGFR2, Colorectal adenocarcinoma, TILs, Histopathological grade
The Role of Tumor Budding as a Prognostic Factor in Colorectal Adenocarcinoma Rianti, Andi Marcha; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1586

Abstract

Background: Colorectal cancer is one of the most prevalent malignancies worldwide. Tumor budding has emerged as a potential prognostic indicator in colorectal adenocarcinoma. Objective: This study aimed to analyze the relationship between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma, and to assess the potential of tumor budding as a prognostic factor. Methods: A cross-sectional study was conducted using 93 colorectal adenocarcinoma samples. The association between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis was evaluated using the Chi-square and Mann-Whitney tests. Results: Among the 93 samples, a significant difference in tumor budding scores was found between cases with and without lymphovascular invasion (p = 0.003). However, no significant association was observed between tumor budding scores and histopathological grade (p = 0.685) or lymph node metastasis (p = 0.092). Additionally, a significant correlation was found between lymphovascular invasion and lymph node metastasis (p < 0.001). Conclusion: Tumor budding may serve as an important prognostic factor in colorectal adenocarcinoma, particularly in its association with lymphovascular invasion
Co-Authors Achmad, Djumadi Cangara, Husni Dahlan, Haslindah Ilyasa, Muhammad Riza Syarifuddin Wahid Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yamin, Amalia