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All Journal Alotrop Jurnal Pendidikan dan Ilmu Kimia Journal of Community Service (Abdisci)
Lia Aseptin Murdini
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Chemistry Education Other

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ANTIDIABETIC POTENTIAL OF SOLID LIPID NANOPARTICLES (SLNS) FROM KABAU SEED (ARCHIDENDRON BUBALINUM (JACK) I.C. NIELSEN) EXTRACT COATED WITH TRIMYRISTIN Balqis, Solina; Diah Miftahul Aini; Muhammad Arif Fadilah; Nurkayah; Mu'awiyatu Al-Laitsi; Lia Aseptin Murdini; Elva Febriyanti
ALOTROP Vol. 9 No. 1 (2025): Jurnal Pendidikan dan Ilmu Kimia
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v9i1.42075

Abstract

Type 2 diabetes mellitus is a global health problem that continues to increase. One alternative approach in managing diabetes is using natural materials with antihyperglycemic activity. This study aims to evaluate the effectiveness of solid lipid nanoparticles (SLN) containing Kabau seed extract (Archidendron bubalinum (Jack) I.C. Nielsen) coated with trimyristin in reducing blood glucose levels in hyperglycemic rats. Extraction was carried out by maceration using 96% ethanol, while SLN was synthesized by high-speed homogenization and ultrasonication methods. Particle size analysis showed an average diameter of 262.61 nm with a polydispersity index (PDI) of 0.144, indicating a homogeneous formulation. Phytochemical testing showed that Kabau seed extract contains alkaloids, flavonoids, tannins, and saponins contributing to antihyperglycemic activity. In vivo tests on Mus musculus showed that 20 % concentration of Kabau SLN reduced blood glucose levels by up to 97 mg/dL, approaching the effectiveness of metformin (104 mg/dL). Statistical analysis of ANOVA and BNT test showed significant differences between treatments. These results indicate that Kabau SLN has the potential as a candidate for phytopharmaceuticals in managing type 2 diabetes mellitus. Keywords: Diabetes mellitus; Kabau; solid lipid nanoparticles; trimyristin; flavonoids
SOCIALIZATION ACTIVITIES ON THE USE OF ORGANIC WASTE (RICE HUSKS, CORN HUSK WASTE, AND COCONUT SHELLS) INTO ENVIRONMENTALLY FRIENDLY ORGANIC COLOR PIGMENTS IN MAKING MARKER INK AT SMP NEGERI B. SRIKATON Al-laitsi, Mu'awiyatu; Solina Balqis; Lia Aseptin Murdini
Jurnal Abdisci Vol 1 No 7 (2024): Vol 1 No 7 Tahun 2024
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/abdisci.v1i7.267

Abstract

Making marker ink from organic waste is one way to reduce the amount of waste that goes to landfills. Students will learn that organic waste can be reutilized into useful products. The process of making marker ink from organic waste involves innovation and creativity in creating solutions to environmental problems. This socialization can encourage students to think critically and find alternative solutions to everyday problems. This implementation activity involves lecturers and heads of study programs in the Bioengineering study program of the Muhammadiyah Sumatra Institute of Technology. The place and time of the activity at B. Srikaton State Junior High School, on October 14, 2024. This socialization activity consists of material delivery, discussion, making markers using organic materials, evaluation, and closing. We hope that this knowledge will encourage participants to care more about their surroundings and take small steps to reduce waste and make creative use of it.
Co-Authors Al-laitsi, Mu'awiyatu Balqis, Solina Diah Miftahul Aini Elva Febriyanti Mu'awiyatu Al-Laitsi Muhammad Arif Fadilah Nurkayah Solina Balqis