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All Journal Indonesian Journal of Global Health research JHN: Journal of Health and Nursing Indonesian Journal of Global Health Research
Olga Rasiyanti Siregar
Universitas Sumatera Utara
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Relationship between Age and the Occurrence of Depression Symptoms in Children with Acute Lymphoblastic Leukemia Dwika Intania Riano; Ika Citra Dewi Tanjung; Ririe Fachrina Malisie; Arlinda Sari Wahyuni; Olga Rasiyanti Siregar; Rini Savitri Daulay
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6230

Abstract

In children and adolescents, depressive symptoms often presenting as irritability, anhedonia, or behavioral changes. Despite significant advancements in survival rates due to improved therapeutic protocols, the psychological burden experienced by children with ALL.Objective: To evaluate the relationship between age and the presence of depressive symptoms in children diagnosed with ALL.Methods: A cross-sectional study was done using consecutive sampling with 40 children aged from 7 to 18 years old acquired, conducted from August to October 2024 at the outpatient unit of Adam Malik Hospital, Medan. Forty children aged 7–18 years with a confirmed diagnosis of ALL were included. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Categorical variables were analyzed using the chi-square test, followed by bivariate to identify significant predictors of depression.Results: Among the 40 participants, the most age group were children ≤ 10 years old (65%). A statistically significant association was found between age group and the presence of depressive symptoms (p = 0.001, OR= 33,3). Conclusions: Age is significantly associated with the severity and presence of depressive symptoms in pediatric patients with ALL. Older children were more likely to report higher levels of depression. Psychological evaluation and targeted mental health support may be especially important in older age groups.
Accuracy of Hemoglobin Measurement using the SD Biosensor Standard G6PD Analyzer as Point-of-Care in Pediatric Populations in Malaria-Endemic Regions Kevin Effendi; Rosmayanti Syafriani Siregar; Hendri Wijaya; Olga Rasiyanti Siregar; Arlinda Sari Wahyuni; Ayodhia Pitaloka Pasaribu
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6918

Abstract

Background: Malaria remains a significant public health concern, particularly in endemic regions, is frequently associated with anemia in children. Accurate hemoglobin measurement is crucial for diagnosing anemia, especially in resource-limited settings. This study compares the accuracy of SD Biosensor Standard G6PD Analyzer with Hemocue HB301 System for hemoglobin measurement among children in malaria-endemic areas. Objective: To determine the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), negative likelihood ratio (LR-), pretest odds, post-test odds, and overall accuracy of the SD Biosensor Standard G6PD Analyzer compared to the Hemocue HB301 System. Method: This cross-sectional diagnostic study involved 325 children aged 6-18 years in Kualuh Leidong District. Secondary data were obtained from a previous study conducted in August 2024, using a total sampling technique. Result: The mean hemoglobin level measured by SD Biosensor Standard G6PD Analyzer (14,22±2,21 mg/dL) was higher than that measured by Hemocue HB301 System (13,45±1,63 mg/dL), with significant difference (p=0,001). The prevalence of anemia detected by SD Biosensor and Hemocue was 12,3% and 11,4%, respectively. The SD Biosensor Standard G6PD Analyzer demonstrated a sensitivity of 70,27%, specificity of 95,14%, PPV of 65%, NPV of 96,14% and an overall accuracy of 92,31%. Conclusion: The SD Biosensor Standard G6PD Analyzer exhibited relatively low sensitivity but high specificity compared to Hemocue HB301 System in measuring hemoglobin levels among children in malaria-endemic areas. Further research is needed to compare both devices against the gold-standard automated hematology analyzer and to identify the factors influencing measurement accuracy. Keywords: Anemia, Hemocue HB301 System, Hemoglobin, Malaria, SD Biosensor Standard G6PD Analyzer
Comparison of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Pediatric Acute Lymphoblastic Leukemia Patients Before and After Induction Chemotherapy M. Arie Wibisono; Olga Rasiyanti Siregar; Fera Wahyuni; Juliandi Harahap; Bidasari Lubis; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.552

