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All Journal Jurnal Perkotaan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Health (JoH) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JRST (Jurnal Riset Sains dan Teknologi) Indonesian Journal for Health Sciences (IJHS) Community Empowerment Journal of Fundamental and Applied Pharmaceutical Science Jurnal Farmasi Indonesia BATOBO: Jurnal Pengabdian Kepada Masyarakat
Deka Prismawan
Universitas Katolik Indonesia Atma Jaya
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antibacterial Property Evaluation of Ethanolic Extract of Plantago major L. and Its Fractions Prismawan, Deka; Michael; Gunawan, Gwyneth Yovela; Kambira, Pretty Falena Atmanda
JRST (Jurnal Riset Sains dan Teknologi) Volume 10 No. 1, March 2026: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v10i1.26388

Abstract

The escalating global health crisis of antibiotic resistance necessitates the search for novel antibacterial agents from natural sources. This study investigated the potential of Plantago major L., a plant used in traditional medicine, as a source of antibacterial compounds. It aimed to evaluate the antibacterial activity of its ethanol extract and its polarity-based fractions against Escherichia coli and Staphylococcus aureus. Dried P. major L. leaves were extracted with ethanol using maceration. The crude extract was then fractionated using a sequential liquid-liquid extraction with hexane, ethyl acetate, and n-butanol. The antibacterial activity of the extract and all fractions was tested against S. aureus (ATCC 25923) and E. coli (ATCC 25922) using the broth microdilution method to determine the Minimum Inhibitory Concentration (MIC). Results revealed distinct antibacterial profiles based on fraction polarity. The ethyl acetate fraction exhibited the strongest activity against S. aureus with an MIC of 0.104 mg/mL, indicating the presence of potent semi-polar compounds like flavonoids effective against gram-positive bacteria. Conversely, the n-butanol fraction was most effective against E. coli with an MIC of 3.3 mg/mL, suggesting the role of hydrophilic compounds such as saponins in disrupting the more complex gram-negative membrane. The crude ethanol extract showed lower activity, confirming the critical role of fractionation in concentrating the bioactive compounds. Plantago major L. possesses significant antibacterial potential, with its active compounds concentrated in specific polarity-based fractions. These findings validate its traditional use and support its further development as an alternative therapy in the face of growing antibiotic resistance.
Dampak Urbanisasi terhadap Kesehatan Mental di Perkotaan Indonesia dan Peran Intervensi Kefarmasian: Studi Literatur Prismawan, Deka; Michael, Michael
Jurnal Perkotaan Vol. 15 No. 1 (2023): Juni 2023
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/perkotaan.v15i1.5531

Abstract

Urbanisasi di Indonesia telah membawa perubahan signifikan dalam struktur sosial, ekonomi, dan lingkungan kota-kota besar, yang berdampak pada peningkatan prevalensi masalah kesehatan mental. Penelitian ini bertujuan untuk mengidentifikasi dampak urbanisasi terhadap kesehatan mental di perkotaan Indonesia dan mengevaluasi peran intervensi farmasi dalam mengatasi kondisi tersebut. Melalui metode pengulasan literatur, ditemukan bahwa faktor-faktor seperti kepadatan penduduk, lingkungan fisik yang buruk, dan ketimpangan sosial ekonomi berkontribusi terhadap meningkatnya masalah kesehatan mental seperti depresi, kecemasan, dan PTSD. Kelompok yang paling rentan adalah anak muda, wanita, dan masyarakat berpenghasilan rendah. Tantangan utama dalam layanan kesehatan mental mencakup rendahnya ketersediaan profesional kesehatan mental dan stigma sosial yang kuat. Apoteker memainkan peran kunci dalam pengelolaan terapi obat, deteksi dini, dan pendidikan pasien, serta membantu mengatasi stigma dan keterbatasan akses layanan kesehatan. Studi menunjukkan bahwa intervensi farmasi yang efektif, termasuk digitalisasi layanan kesehatan mental dan integrasi apoteker dalam tim kesehatan mental, dapat meningkatkan kualitas perawatan dan aksesibilitas layanan di perkotaan. Hasil penelitian ini diharapkan dapat memberikan perspektif akademik untuk penyesuaian kebijakan dan strategi efektif guna meningkatkan kualitas kesehatan mental di perkotaan Indonesia.
Karakterisasi Farmakognostik dan Skrining Fitokimia Daun Tabebuia rosea sebagai Bahan Baku Obat Herbal Prismawan, Deka; Michael, Michael; Natalia, Felicia
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.509

Abstract

Tabebuia rosea is a tropical plant with potential as a raw material for traditional medicine. Parts of this plant like leaves, bark, and flower, indicates potential biological activity like antiinflammation, antibacterial, antioxidant, antidiabetic, and antiproliferative. but its pharmacognostic and phytochemical characterization remains limited, especially in the leaves. This study aims to evaluate the pharmacognostic characteristics and phytochemical content of T. rosea leaves as a basis for standardization. Fresh T. rosea leaves were collected, dried, and ground into a fine powder. Evaluations included organoleptic and macroscopic analysis, microscopic examination, moisture content, total ash content, and phytochemical screening for secondary metabolites such as alkaloids, flavonoids, tannins, saponins, coumarins, triterpenoids, and phenolics. The leaves exhibited a lanceolate shape with smooth margins, pointed tips, and pinnate venation. Microscopic analysis revealed diagnostic features such as trichomes, calcium oxalate crystals, and parenchyma. The moisture content was 7.8%, and total ash content was 11.91%. Phytochemical screening confirmed the presence of flavonoids, tannins, phenolics, and alkaloids, while saponins and coumarins were not detected. This study provides fundamental data for the identification and standardization of T. rosea leaf simplisia. The presence of bioactive compounds, particularly flavonoids and alkaloids, supports its potential as a phytopharmaceutical raw material. Further research is needed to isolate and evaluate the pharmacological activities of these compounds.
Co-Authors Agustin, Julia Then Alicia Angela Tanoso Anugrah, Daru Seto Bagus Aprilia Ambarwati Caitlin Leticia Apin Clarissa Max Daru Seto Bagus Anugrah Dion Notario Diyah, Nuzul Wahyuning Eriza T. Heriwiyanti Florensia Irena Angellika Gita M. Warsito Greta Niken Gunawan, Gwyneth Yovela Kambira, Pretty Falena Atmanda Kambira, Pretty Falena Atmanda Kambira Karmill Trinanda Khrisna Pramudya Tectona Malau Ledianasari Ledianasari Leonardo, William Lily Agista Nurfazriah Liu, Auren Lusy Noviani Meirisa Meirisa Michael Michael Michael Michael Kim Putra Jaya Michael Michael Michael Michael Monika Arvia Chiara Natalia, Felicia Nicky Nathanael Patrick Renata Prasetyanto, Eko Adi Rany Windysari Robby Sutedjo Robi'atul F. Hartasari Rony, Zahara Tussoleha Shannen Ivanka Gunardi Siswandi, Alodia Jeconiah Valeska Aurelia Sulisyanto Vandy Vandy Verda, Vanessia Vivian