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All Journal Alotrop Jurnal Pendidikan dan Ilmu Kimia Jurnal Biologi Tropis
Balqis, Solina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology

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ANTIDIABETIC POTENTIAL OF SOLID LIPID NANOPARTICLES (SLNS) FROM KABAU SEED (ARCHIDENDRON BUBALINUM (JACK) I.C. NIELSEN) EXTRACT COATED WITH TRIMYRISTIN Balqis, Solina; Diah Miftahul Aini; Muhammad Arif Fadilah; Nurkayah; Mu'awiyatu Al-Laitsi; Lia Aseptin Murdini; Elva Febriyanti
ALOTROP Vol. 9 No. 1 (2025): Jurnal Pendidikan dan Ilmu Kimia
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v9i1.42075

Abstract

Type 2 diabetes mellitus is a global health problem that continues to increase. One alternative approach in managing diabetes is using natural materials with antihyperglycemic activity. This study aims to evaluate the effectiveness of solid lipid nanoparticles (SLN) containing Kabau seed extract (Archidendron bubalinum (Jack) I.C. Nielsen) coated with trimyristin in reducing blood glucose levels in hyperglycemic rats. Extraction was carried out by maceration using 96% ethanol, while SLN was synthesized by high-speed homogenization and ultrasonication methods. Particle size analysis showed an average diameter of 262.61 nm with a polydispersity index (PDI) of 0.144, indicating a homogeneous formulation. Phytochemical testing showed that Kabau seed extract contains alkaloids, flavonoids, tannins, and saponins contributing to antihyperglycemic activity. In vivo tests on Mus musculus showed that 20 % concentration of Kabau SLN reduced blood glucose levels by up to 97 mg/dL, approaching the effectiveness of metformin (104 mg/dL). Statistical analysis of ANOVA and BNT test showed significant differences between treatments. These results indicate that Kabau SLN has the potential as a candidate for phytopharmaceuticals in managing type 2 diabetes mellitus. Keywords: Diabetes mellitus; Kabau; solid lipid nanoparticles; trimyristin; flavonoids
Halophilic Bacteria as Promising Biocatalyst Producers: A Review on Enzyme Production Aini, Diah Miftahul; Balqis, Solina
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9125

Abstract

Halophilic bacteria, a group of extremophiles adapted to high-salinity environments, have emerged as valuable sources of relevant biocatalysts. This review aims to compile and analyse current knowledge on the enzymatic potential of halophilic bacteria. Using a systematic literature review as its primary methodology to collect, examine, and integrate academic findings on halophilic bacteria as promising sources of biocatalysts. This review highlights that halophilic bacteria possess remarkable physiological and biochemical adaptations that enable them to survive osmotic stress, with recent advances in genetic engineering and synthetic biology enhancing their enzyme production and functional efficiency. These findings underscore their potential as robust and efficient biocatalysts for sustainable industrial applications. In conclusion, halophilic bacteria represent valuable resources for biotechnology, particularly in extreme conditions where conventional enzymes fail. Future research should focus on in-depth genomic and proteomic analyses, metabolic engineering for optimized enzyme yields, industrial-scale feasibility studies, environmental impact assessments, and cross-disciplinary collaborations to fully harness their capabilities in real-world applications.
Co-Authors Diah Miftahul Aini Diah Miftahul Aini Elva Febriyanti Lia Aseptin Murdini Mu'awiyatu Al-Laitsi Muhammad Arif Fadilah Nurkayah