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in children. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple inflammatory biomarkers that may serve as prognostic and therapeutic response indicators. The aim of this research is to evaluate the differences in NLR and PLR before and after induction chemotherapy and to determine optimal cut-off values for predicting treatment response in pediatric ALL patients. An observational analytic study with a retrospective design was conducted on 48 pediatric ALL patients at Adam Malik General Hospital, Medan. Data were obtained from medical records between January 2023 and December 2024. Consecutive sampling was applied on this study. The Wilcoxon test was applied to assess differences in NLR and PLR, while ROC analysis was used to determine cut-off values, sensitivity, and specificity. Most patients were under 10 years of age (66.7%) and male (58.3%). Following induction chemotherapy, 87.5% achieved complete remission. Significant differences in NLR and PLR were observed before and after therapy (p<0,001). The optimal cut-off for NLR was 2.33 (sensitivity 45.2%, specificity 83.3%), while for PLR it was 219.98 (sensitivity 42.9%, specificity 83.3%). NLR and PLR significantly changed after induction chemotherapy in pediatric ALL patients. Despite limited sensitivity, both markers may serve as simple hematological tools for evaluating treatment response.
Pneumonia among Children with Congenital Heart Disease: Patterns by Shunt Type in A Tertiary Hospital in Indonesia Aris Bayu Retnaningsih Alisyah Maria; Putri Amelia; Fathia Meirina; Juliandi Harahap; Lily Irsa; Olga Rasiyanti Siregar
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1297

Abstract

Congenital Heart Disease (CHD) in children is frequently associated with lower respiratory tract infections, particularly pneumonia. Pneumonia risk in CHD is influenced by shunt type, defect size, nutritional status, yet local data regarding these associations remains limited. To determine the incidence of pneumonia in children with CHD and to analyze its association with shunt type and defect size. This retrospective cross-sectional study consecutively extracted demographic and clinical data—including CHD shunt type and defect size, nutritional status, and pneumonia diagnosis—from 134 echocardiography-confirmed medical records of hospitalized and outpatient pediatric CHD treated at Adam Malik General Hospital, Medan, from January 2022 to December 2024. Data associations were analyzed using Chi-square or Fisher’s exact tests, and prevalence ratios (PR) were calculated. Pneumonia occurred in 32.8% (44/134) of children with CHD. A higher proportion of pneumonia was observed in acyanotic CHD compared with cyanotic CHD (40.3% vs. 25.4%; PR 1.57; p = 0.066). Among acyanotic CHD, pneumonia was more frequent in children with large defects than in those with moderate to small defects (47.0% vs. 38.0%; PR 1.24; p = 0.511). Pneumonia is a frequent complication in children with CHD. Acyanotic CHD and larger defect size show a tendency toward increased pneumonia risk, although no statistically significant associations were identified.
Changes in Platelet and CD4 Lymphocyte Counts After Antiretroviral Therapy in HIV-Infected Children M. Alfarisyi Z; Rita Evalina; Olga Rasiyanti Siregar
JHN: Journal of Health and Nursing Vol. 4 No. 1 (2026): JHN: Journal of Health and Nursing, May 2026
Publisher : ASIAN PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58738/jhn.v4i1.1805

Abstract

Human immunodeficiency virus (HIV) infection in children causes immunological and hematological disturbances, most notably CD4+ T-lymphocyte depletion and thrombocytopenia. Antiretroviral therapy (ART) suppresses viral replication and may restore both, but pediatric data comparing these parameters remain limited. Objective. To compare platelet and CD4 lymphocyte counts before and after six months of ART in children with HIV. Methods. An observational analytic study with a retrospective cohort approach used medical records of children (aged 0–18 years) with HIV (ICD-10 B20) treated at Haji Adam Malik General Hospital, Medan, from 2020 to 2025. ART-naive children with platelet and CD4 results within seven days before ART and at month six were included by consecutive sampling. Values were compared using the Wilcoxon signed-rank test (SPSS version 26.0); p<0.05 was considered significant. Results. A total of 74 children were analyzed (56.8% male; 45.9% good nutritional status; 75.7% without opportunistic infection). The most common regimen was zidovudine + lamivudine + nevirapine (28.4%). Median CD4 count rose from 429 to 503 cells/mm³ (p=0.002), whereas median platelet count rose from 304,000 to 323,000/µL without reaching significance (p=0.116). A positive directional relationship between the two parameters was observed after therapy. Conclusion. Six months of ART significantly increased CD4 lymphocyte count but not platelet count, largely because most children had normal baseline platelets. Routine complete blood counts alongside CD4 monitoring remain useful, and platelet count may serve as a simple adjunct marker of immune response.
Co-Authors Aris Bayu Retnaningsih Alisyah Maria Arlinda Sari Wahyuni Ayodhia Pitaloka Pasaribu Bidasari Lubis Dwika Intania Riano Fathia Meirina Fera Wahyuni Hendri Wijaya Ika Citra Dewi Tanjung Juliandi Harahap Kevin Effendi Lily Irsa M. Alfarisyi Z M. Arie Wibisono Putri Amelia Rini Savitri Daulay Ririe Fachrina Malisie Rita Evalina Rosmayanti Syafriani Siregar